Intravenous Vitamin C attenuates hemorrhagic shock-related renal injury through the induction of SIRT1 in rats

Qi, Mengzhi; Yao, Yi; Xie, Ruiqin; Sun, Silei; Sun, Wenwu; Wang, Jinlong; Chen, Ying; Zhao, Bing; Chen, Erzhen; Mao, Enqiang

doi:10.1016/j.bbrc.2018.04.111

Cited by 16 publications

(13 citation statements)

References 34 publications

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“…34 It was demonstrated by Wicinski et al 35 that 4-week oral resveratrol treatment in rat models increased the serum levels of SIRT1and significantly reduced reactivity of resistant arteries partially independently of phosphodiesterase. An interesting study was conducted by Qi et al 36 They observed an association between the protective effect of intravenous vitamin C administration on hemorrhagic shock-related kidney injury and SIRT1 pathway. Most of th available researches regarding sirtuin1 studied its expression or serum activity, moreover majority of them are based on animal models.…”

Section: Discussionmentioning

confidence: 99%

<p>The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis</p>

Zbroch¹,

Bazyluk²,

Małyszko³

et al. 2020

CIA

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Introduction: Sirtuin1 (SIRT1) acts as an anti-aging protein due to anti-apoptotic, antioxidative and anti-inflammatory effect and is implicated in several diseases including diabetes or cardiovascular problems. SIRT1 renal overexpression indicates oxidative stress. Similarly, αKlotho was primarily exposed as anti-aging factor. It is primary produced in kidney. It's deficiency is associated with progression of chronic kidney disease and heart disorders. Purpose: The aim of the study was to assess the serum concentration of sirtuin1 and αKlotho in hemodialysis (HD) patients compared to healthy volunteers in regard to age, blood pressure control, residual kidney function (RKF), diabetes, cardiovascular disease, dialysis vintage and type of dialyzer. Patients and Methods: The serum level of SIRT1 and αKlotho was evaluated using ELISA tests in 103 HD patients, median age 67 years and in 21 volunteers. Blood pressure, RRF, echocardiography and dialysis parameters were assessed. HD group was divided according to the presence/absence of RKF. Results: The serum SIRT1 level was higher (28.4 vs 2.71ng/mL, p<0.0001) and αKlotho was lower (433.9 vs 756.6pg/mL, p<0.0001) in HD then in control group. αKlotho was lower in those without RKF (387.2 vs 486.2pg/mL, p=0.028). SIRT1 positively correlated with hemodialysis vintage. αKlotho negatively correlated with left ventricular posterior wall thickness. There was no significant relationship between SIRT1 and αKlotho level and age, blood pressure control, type of dialyzer, Kt/V and diabetes. Multivariate analysis revealed association of SIRT1 with ejection fraction (B −0.72; p=0.32). Conclusion: Elevated SIRT1 and lower αKlotho concentration are associated with impaired kidney function. The decrease in levels of αKlotho may also indicate heart hypertrophy in hemodialysis patients. The role of anti-aging proteins, particularly SIRT1 as biomarkers/ predictors of oxidative stress, inflammation and cardiovascular diseases need further examination.

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Section: Discussionmentioning

confidence: 99%

<p>The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis</p>

Zbroch¹,

Bazyluk²,

Małyszko³

et al. 2020

CIA

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“…Levels of serum creatinine, BUN, TNF-α, and IL-1β were lower in the vitamin C group when compared to a sham group. Conversely, levels of hemeoxygenase-1 (HO-1), a stress-response protein believed to play key roles in mediating protection against oxidant-mediated lung injury, were higher in kidneys treated with vitamin C. This effect appeared to occur irrespective of the vitamin C dose administered[ 89 ]. Another study of the effects of vitamin C administration (100 mg/kg) on renal function found a decrease in expression of the induced dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin protein in the tubular epithelial cells of rat kidneys.…”

Section: Vitamin C In Hemorrhagic Shockmentioning

confidence: 99%

Vitamin C in the critically ill - indications and controversies

Nabzdyk

Bittner

2018

WJCCM

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Ascorbic acid (vitamin C) elicits pleiotropic effects in the body. Among its functions, it serves as a potent anti-oxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology. Furthermore, an increasing body of evidence suggests that high-dose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential.

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“…A previous study found that VCM may increase NF-κB expression and produce the pro-inflammatory cytokines IL-1β and TNF-α, which leads to renal damage in rats (39). In a hemorrhagic shock rat model, VC (100-200 mg/kg) reduced renal injury by regulating Sirtuin1 (SIRT1) and acetyl (Ace)-NF-κB, thus reducing epithelial cell inflammation and apoptosis associated with oxidative stress (40).…”

Section: Discussionmentioning

confidence: 98%

Vitamin C reduces vancomycin-related nephrotoxicity through the inhibition of oxidative stress, apoptosis, and inflammation in mice

He¹,

Xu²,

Zheng³

et al. 2021

Ann Transl Med

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Background: Vancomycin (VCM) is an antibiotic widely used to treat a range of serious bacterial infections; however, it is associated with nephrotoxicity. Vitamin C (VC) is a classical antioxidant that can alleviate various organ injuries and inflammatory responses by reducing inflammation and oxidative stress.This study aimed to examine the effect of VC on VCM-related nephrotoxicity in mice.Methods: Mice were randomized into four groups: control, VCM (400 mg/kg/day), VCM (400 mg/kg/day) + VC (200 mg/kg/day), and VC (200 mg/kg/day) groups. Both VCM and VC were administered via intraperitoneal injection for 7 d, after which kidney and blood samples were collected and evaluated. Creatinine (Cr), blood urea nitrogen (BUN), superoxide dismutase (SOD), malondialdehyde (MDA), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and nuclear factor-κB (NF-κB) were measured.Results: In the VCM group, kidney index, renal injury score, cell apoptosis, serum Cr and BUN, and kidney Cr, BUN, MDA, IL-1β, IL-6, TNF-α, and NF-κB were higher compared to the control group (all P<0.05), while body weight and kidney SOD activity were lower (both P<0.05). By contrast, no differences were observed between the control and VC groups (VC and VCM + VC groups) for all these indicators. Conclusions:The antioxidant VC reduces VCM-related renal injury by reducing oxidative stress, cell apoptosis, and inflammation.

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Intravenous Vitamin C attenuates hemorrhagic shock-related renal injury through the induction of SIRT1 in rats

Cited by 16 publications

References 34 publications

<p>The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis</p>

<p>The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis</p>

Vitamin C in the critically ill - indications and controversies

Vitamin C reduces vancomycin-related nephrotoxicity through the inhibition of oxidative stress, apoptosis, and inflammation in mice

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