Anticonvulsant therapy for status epilepticus

Abstract

Lorazepam is better than diazepam or phenytoin alone for cessation of seizures and carries a lower risk of continuation of status epilepticus requiring a different drug or general anaesthesia. Both lorazepam and diazepam are better than placebo for the same outcomes. In the treatment of premonitory seizures, diazepam 30 mg in an intrarectal gel is better than 20 mg for cessation of seizures without a statistically significant increase in adverse effects. Universally accepted definitions of premonitory, early, established and refractory status epilepticus are required.

IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany

“…Lorazepam was the benzodiazepine of the first choice, consistent with published evidence at the initial stage of SE [15,16]. In a recent study from SENSE, a multicenter registry recruiting SE patients from eight large hospitals in three German-speaking countries, the proportion of clonazepam was higher than in our survey [17].…”

IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany

“…Lorazepam was the benzodiazepine of the first choice, consistent with published evidence at the initial stage of SE [15,16]. In a recent study from SENSE, a multicenter registry recruiting SE patients from eight large hospitals in three German-speaking countries, the proportion of clonazepam was higher than in our survey [17].…”

Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT

“…10-15 minutes). 27,30,31 Agitation was the most commonly reported AE in the levetiracetam-treated group, as reported previously. 26 There were no new or unexpected SARs with levetiracetam.…”

A common reference‐based indirect comparison meta‐analysis of intravenous valproate versus intravenous phenobarbitone for convulsive status epilepticus

“…An updated search conducted using the same strategies outlined in Prasad et al (2005) and Brigo et al (2012) yielded no new trials other than those already included in previously published systematic reviews.…”

IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany

“…Lorazepam was the benzodiazepine of the first choice, consistent with published evidence at the initial stage of SE [15,16]. In a recent study from SENSE, a multicenter registry recruiting SE patients from eight large hospitals in three German-speaking countries, the proportion of clonazepam was higher than in our survey [17].…”

Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT

“…10-15 minutes). 27,30,31 Agitation was the most commonly reported AE in the levetiracetam-treated group, as reported previously. 26 There were no new or unexpected SARs with levetiracetam.…”

A common reference‐based indirect comparison meta‐analysis of intravenous valproate versus intravenous phenobarbitone for convulsive status epilepticus

“…An updated search conducted using the same strategies outlined in Prasad et al (2005) and Brigo et al (2012) yielded no new trials other than those already included in previously published systematic reviews.…”

IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany

“…Lorazepam was the benzodiazepine of the first choice, consistent with published evidence at the initial stage of SE [15,16]. In a recent study from SENSE, a multicenter registry recruiting SE patients from eight large hospitals in three German-speaking countries, the proportion of clonazepam was higher than in our survey [17].…”

Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT

“…10-15 minutes). 27,30,31 Agitation was the most commonly reported AE in the levetiracetam-treated group, as reported previously. 26 There were no new or unexpected SARs with levetiracetam.…”

A common reference‐based indirect comparison meta‐analysis of intravenous valproate versus intravenous phenobarbitone for convulsive status epilepticus

“…An updated search conducted using the same strategies outlined in Prasad et al (2005) and Brigo et al (2012) yielded no new trials other than those already included in previously published systematic reviews.…”