Intravenous Urography in Experimental Acute Renal Failure in the Rat

McLachlan, M. S. F.; Chick, Susan; Roberts, E. E.; Asscher, A. W.

doi:10.1097/00004424-197211000-00003

Cited by 16 publications

(11 citation statements)

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“…McIntosh et al [12] injected 45% sodium diatrizoate, 5 ml/kg, I day after injection of mercuric chloride or glycerol in rats, and noted no increase in mortality. Gamelli and Foster [13] administered 30% meglumine diatrizoate, 4 ml/kg, 15 min after induction of ischemic injury in dogs and noted no change in creatinine clearance determined immediately, and again at 72 h. McLachlan et al [14], however, noted a 5-fold increase in mortality in rats with renal failure induced by glycerol or mercuric chloride after receiving either 45% sodium diatrizoate, 8 ml/kg, or meglumine diatrizoate 7 ml/kg 3 days after induction of renal failure. These studies vary in terms of induction of injury, dose of contrast material, and interval between injury and administration of contrast material which may explain the differences in toxic effects.…”

Section: Discussionmentioning

confidence: 99%

Nephrotoxicity of Radiocontrast Media in Ischemic Renal Failure in Rabbits

Schultz

Lavelle

Swain

1982

Nephron

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Ischemic renal failure was produced in rabbits by occluding the renal arteries for 90 min. Group 1 (n = 8) received radiocontrast media at the time of occlusion, group 2 (n = 8) 24 h after occlusion, and group 3 (n = 8) 3 days after occlusion. Group 4 (n = 12) was subjected to ischemic injury alone, group 5 (n =4) served as sham-operated controls and group 6 (n = 4) did not undergo surgery but received radiocontrast media. Serum creatinine concentration in group 1 increased to a greater degree (p < 0.001) than all other groups and did not return to normal during the 8-day observation period. Creatinine concentration in groups 2, 3, 4, and 6 were comparable and significantly increased compared to sham-operated group (p < 0.05). Urinary excretion of alanine aïninopeptidase and N-acetyl-β-glucosaminidase in group 1 was significantly greater than all other groups (p < 0.05). Microscopic analysis indicated tubular necrosis was more prominent in group 1. Radiocontrast media is nephrotoxic and in the setting of ischemic injury may prevent recovery of renal function. Toxicity was dependent on the time of administration since functional impairment was not increased if dye was given 1 or 3 days after ischemic injury.

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Section: Discussionmentioning

confidence: 99%

Nephrotoxicity of Radiocontrast Media in Ischemic Renal Failure in Rabbits

Schultz

Lavelle

Swain

1982

Nephron

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“…F ry and C attell [15] find, as others have found in the rat [6,24], that little contrast medium appears to leave these diseased kidneys by their collecting systems. Noting that high rates of lymph flow have been recorded in acute renal failure in the dog [21], they suggested that contrast medium may leave by renal lymphatics, perhaps after leakage from tubular lumen.…”

Section: Discussionmentioning

confidence: 68%

“…Correlation is poor, however. Since a nephrogram occurs in polyuric and oliguric acute renal failure in the rat [6,24] and in man [5], low renal con centrations can probably not be explained in terms of urine output. If tubular secretion of diatrizoate occurs in man, the proportion excreted by this route appears to be small, even at low doses [10].…”

Section: Discussionmentioning

confidence: 99%

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Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

McLachlan¹,

Davies²,

Leach³

1974

Nephron

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Acute renal failure was induced in rats by intramuscular injection of glycerol. Concentrations of intravenous 125I-labelled sodium diatrizoate were measured in plasma, renal cortex and medulla, whole kidney and in lymph nodes draining the kidney. Whole kidney concentrations of diatrizoate, which changed little with time, were initially less than 20% of those in control animals. For 30 min after injection, while plasma levels were highest, renal concentrations in acute renal failure were highest in outer cortex. These observations provide further evidence that, though glomerular filtration continues in acute renal failure, it is much reduced. Diatrizoate was observed in renal lymph nodes from control animals and its existence there does not indicate tubular leakage. Smaller amounts were found in lymph nodes in acute renal failure, suggesting insignificant drainage of diatrizoate to renal lymphatics.

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“…The increase in mortality following the injection of contrast medium reported by McLachlan et al [1972] is also difficult to reconcile with the results of the study by Walsh et al[1970] who failed to demonstrate any nephrotoxicity following the intra-aortic injection of 12.5 ml/kg of a 76-percent solution of methylglucamine diatrizoate into rats in which acute renal failure had been induced by renal artery clamping. This dose is nearly double the dose employed by McLachlan et al [1972].…”

Section: Discussionmentioning

confidence: 80%