Intravenous lidocaine 0.5 mg·kg-1 effectively suppresses fentanyl-induced cough

Comparison of the incidence and severity of cough induced by sufentanil and fentanyl: a prospective, randomised, double‐blind study

“…Immediately after injection, an anaesthetic registrar (SG), blinded to the drug therapy, recorded the occurrence of cough as 'yes' or 'no'. Depending upon the number of coughs observed, the cough severity was graded as mild (1-2), moderate (3)(4)(5) and severe (> 5). Induction of anaesthesia was commenced only after any coughing had subsided.…”

“…Estimation of sample size was based on a 35% reported incidence of cough following an intravenous bolus of fentanyl [3], assuming that sufentanil would cause a 40% reduction in the incidence. With a = 0.05 and b = 0.20 we needed to enrol 161 patients in each group; we recruited 170 patients to account for any dropouts.…”

A randomized study of the effects of perioperative i.v. lidocaine on hemodynamic and hormonal responses for cesarean section

“…administration of lidocaine 1.5-2 mg·kg −1 , 2 to 3 min before laryngoscopy, may blunt the increases in heart rate, systolic blood pressure (SBP), MAP, and catecholamine levels associated with intubation and extubation [11][12][13]. Others found that i.v.…”

The effect of dilution and prolonged injection time on fentanyl‐induced coughing*

“…Our study has shown that undiluted fentanyl, when administered through a peripheral venous line, provokes coughing in up to 32% of patients. Previous studies [1][2][3][4][5][6][7] have shown that the incidence of fentanyl-induced cough varies between 18% and 65%. In the study by Lin et al [1], 65% of the patients coughed following 2.5 lg.kg )1 fentanyl through a peripheral venous line within 2 s. A 46% incidence of cough has been reported with 7 lg.kg )1 fentanyl administered through a central venous catheter administered over 1 s by Bohrer et al [2].…”

“…Fentanyl is commonly administered prior to induction of anaesthesia because of its rapid onset, short duration of action, intense analgesia, cardiovascular stability, and no histamine release. However, previous studies [1][2][3][4][5][6][7] have found that a pre-induction bolus dose of fentanyl sometimes causes coughing. The incidence of fentanyl-induced cough varies between 18% and 65%.…”