Intravenous cidofovir for diffuse genital warts in the setting of multifactorial immunosuppression

Blaizot, Romain; Dutkiewicz, A.-S.; Guillet, S.; Pham‐Ledard, Anne; Beylot‐Barry, M.

doi:10.1111/jdv.13880

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Twenty‐three of these skin infections were due to bacteria, including one case of cutaneous granular bacteriosis occurring in a context of S. aureus septicaemia . Viruses were involved in four patients: one with hemithoracic zoster, one with diffuse genital warts (documented as human papillomavirus type 45, treated efficiently with cidofovir infusions) and one with diffuse herpes simplex virus (HSV) cutaneous infection. One case of HSV viraemia without cutaneous lesions was also observed.…”

Section: Resultsmentioning

confidence: 99%

Infectious events and associated risk factors in mycosis fungoides/Sézary syndrome: a retrospective cohort study

et al. 2018

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Opportunistic germs were rarely recorded, but their incidence was probably prevented by adequate prophylaxis (ongoing in 28% of patients). As in patients living with AIDS, pneumonias were frequent. On the other hand, bacterial cutaneous infections represent a specific pattern in patients with MF/SS. Patients with chronic organ failure, lymphocytopenia and SS should be considered as being at high risk for infectious events. Pneumococcal vaccination should be systematically recommended, and prophylaxis with co-trimoxazole and valaciclovir when the CD4 count is < 0·2 × 10 cells L .

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Section: Resultsmentioning

confidence: 99%

Infectious events and associated risk factors in mycosis fungoides/Sézary syndrome: a retrospective cohort study

et al. 2018

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“…Antiviral therapy with topical, intralesional, or intravenous cidofovir may be considered for immunocompromised patients with severe, refractory lesions 14. Cidofovir is an acyclic nucleoside phosphonate that competitively inhibits viral DNA polymerase, thereby preventing viral replication 79,91. Adverse effects of topical or intralesional cidofovir include irritation, erosion, post-inflammatory pigmentary changes, and superficial scars at the site of application 88.…”

Section: Managementmentioning

confidence: 99%

“…Adverse effects of topical or intralesional cidofovir include irritation, erosion, post-inflammatory pigmentary changes, and superficial scars at the site of application 88. The main adverse effect of intravenous cidofovir is nephrotoxicity, which can be prevented by saline hydration and probenecid 91…”

Section: Managementmentioning

confidence: 99%

Penile warts: an update on their evaluation and management

Leung¹,

Barankin²,

Leong³

et al. 2018

DIC

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BackgroundPenile warts are the most common sexually transmitted disease in males. Clinicians should be familiar with the proper evaluation and management of this common condition.ObjectiveTo provide an update on the current understanding, evaluation, and management of penile warts.MethodsA PubMed search was completed in Clinical Queries using the key terms ‘penile warts’ and ‘genital warts’. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews.ResultsPenile warts are caused by human papillomavirus (HPV), notably HPV-6 and HPV-11. Penile warts typically present as asymptomatic papules or plaques. Lesions may be filiform, exophytic, papillomatous, verrucous, hyperkeratotic, cerebriform, fungating, or cauliflower-like. Approximately one-third of penile warts regress without treatment and the average duration prior to resolution is approximately 9 months. Active treatment is preferable to watchful observation to speed up clearance of the lesions and to assuage fears of transmission and autoinoculation. Patient-administered therapies include podofilox (0.5%) solution or gel, imiquimod 3.75 or 5% cream, and sinecatechins (polypheron E) 15% ointment. Clinician-administered therapies include podophyllin, cryotherapy, bichloroacetic or trichloroacetic acid, oral cimetidine, surgical excision, electrocautery, and carbon dioxide laser therapy. Patients who do not respond to first-line treatments may respond to other therapies or a combination of treatment modalities. Second-line therapies include topical/intralesional/intravenous cidofovir, topical 5-fluorouracil, and topical ingenol mebutate.ConclusionNo single treatment has been shown to be consistently superior to other treatment modalities. The choice of the treatment method should depend on the physician’s comfort level with the various treatment options, the patient’s preference and tolerability of treatment, and the number and severity of lesions. The comparative efficacy, ease of administration, adverse effects, cost, and availability of the treatment modality should also be taken into consideration.

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“…Cidofovir intravenous (IV) is also an important therapeutic option in the treatment of severe or recurrent HPV infections, particularly in immunosuppressed patients [15].…”

Section: On the Therapeutical Levelmentioning

confidence: 99%

Anogenital Condyloma: Epidemiological, Clinical, Therapeutic and Evolutionary Aspects of 74 Cases in Benin

Akpadjan¹,

Attinsounon²,

Adégbidi³

et al. 2017

JCDSA

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The aim of this study was to study the epidemiological, clinical, therapeutic and evolutionary aspects of anogenital warts in Benin. A retrospective cohort study was conducted over a 4-year period from January 1 st , 2013 to December 31 st , 2016 at the Dermatology-Venerology Clinic of Cotonou. A total of 74 patients, including 67 men and middle aged 35.1 ± 10.3 years, were received for anogenital condyloma during the study period, accounting for 2.1% of the total and 28.2% of patients were received for sexually transmitted infection. The most common clinical form was acuminated condyloma (61 cases; 82.4%). HIV serology was positive in 12 patients (16.2%). Therapeutically, the use of electrocoagulation was systematic in 80% of cases. The evolvement is noticeable when 37% of the cases were recidivated and the rate of loss of sight after the first consultation was 60.8%. Early diagnosis and improvement of the technical platform will help to improve the quality of care for these patients.

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Intravenous cidofovir for diffuse genital warts in the setting of multifactorial immunosuppression

Cited by 3 publications

References 10 publications

Infectious events and associated risk factors in mycosis fungoides/Sézary syndrome: a retrospective cohort study

Infectious events and associated risk factors in mycosis fungoides/Sézary syndrome: a retrospective cohort study

Penile warts: an update on their evaluation and management

Anogenital Condyloma: Epidemiological, Clinical, Therapeutic and Evolutionary Aspects of 74 Cases in Benin

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