Intravenous epoprostenol sodium does not increase hepatic microsomal enzyme activity in rats

Carlton, Lisa D.; Schmith, Virginia D.; Brouwer, Kim L. R.

doi:10.1016/0090-6980(95)00139-5

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…Antipyrine and antipyridine derivatives in biological processes have become a topic of study in recent years [1][2][3]. The title compound is a new representative of antipyrine Schiff bases.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 4-((4-methoxy-benzylidene)-amino)-1,5-dimethyl- 2-phenylpyrazolidin-3-ol, C19H19N3O2

Li¹,

Nie²,

Wang³

2007

Zeitschrift Für Kristallographie - New Crystal Structures

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Source of material p-Methoxybenzaldehyde (0.1 mmol, 13.6 mg) and 4-aminoantipyrine (0.1 mmol, 20.3 mg) were dissolved in methanol (10 ml). The mixture was stirred for 30 min at room temperature to give a clear yellow solution. After allowing the resulting solution to stand in air for 7 d, yellow flake-shaped crystals were formed at the bottom of the vessel by slow evaporation of the solvent. The crystals were isolated by filtration, washed with methanol and dried in a vacuum desiccator using anhydrous CaCl2 (yield 54 %). Elemental analysis found: C, 58.1 %; H, 5.5 %; calculated for C18H16N4O3: C, 58.2 %; H, 5.6 %. DiscussionAntipyrine and antipyridine derivatives in biological processes have become a topic of study in recent years [1][2][3]. The title compound is a new representative of antipyrine Schiff bases. All bond lengths and angles are in agreement with those in similar antipyrine Schiff bases. The pyrazoline ring is essentially planar. The dihedral angle between pyrazoline ring and C14®C19 phenyl ring is 46.8(5)°. The N3N2C14C19 and C1N1C14C15 torsion angles are 155.7(2)°and 118.9(3)°, respectively. The O1 atom deviates from the pyrazoline mean plane by 0.109(3) Å, whereas the C4 and C5 atoms deviate from it on the opposite side by 0.581(8) Å and 0.149(7) Å, respectively. The C6N1 bond length of 1.277(3) Å conforms to the value for a double bond. Because of conjugation through the imine double bond, C6N1, the pyrazoline and C14®C19 substituted phenyl rings are approximately coplanar (mean deviation from the overall plane is 0.025(3)°), the dihedral angle between the two rings is 11.4(5)°. As expected, the molecular structure adopts a trans configuration around the C6N1 bond.Z. Kristallogr.

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Section: Discussionmentioning

confidence: 99%

Crystal structure of 4-((4-methoxy-benzylidene)-amino)-1,5-dimethyl- 2-phenylpyrazolidin-3-ol, C19H19N3O2

Li¹,

Nie²,

Wang³

2007

Zeitschrift Für Kristallographie - New Crystal Structures

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“…For the biological activity of Schiff bases, see: Billson et al (2000); Carlton et al (1995). For a related structure, see: Li et al (2006).…”

Section: Related Literaturementioning

confidence: 99%

N-(2,3-Dihydro-1,3-thiazol-2-ylidene)-4-[(2-hydroxybenzylidene)amino]benzenesulfonamide

Zhang

2009

Acta Cryst E

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The title compound, C16H13N3O3S2, was prepared by reaction of salicylaldehyde and sulfathiazole in methanol. The dihedral angle between the central benzene ring and the thiazole ring is 85.2 (2)° and that between the two benzene rings is 17.9 (2)°. An intramolecular O—H⋯N hydrogen bond generates an S(6) ring motif. In the crystal, molecules are held together by intermolecular N—H⋯N and C—H⋯O hydrogen bonds, forming a two-dimensional network parallel to the bc plane.

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“…For related literature, see: Ali et al (2002); Allen et al (1987); Carlton et al (1995); Coolen et al (1999); Cukurovali et al (2002); Greisen & Andreasen (1976); Jiang et al (2000); Liang et al (2002); Tarafder et al (2002).…”

Section: Related Literaturementioning

confidence: 99%

“…In recent years, the role of antipyrine and antipyridine derivatives in biological processes have become a topic of study (Carlton et al, 1995;Coolen et al, 1999;Jiang et al, 2000). Antipyrine is an antipyretic drug that is still being used to measure the total hepatic oxidase activity.…”

Section: S1 Commentmentioning

confidence: 99%

1,5-Dimethyl-4-[(5-methyl-2-furyl)methyleneamino]-2-phenyl-1H-pyrazol-3(2H)-one

Guo

2008

Acta Cryst E

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Intravenous epoprostenol sodium does not increase hepatic microsomal enzyme activity in rats

Cited by 6 publications

References 8 publications

Crystal structure of 4-((4-methoxy-benzylidene)-amino)-1,5-dimethyl- 2-phenylpyrazolidin-3-ol, C19H19N3O2

Crystal structure of 4-((4-methoxy-benzylidene)-amino)-1,5-dimethyl- 2-phenylpyrazolidin-3-ol, C19H19N3O2

N-(2,3-Dihydro-1,3-thiazol-2-ylidene)-4-[(2-hydroxybenzylidene)amino]benzenesulfonamide

1,5-Dimethyl-4-[(5-methyl-2-furyl)methyleneamino]-2-phenyl-1H-pyrazol-3(2H)-one

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