Intravenous Lignocaine as an Anticonvulsant in Status Epilepticus and Serial Epilepsy

Cardiac arrhythmias in neonates receiving lidocaine as anticonvulsive treatment

“…Its anti-arrhythmic effect is selective and is due to accelerated repolarisation, decrease of the second phase of the transmembrane potential and potentiation of the potassium efflux [6]. Lidocaine has also been successfully used as an anticonvulsant drug in adults since 1955 [19]. The exact mode of action as an anticonvulsive drug is unknown [8].…”

Lidocaine for status epilepticus in adults

“…There were 10 retrospective studies [14][15][16][17][18][19][20][21]25,26] and 3 prospective studies [22][23][24]. Within the retrospective studies, 6 were retrospective case series [14,15,[17][18][19]25] and the remaining 4 were retrospective case reports [16,20,21,26].…”

“…All studies were based at single centers. The 3 prospective studies included in the systematic review were all prospective single arm studies with no control groups [22][23][24].…”

“…The country of origin of the manuscripts were as follows: USA [16][17][18]20,25,26], Spain [22,23,25], UK [21,24], Germany [19], India [14], and Sweden [15].…”

“…This difference may reflect different stages of brain maturation and thus responsiveness to therapy. Given this, we were curious as to the literature on adult subjects [14][15][16][17][18][19][20][21][22][23][24][25][26]. The goal of our study was to perform a systematic review of the literature to determine the effect of lidocaine on adult SE and RSE.…”