Intravenous Transplantation of Allograft hUC-MSC was More Effective Than Subarachnoid Transplantation of BM-MSCs in Patients with Parkinson's Syndrome and Secondary Parkinson's Syndrome

Wang, Wenting; Gu, Ping; Qiu, Fang; Zhang, Lina; Zhang, Zhongxia; Xie, Bing-Chuan; Dong, Ci; Han, Rui; Liu, Hui-Miao; Yan, Bowei

doi:10.1166/jbt.2016.1425

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this respect, the proposed decellularized scaffolds evidenced a good growth and colonization by hUC-SCs. These cells are attractive for several tissue engineering applications, as they are derived from an ethically undisputed source and may be non-invasively harvested at low cost [36,37,38,39]. Our observation is in line with data of Xu et al [40], who showed a good proliferation for hUC-SCs cultured on medium-stiffness matrices.…”

Section: Discussionsupporting

confidence: 86%

Cell-Free Demineralized Bone Matrix for Mesenchymal Stem Cells Survival and Colonization

et al. 2019

View full text Add to dashboard Cite

Decellularized bone matrix is receiving much attention as biological scaffolds and implantable biomaterials for bone tissue regeneration. Here, we evaluated the efficacy of a cell-free demineralized bone matrix on mesenchymal stem cells (MSCs) survival and differentiation in vitro. The seeding of human umbilical cord-derived MSCs (hUC-SCs) on decellularized bone matrices up to 14 days was exploited, assessing their capability of scaffold colonization and evaluating gene expression of bone markers. Light and Scanning Electron Microscopies were used. The obtained cell-free decalcified structures showed elastic moduli attributable to both topology and biochemical composition. Morphological observation evidenced an almost complete colonization of the scaffolds after 14 days of culture. Moreover, in hUC-SCs cultured on decalcified scaffolds, without the addition of any osteoinductive media, there was an upregulation of Collagen Type I (COL1) and osteonectin (ON) gene expression, especially on day 14. Modifications in the expression of genes engaged in stemness were also detected. In conclusion, the proposed decellularized bone matrix can induce the in vitro hUC-SCs differentiation and has the potential to be tested for in in vivo tissue regeneration.

show abstract

Section: Discussionsupporting

confidence: 86%

Cell-Free Demineralized Bone Matrix for Mesenchymal Stem Cells Survival and Colonization

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Three years later, in 2014, Wang et al enrolled 15 patients with PD (H&Y staging: 3 -5) into an experimental program on hUC-MSC transplantation, demonstrating a significant decreased in UPDRS within a month after the intervention [74]. In 2016, similar results were reported by a limited trial on intravenous transplantation of allograft hUC-MSCs in 5 PD cases, that led to reduced disease severity in 3 out of the 5 patients, based on UPDRS, in three months [75]. More recently, in 2020, Boika et al explored the efficacy of autologous MSC transplantation on 12 PD patients.…”

Section: Human Umbilical Cord-derived Mscsmentioning

confidence: 79%

The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment

et al. 2022

View full text Add to dashboard Cite

Parkinson's disease (PD) is the second most predominant neurodegenerative disease worldwide. It is recognized clinically by severe complications in motor function caused by progressive degeneration of dopaminergic neurons (DAn) and dopamine depletion. As the current standard of treatment is focused on alleviating symptoms through Levodopa, developing neuroprotective techniques is critical for adopting a more pathology-oriented therapeutic approach. Regenerative cell therapy has provided us with an unrivalled platform for evaluating potentially effective novel methods for treating neurodegenerative illnesses over the last two decades. Mesenchymal stem cells (MSCs) are most promising, as they can differentiate into dopaminergic neurons and produce neurotrophic substances. The precise process by which stem cells repair neuronal injury is unknown, and MSC-derived exosomes are suggested to be responsible for a significant portion of such effects. The present review discusses the application of mesenchymal stem cells and MSC-derived exosomes in PD treatment.

show abstract

Effect of matrix stiffness on the proliferation and differentiation of umbilical cord mesenchymal stem cells

Sun

Tan

et al. 2017

Differentiation

View full text Add to dashboard Cite

Intravenous Transplantation of Allograft hUC-MSC was More Effective Than Subarachnoid Transplantation of BM-MSCs in Patients with Parkinson's Syndrome and Secondary Parkinson's Syndrome

Cited by 5 publications

References 0 publications

Cell-Free Demineralized Bone Matrix for Mesenchymal Stem Cells Survival and Colonization

Cell-Free Demineralized Bone Matrix for Mesenchymal Stem Cells Survival and Colonization

The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment

Effect of matrix stiffness on the proliferation and differentiation of umbilical cord mesenchymal stem cells

Contact Info

Product

Resources

About