Comparison of the incidence and severity of cough induced by sufentanil and fentanyl: a prospective, randomised, double‐blind study

Abstract

SummaryWe compared the incidence and severity of cough following a bolus of sufentanil with that following fentanyl in 510 patients, randomly allocated to receive sufentanil 0.3 lg.kg )1 , fentanyl 3 lg.kg )1 or 5 ml sterile water intravenously over 5 s. Coughing was graded depending on the number of coughs as mild (1-2), moderate (3-5) and severe (> 5). The incidence of coughing was higher after sufentanil (26 ⁄ 165; 15%) and fentanyl (54 ⁄ 169; 32%) than in the control group (0 ⁄ 168; p < 0.001). Sufentanil was also associated with a lesser severity (p = 0.039) of coughing compared with fentanyl. We conclude that equipotent boluses of sufentanil and fentanyl increase the incidence of cough, although the incidence and severity of coughing with sufentanil are less than those with fentanyl.

Dezocine prevents sufentanil-induced cough during general anesthesia induction: A randomized controlled trial

“…Sufentanil, a thienyl analog of fentanyl, which mainly activates the m-opioid receptor, may also induce cough during anesthetic induction [5,7]. Dezocine, a partial m-agonist and k-antagonist, has been discovered two novel molecular targets: the norepinephrine transporter and the serotonin transporter [9].…”

“…Sufentanil, a thienyl analog of fentanyl, which mainly activates the m-opioid receptor, may also induce cough during anesthetic induction [5,7]. According to the above study, the patients we selected were administered with one bolus of dezocine 0.1 mg/kg to test whether dezocine may effectively suppress sufentanil-induced cough by m-receptor antagonism.…”

“…However, the mechanism of opioid-induced cough remains poorly understood, and may be associated with opioid receptors [6]. Sufentanil, a thienyl analog of fentanyl that mainly activates the m-opioid receptor, may also induce cough during anesthesia induction [5,7], which may bring about a health-threatening condition in the patients, potentially to elevate heart rate, blood pressure, intracranial pressure, ocular pressure, or abdominal pressure [8].…”

The Effects of Preemptive Ketamine and Gabapentin on Volatile Agent Consumption, Postoperative Analgesic Requirement and Chronic Pain

“…Bunlar arasında vagus jukstakapiller (J) reseptörlerinin uyarılması, havayollarındaki C-liflerinin sitrik asit ile stimülasyonu, akciğer mast hücrelerinden histamin salınımı, vokal kordların ani kapanması, supraglottik bölgenin yumuşak doku ile kapanması, irritasyon reseptörlerinin uyarılarak bronkokonstriksiyona yol açması sayılabilir (5,13,14,19). Çalışmamızda olguları FBÖ şiddetine göre hafif (1-2 öksürük), orta (3-5 öksürük) ve şiddetli (5'ten fazla öksürük) olmak üzere üç gruba ayırdık.…”

Limited maximal flow rate of target‐controlled remifentanil infusion and induced cough

“…Remifentanil, an opioid used as an analgesic and antitussive agent, sometimes causes cough during induction of anaesthesia, as with other opioids of the fentanyl series [1][2][3][4]. The incidence of cough after intravenous administration of remifentanil varies between 25% and 34% [1][2][3].…”