Abstract:Objective:The aim of this study was head-to-head comparison of the efficacy and rate of adverse events of metoclopramide, ibuprofen and dexketoprofen for the acute treatment of migraine attack in the real-life conditions of a busy emergency department (ED).Methods:This was a prospective, observational, cross-sectional study. All patients who presented to the ED with a headache fulfilling the inclusion criteria were enrolled. All patients were treated by the attending emergency physicians in their daily routine… Show more
“…e mixture of acetonitrilewater (v/v) was used as the mobile phase. e content of acetonitrile (POCH, Gliwice, Poland) varied in 5% increments from 50% to 80% [6]. All experiments were performed at the room temperature, 21 ± 1 (°C).…”
Section: E Chromatographic Procedurementioning
confidence: 99%
“…ey are also applied topically in the treatment of traumatic, overload, or inflammatory changes in periarticular tissues and muscles as well as for the treatment of inflammations in the oropharyngeal cavity or the dental pain. Due to the analgesic activity, the investigated drugs are used in the treatment of muscular pains, after tooth extraction, after surgery, in neuralgia, in root syndromes, in discopathy, and also in migraine [5][6][7].…”
The lipophilicity is an important parameter that influences the activity of the drugs in the human body. The reversed phase high performance thin layer chromatography was applied to determine the Log P values of ibuprofen, ketoprofen, naproxen, and flurbiprofen. The stationary phase used in the study was silica-gel coated plates. The mobile phase was the mixture of acetonitrile and water in different proportions. The content of acetonitrile varied in 5% increments from 50% to 80%. The Rm0 values were determined for the compounds with a known Log P and for the analyzed substances (ibuprofen, naproxen, ketoprofen, and flurbiprofen). The Log P values were calculated for the analyzed compounds using the regression curve Rm0 = f(Log P) parameters for the compounds with the known lipophilicity. Flurbiprofen is characterized by the highest Log P value: 3.82. The lowest one is noted for ketoprofen: 2.66. The determined Log P values of tested compounds were similar to the values calculated by the software.
“…e mixture of acetonitrilewater (v/v) was used as the mobile phase. e content of acetonitrile (POCH, Gliwice, Poland) varied in 5% increments from 50% to 80% [6]. All experiments were performed at the room temperature, 21 ± 1 (°C).…”
Section: E Chromatographic Procedurementioning
confidence: 99%
“…ey are also applied topically in the treatment of traumatic, overload, or inflammatory changes in periarticular tissues and muscles as well as for the treatment of inflammations in the oropharyngeal cavity or the dental pain. Due to the analgesic activity, the investigated drugs are used in the treatment of muscular pains, after tooth extraction, after surgery, in neuralgia, in root syndromes, in discopathy, and also in migraine [5][6][7].…”
The lipophilicity is an important parameter that influences the activity of the drugs in the human body. The reversed phase high performance thin layer chromatography was applied to determine the Log P values of ibuprofen, ketoprofen, naproxen, and flurbiprofen. The stationary phase used in the study was silica-gel coated plates. The mobile phase was the mixture of acetonitrile and water in different proportions. The content of acetonitrile varied in 5% increments from 50% to 80%. The Rm0 values were determined for the compounds with a known Log P and for the analyzed substances (ibuprofen, naproxen, ketoprofen, and flurbiprofen). The Log P values were calculated for the analyzed compounds using the regression curve Rm0 = f(Log P) parameters for the compounds with the known lipophilicity. Flurbiprofen is characterized by the highest Log P value: 3.82. The lowest one is noted for ketoprofen: 2.66. The determined Log P values of tested compounds were similar to the values calculated by the software.
“…After deleting duplicates and eliminating the papers that did not satisfy the eligibility criteria or presented one or more of the exclusion criteria, only 24 out of the 243 selected papers resulted in being eligible for further evaluation (13–36) (Figure 1, flow diagram). Figure 1.Data collection flow diagram.…”
Background The International Headache Society (IHS) has published four editions of Guidelines for acute clinical trials in migraine in the past 28 years. This continuous update process has been driven by the increasing amount of scientific data in the field of migraine and by the need to continuously improve the quality of trials. Objectives To illustrate: i) the results of the analysis on the adherence of published trials to the 3rd edition published in 2012, in order to identify the critical areas that needed to be addressed in the 4th edition and ii) the changes introduced in this latter edition for improving adherence and methodology robustness. Methods We searched and reviewed all controlled trials on acute treatment of migraine published in the period 2012–2018 and we assessed their adherence to the 3rd edition of the IHS Guidelines using a score system based on the most important recommendations. Afterwards, we compared the two editions of the Guidelines and assessed the changes between them. Results We included data from 24 controlled clinical trials. Most trials had a randomized double-blind controlled (RDB) design, while a minority (16.7%) were non-randomized double-blind trials. Less than half (44.6%) of the RDB trials used the recommended “pain-free at 2 hours” endpoint as the primary efficacy measure. Trial design and evaluation of results were the areas that diverged the most from the recommendations. Conclusion Adherence to IHS guidelines for clinical trials has been suboptimal so far. The new edition has been adapted and optimized to facilitate uptake and strengthen the quality of evidence.
“…They are applied topically in the treatment of traumatic, overstress, or inflammatory changes in periarticular tissues and muscles as well as for the treatment of inflammations in the oropharyngeal cavity or the dental pain. Due to the analgesic activity, the investigated drugs are used in the treatment of muscular pains, after tooth extraction, after surgery, inneuralgia….in neuralgina, in root syndromes, in discopathy, and also in migraine [13][14][15]. In 2013, ibuprofen was the second best-selling molecule in France.…”
A comparative theoretical study of some physicochemical properties of R and S enantiomers of ibuprofen, ketoprofen and flurbiprofen is undertaken in order to understand their reactivity. To do this, DFT and TD-DFT methods at the B3LYP/6-311G(d,p) level theory are used. The partition coefficient determined is 3.72 for ibuprofen, 2.81 for ketoprofen and 4.12. for flurbiprofen. That means that these NSAIDs are characterized by a high lipophilicity. The calculated Gibbs energies show that the R enantiomer is the most stable in the case of ibuprofen and the S enantiomer in the case of ketoprofen and flurbiprofen. The study of acidity shows that S enantiomer of ibuprofen and R enantiomers of ketoprofen and flurbiprofen are the most acidic enantiomers. TD-DFT calculations show that, the absorption maxima (λmax) of ibuprofen and flurbiprofen correspond to the HOMO→LUMO transition. For ketoprofen, these are associated with the transition HOMO→LUMO+1. These results elucidate the reactivity of the investigated NSAIDs and could help to establish a classification their efficacy.
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