Intravenous dexketoprofen vs placebo for migraine attack in the emergency department: A randomized, placebo-controlled trial

Güngör, Fırat; Akyol, Kamil Can; Keşaplı, Mustafa; Çelik, Ahmet; Karaca, Adeviye; Bozdemır, Mehmet Nuri; Eken, Cenker

doi:10.1177/0333102415584604

Cited by 25 publications

(30 citation statements)

References 20 publications

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“…18,19 Thus, assuming a two-sided α = .05, we anticipated a sample size of 16 patients for each group to achieve 80% power. The Shapiro-Wilk test was used to evaluate the normality of all the parameters related to the subjects.…”

Section: Statistical Analysesmentioning

confidence: 99%

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The effectiveness of greater occipital nerve blockade in treating acute migraine-related headaches in emergency departments

et al. 2018

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Section: Statistical Analysesmentioning

confidence: 99%

“…Also, we considered a standard deviation as 2 points, in accordance with methods from previous studies. 18,19 Thus, assuming a two-sided α = .05, we anticipated a sample size of 16 patients for each group to achieve 80% power. An additional 12 patients (4 in each group) were included to account for potential protocol violations.…”

Section: Statistical Analysesmentioning

confidence: 99%

The effectiveness of greater occipital nerve blockade in treating acute migraine-related headaches in emergency departments

et al. 2018

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“… 4 , 10 Ibuprofen is established as effective treatment option for acute migraine according to American Academy of Neurology (AAN) and American Headache Society (AHS) Guidelines 11 , and proved to be better than placebo. 12 , 13 In a recent Cochrane review, NNT for 2-hour pain relief was 7.2 with 400 mg, and 9.7 with 200 mg ibuprofen. 12 The strength of evidence for metoclopramide and ibuprofen for the treatment of acute migraine attack is high (Level B and Level A, respectively) according to AHS guidelines.…”

Section: Introductionmentioning

confidence: 99%

Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?

Karacabey¹,

Sanri²,

Yalçınlı³

et al. 2018

Pak J Med Sci

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Objective:The aim of this study was head-to-head comparison of the efficacy and rate of adverse events of metoclopramide, ibuprofen and dexketoprofen for the acute treatment of migraine attack in the real-life conditions of a busy emergency department (ED).Methods:This was a prospective, observational, cross-sectional study. All patients who presented to the ED with a headache fulfilling the inclusion criteria were enrolled. All patients were treated by the attending emergency physicians in their daily routine. If an IV treatment in the ED was found indicated by the EP, they selected one of the options in the written departmental migraine treatment protocol.Results:During the study period, 54 patients met the inclusion criteria. The median change in the pain score was significantly different among treatment options (p<0.0001). The median pain score change at the end of the 30 minutes for treatment groups were 7.5 mm (IQR: 7.0-8.0), 5.0 mm (IQR: 4.75-7.0), and 7.0 mm (IQR: 6.0-7.25), respectively (p=0.0002). All three groups were found to be significantly different from each other in the post-hoc analysis.Conclusion:All drugs compared in this study are effective in the relief of migraine headache. However, IV dexketoprofen seems to be faster and more effective than metoclopramide and ibuprofen.

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“…Intravenous dexketoprofen is a continuously feasible treatment to diminish torment in the ED treatment of cerebral pain patients. Patients who are incredible at diminishing migraine torment are given a 50 mg partition (22.3% vs. 55.4%)[3].…”

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confidence: 99%

Efficacy of Different Drugs for Migraine Treatment

Aziz¹

2020

Biochem Pharmacol

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Migraine is a severe headache pain causing disease that is winning in excess of 4 million individuals. There causes are not surely known, yet sufferers for the most part have various sensations towards headache torment. There is no appropriate treatment for this; patients are encouraged to avoid potential risk. Different compelling medications that have demonstrated astounding outcomes in the counteractive action of headache and are mainstream today. These medications incorporate, Dexketoprofen, galcanenzuma, Erenumab, TV-48125 and Gapant (ubrozepant and rimazapant) and losmiditan (a deton). These meds have demonstrated incredible outcomes in moderating headache torment and diminishing agony days. What's more, these prescriptions can possibly treat a headache understanding with serious torment.

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Intravenous dexketoprofen vs placebo for migraine attack in the emergency department: A randomized, placebo-controlled trial

Abstract: Intravenous dexketoprofen is superior to placebo in relieving migraine headaches in the ED. It may be a suitable therapy with minimum side effects in patients presenting with a migraine headache to the ED.

Cited by 25 publications

References 20 publications

The effectiveness of greater occipital nerve blockade in treating acute migraine-related headaches in emergency departments

The effectiveness of greater occipital nerve blockade in treating acute migraine-related headaches in emergency departments

Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?

Efficacy of Different Drugs for Migraine Treatment

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