Intravenous Fentanyl Increases Natural Killer Cell Cytotoxicity and Circulating CD16+ Lymphocytes in Humans

Yeager, Mark P.; Procopio, Marcia A.; DeLeo, Joyce A.; Arruda, Janice; Hildebrandt, Laurie; Howell, Alexandra L.

doi:10.1097/00000539-200201000-00018

Cited by 53 publications

(46 citation statements)

References 14 publications

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“…In addition to the hormone-mediated "indirect" modulation of cell proliferation, opioids modify T-and B-cell responses (Guan et al, 1997;Shahabi et al, 2000;Beagles et al, 2004;Roy et al, 2004), macrophage and microglial activity (Belkowski et al, 1995;Hu et al, 2000;Hu et al, 2002), chemotaxis (Szabo et al, 2002), cell migration (Patel et al, 2003), and natural killer cell cytotoxicity (Hsueh et al, 1996;Boyadjieva et al, 2001;Yeager et al, 2002) by modifying cytokine and chemokine release (Belkowski et al, 1995;Alicea et al, 1996;Kong et al, 1997;Wetzel et al, 2000b;Sacerdote, 2003), respective receptor expression (Zhang and Rogers, 2000), and chemokine receptor responsiveness (Grimm et al, 1998a;Rogers et al, 2000;Szabo et al, 2002Szabo et al, , 2003Chen et al, 2004) (for review, see McCarthy et al, 2001 and. These effects do not necessarily affect survival of the opioid-stimulated cell but may modify the course of inflammatory and infectious diseases, such as HIV infection, and thereby survival of the organism.…”

Section: B Chemokine-and Cytokine-mediated Effectsmentioning

confidence: 99%

“…However, based on the literature it appears reasonable to suggest that the release of endogenous opioids is aimed at inhibiting exaggerated inflammatory reactions (Gironi et al, 2000;Takeba et al, 2001;Philippe et al, 2003) and inflammatory pain (Cabot et al, 1997(Cabot et al, , 2001Machelska et al, 2002) whereas NK cell-mediated defense mechanisms against tumor cells or invading microorganisms are supported (Hsueh et al, 1995(Hsueh et al, , 1996Kowalski, 1997;Boyadjieva et al, 2001;Yeager et al, 2002).…”

Section: A Inhibition Of Inflammation With Endogenous Opioidsmentioning

confidence: 99%

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Opioids As Modulators of Cell Death and Survival—Unraveling Mechanisms and Revealing New Indications

2004

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Section: B Chemokine-and Cytokine-mediated Effectsmentioning

confidence: 99%

Section: A Inhibition Of Inflammation With Endogenous Opioidsmentioning

confidence: 99%

Opioids As Modulators of Cell Death and Survival—Unraveling Mechanisms and Revealing New Indications

2004

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“…Suppression was not seen with 0.1 mg morphine, also suggesting a dose-dependent effect. 28 Fentanyl administration has been associated with a transient increase in NK cell numbers, 29 a dosedependent reduction in NK cell activity, 30 or no reduction. 31 Remifentanil was not found to impair NK cell activity in healthy volunteers.…”

Section: Opioidsmentioning

confidence: 99%

“…La suppression n'a pas été observée avec une dose de 0,1 mg de morphine, suggérant un effet dose-dépendant. 28 L'administration de fentanyl a été associée à une augmentation transitoire du nombre de cellules NK, 29 une réduction dose-dépendante de l'activité des cellules NK 30 ou à une absence de réduction. 31 Le remifentanil n'a pas paru perturber l'activité des cellules NK chez des volontaires en bonne santé.…”

Section: Morphiniquesunclassified

Impact of anesthesia for cancer surgery: Continuing Professional Development

Green

Tsui

2013

Can J Anesth/J Can Anesth

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“…This difference may be secondary to the µ3 receptor, which is not bind by synthetic opioids such as fentanyl [119]. Although suppressive effects of fentanyl on NK cell have been reported in animals [120], in humans it has shown that fentanyl increases activity and number of NK cells, and CD8 + cytotoxic T-lymphocytes [121]. However, neither polymorphonuclear cells (PMNC) activity [122] nor cellular adhesion is affected [123].…”

mentioning

confidence: 99%

Anesthesia, cytokines and cancer recurrence

Kitamura¹,

Biaso²,

Ingelmo

et al. 2015

Glob Anesth Perioper Med

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Cytokines are essential mediators for the regulation of both innate and acquired immunity and hematopoiesis. They modulate immune cell signaling, activation, adhesion and functioning. They regulate the individual response to several insults such as infection, inflammation, trauma, and pain. Moreover, the balance between pro-inflammatory and anti-inflammatory cytokines is critical for the evolution of surgical complications and tumor progression.Several drugs, including anesthetic agents, influence cytokines secretion. Opioids, inhalational agents, intravenous and local anesthetics have shown different effects on immune system and cytokine expression. Therefore, anesthesia may play an important role in postoperative recovery and outcome of cancer patients.The aim of the present article is to review the main role of some important cytokines and the effect of anesthesia techniques and drugs on their secretion. Furthermore, current clinical evidence regarding the effects of anesthesia on cancer recurrence will be discussed. Cytokines and immune systemCytokines are proteins expressed in both innate and acquired immune system and are often named according to the secreting cells (i.e., lymphocytes, interleukins, etc.). They are essential mediators of the natural (non-specific, innate) immunity, which is the initial step of the inflammatory response. They also play a pivotal role during the specific immunity, which occurs after exposure to antigens, as they regulate lymphocyte and leukocyte activation, growth and differentiation, and the immune-mediated inflammation [1].The cytokines have different structures, but also common aspects, which are summarized in Table 1.The aim of the present article is to review the main role of some important cytokines and the effect of anesthesia techniques and drugs on their secretion. Cytokines receptorsThe cytokines receptors are formed by one or more transmembrane proteins: the extracellular portion binds the cytokine, whereas the cytoplasmic part starts the signal cascade. Based on the extracellular portion, they are divided in five categories. 1) Type I receptors, which have four α-helical stands and contain four cysteine residues and the amino acid motif tryptophanserine-X-tryptophan-serine (WSXWS).2) Type II receptors, structurally similar to Type I receptors, but without the sequence WSXWS. Cytokines functionProvided that the same cytokine may be produced during both innate and acquired immunity response, cytokines can be classified according to their functions: 1)Cytokines regulating the innate immunity and secreted by stimulated macrophages; 2)Cytokines regulating the acquired immunity and secreted by lymphocytes; 3)Cytokines stimulating the hematopoiesiss and secreted by bone marrow, leucocytes and other cells. Common aspects of CytokineTheir secretion is brief and limited in time Cytokine expressed during the innate immunity response Tumor necrosis factor (TNF-α, TNF-β)The TNF is responsible for the initial phase of acute inflammatory response, especially against ...

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Intravenous Fentanyl Increases Natural Killer Cell Cytotoxicity and Circulating CD16+ Lymphocytes in Humans

Cited by 53 publications

References 14 publications

Opioids As Modulators of Cell Death and Survival—Unraveling Mechanisms and Revealing New Indications

Opioids As Modulators of Cell Death and Survival—Unraveling Mechanisms and Revealing New Indications

Impact of anesthesia for cancer surgery: Continuing Professional Development

Anesthesia, cytokines and cancer recurrence

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