Excretion Urography Toxicity Studies in Experimental Acute Renal Failure

Abstract

Studies have been carried out on the toxicity of large doses of contrast medium (Hypaque 45%) given to rats with acute renal failure induced both by mercuric chloride and by glycerol. No increase in the expected mortality of the experimental models was observed following infusion of twice the maximum clinical dose of contrast medium.

Nephrotoxicity of Radiocontrast Media in Ischemic Renal Failure in Rabbits

“…Walsli et al [11] evaluated the effect an aortic injection of 12.5 ml/kg of 76% meglumine diatrizoate on ischemic acute tubular necrosis in rats given 3 days after injury and noted no deleterious effect on renal function. McIntosh et al [12] injected 45% sodium diatrizoate, 5 ml/kg, I day after injection of mercuric chloride or glycerol in rats, and noted no increase in mortality. Gamelli and Foster [13] administered 30% meglumine diatrizoate, 4 ml/kg, 15 min after induction of ischemic injury in dogs and noted no change in creatinine clearance determined immediately, and again at 72 h. McLachlan et al [14], however, noted a 5-fold increase in mortality in rats with renal failure induced by glycerol or mercuric chloride after receiving either 45% sodium diatrizoate, 8 ml/kg, or meglumine diatrizoate 7 ml/kg 3 days after induction of renal failure.…”