Intravenous and intratracheal administration of trimetoquinol, a fast-acting short-lived bronchodilator in horses with ‘heaves’

Camargo, Fernanda Carolina; Robinson, N. E.; Berney, C.; Eberhart, Susan W.; Baker, Sarah E.; Detolve, P.; Derksen, F. J.; Harkins, J. D.; Lehner, Andreas F.; Tobin, Thomas

doi:10.2746/042516406x153355

Cited by 5 publications

(22 citation statements)

References 13 publications

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“…In previous work we demonstrated that Trimetoquinol is an exceptionally potent and rapidly acting cardiac stimulant and bronchodilator, although its actions on these systems are short‐lived (Camargo et al. , 2006).…”

Section: Discussionmentioning

confidence: 99%

“…, 2006) with the goal of relating pharmacological effects to plasma TMQ concentration, the IV administration of TMQ was associated with an extremely rapid increase in HR, peaking at 160 bpm at 1 min post‐administration (Fig. 7, Camargo et al. , 2006).…”

Section: Discussionmentioning

confidence: 99%

“…In the respiratory system, this dose of TMQ produced an essentially immediate and highly significant bronchodilation (measured as a significant decrease in ΔPplmax, or maximal change in pleural pressure), which had returned to pretreatment values by 30 min post‐administration. However, an unexpected secondary phase of bronchodilation was seen, commencing at later than 1 h post‐administration, and remaining statistically significant for the remainder of the six‐hour experimental period (Camargo et al. , 2006).…”

Section: Discussionmentioning

confidence: 99%

“…The TMQ dose used for each route of administration was selected based on the pharmacodynamic responses to TMQ in the horse, which have been reported previously (Camargo et al. , 2006).…”

Section: Methodsmentioning

confidence: 99%

“…More recently, we reported the bronchodilator effects of TMQ following its intravenous (IV), intra‐tracheal (IT), oral (PO) and aerosolized (AER) administrations (Camargo et al. , 2006, 2007) to horses with heaves.…”

Section: Introductionmentioning

confidence: 99%

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Plasma and urinary concentrations of trimetoquinol by LC‐MS‐MS following intravenous and intra‐tracheal administration to horses with heaves

Camargo¹,

Robinson²,

Dirikolu

et al. 2008

Vet Pharm & Therapeutics

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Trimetoquinol (TMQ) is a very potent and fast acting bronchodilator in horses with heaves. This study assessed the plasma and urinary concentrations of TMQ in horses with heaves following administration via the intravenous (IV, 0.2 microg/kg) and intra-tracheal (IT, 2 microg/kg) routes. TMQ was administered to six horses affected with heaves (RAO - Recurrent Airway Obstruction, used interchangeably) by the above routes and plasma and urine samples collected and stored at -20 degrees C until analyzed. Solid Phase Extraction (SPE) of TMQ was followed by highly sensitive ESI(+)-LC-MS-MS (ElectroSpray Ionization, positive mode - Liquid Chromatography - Mass Spectrometry - Mass Spectrometry); with a Limit of Detection (LOD) estimated at 1 pg/mL. Following IV administration, TMQ plasma levels peaked at 1 min at 707 pg/mL, and at 9 min at 306 pg/mL following IT administration. Our results show that TMQ plasma concentrations decline rapidly following IV administration, which is consistent with the fast onset and short duration of TMQ effect that was observed in our previous studies. On the other hand, IT administration showed a very unique plasma concentration pattern. From a regulatory standpoint, the current available TMQ ELISA kit was also used in an attempt to detect TMQ from the plasma and urine samples. We report that the ELISA kit was unable to detect TMQ from any of the samples generated in these studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The TMQ dose used for each route of administration was selected based on the pharmacodynamic responses to TMQ in the horse, which have been reported previously (Camargo et al. , 2006).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasma and urinary concentrations of trimetoquinol by LC‐MS‐MS following intravenous and intra‐tracheal administration to horses with heaves

Camargo¹,

Robinson²,

Dirikolu

et al. 2008

Vet Pharm & Therapeutics

Self Cite

View full text Add to dashboard Cite

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Novel drug delivery systems and disease models for pulmonary fibrosis

Jia

Kong

et al. 2022

Journal of Controlled Release

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Catecholamine Derivatives: Natural Occurrence, Structural Diversity, and Biological Activity

Tang,

Zhao,

Tao

et al. 2023

J. Nat. Prod.

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Catecholamines (CAs) are aromatic amines containing a 3,4-dihydroxyphenyl nucleus and an amine side chain. Representative CAs included the endogenous neurotransmitters epinephrine, norepinephrine, and dopamine. CAs and their derivatives are good resources for the development of sympathomimetic or central nervous system drugs, while they also provide ligands important for G-protein coupled receptor (GPCR) research. CAs are of broad interest in the fields of chemical, biological, medical, and material sciences due to their high adhesive capacities, chemical reactivities, metal-chelating abilities, redox activities, excellent biocompatibilities, and ease of degradability. Herein, we summarize CAs derivatives isolated and identified from microorganisms, plants, insects, and marine invertebrates in recent decades, alongside their wide range of reported biological activities. The aim of this review is to provide an overview of the structural and biological diversities of CAs, the regularity of their natural occurrences, and insights toward future research and development pertinent to this important class of naturally occurring compounds.

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Intravenous and intratracheal administration of trimetoquinol, a fast-acting short-lived bronchodilator in horses with ‘heaves’

Cited by 5 publications

References 13 publications

Plasma and urinary concentrations of trimetoquinol by LC‐MS‐MS following intravenous and intra‐tracheal administration to horses with heaves

Plasma and urinary concentrations of trimetoquinol by LC‐MS‐MS following intravenous and intra‐tracheal administration to horses with heaves

Novel drug delivery systems and disease models for pulmonary fibrosis

Catecholamine Derivatives: Natural Occurrence, Structural Diversity, and Biological Activity

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