2021
DOI: 10.1177/21514593211063668
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Intravenous Tranexamic Acid Decreases Blood Transfusions and Blood Loss for Patients with Surgically Treated Hip Fractures

Abstract: Introduction Tranexamic acid can decrease blood loss related to surgery and trauma. The primary objective of this study is to examine if the use of a single dose of peri-operative TXA significantly decreases the rate of allogenic blood transfusions in the setting of operative care of hip fractures. Secondary objectives included examining if total blood loss was decreased by TXA in operative hip fractures as well as examining the safety of TXA by measuring the rates venous thromboembolism (VTE). Methods Retrosp… Show more

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Cited by 4 publications
(3 citation statements)
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“…Whilst Zufferey recorded an increase of vascular events, mainly asymptomatic deep vein thromboses, Tengberg stated a higher 90 days mortality rate (27.2 vs 10%) [20,21]. Further studies also underline our findings of both reduced blood loss and decreased transfusion rates and have postulated that tranexamic acid should be a standard protocol for proximal femoral fractures [18,19,30]. Our findings support that subtrochanteric fractures lead to the highest total blood loss and can also benefit from the use of tranexamic acid, as also proven by Lei and Tengberg [21,31].…”
Section: Discussionmentioning
confidence: 62%
See 1 more Smart Citation
“…Whilst Zufferey recorded an increase of vascular events, mainly asymptomatic deep vein thromboses, Tengberg stated a higher 90 days mortality rate (27.2 vs 10%) [20,21]. Further studies also underline our findings of both reduced blood loss and decreased transfusion rates and have postulated that tranexamic acid should be a standard protocol for proximal femoral fractures [18,19,30]. Our findings support that subtrochanteric fractures lead to the highest total blood loss and can also benefit from the use of tranexamic acid, as also proven by Lei and Tengberg [21,31].…”
Section: Discussionmentioning
confidence: 62%
“…Patients with hip fractures are particularly vulnerable and at risk for deep vein thrombosis so special consideration should be given to these possible complications that might restrict the use of tranexamic acid. Recent studies have been investigating the use in mono-trauma patients concentrating on femoral neck fractures [18][19][20][21].…”
Section: Purposementioning
confidence: 99%
“…TXA has been widely used to reduce bleeding and postoperative transfusion in geriatric hip fracture owing to its effectiveness and safety as a potent anti brinolytic [14][15]. On the other hand, geriatric nutritional problems including undernutrition, sarcopenia, and frailty have signi cant impacts on disability, occurrence of complications, and mortality after hip fractures [9].…”
Section: Discussionmentioning
confidence: 99%