Radiotherapy is widely used in the clinical treatment of cancer patients and it may be used alone or in combination with surgery or chemotherapy to inhibit tumor development. However, radiotherapy may at times not kill all cancer cells completely, as certain cells may develop radioresistance that counteracts the effects of radiation. The emergence of radioresistance is associated with the genetic background and epigenetic regulation of cells. p53 is an important tumor suppressor gene that is expressed at low levels in cells. However, when cells are subjected to stress-induced stimulation, the expression level of p53 increases, thereby preventing genomic disruption. This mechanism has important roles in maintaining cell stability and inhibiting carcinogenesis. However, mutation and deletion destroy the anticancer function of p53 and may induce carcinogenesis. In tumor radiotherapy, the status of p53 expression in cancer cells has a close relationship with radiotherapeutic efficacy. Therefore, understanding how p53 expression affects the cellular response to radiation is of great significance for solving the problem of radioresistance and improving radiotherapeutic outcomes. For the present review, the literature was searched for studies published between 1979 and 2021 using the PubMed database (
) with the following key words: Wild-type p53, mutant-type p53, long non-coding RNA, microRNA, gene mutation, radioresistance and radiosensitivity. From the relevant studies retrieved, the association between different p53 mutants and cellular radiosensitivity, as well as the molecular mechanisms of p53 affecting the radiosensitivity of cells, were summarized. The aim of the present study was to provide useful information for understanding and resolving radioresistance, to help clinical researchers develop more accurate treatment strategies and to improve radiotherapeutic outcomes for cancer patients with p53 mutations.
ferromagnetic structures, particularly the anti-eddy plate, in a bi-planar permanent-magnet-type low-field (0.05 T) magnetic resonance imaging (MRI) brain scanner can distort the gradient field in the target region. This study aims to provide a new gradient coil design method that reduces ferromagnetic influences on gradient field linearity. Thus, a simplified model of electromagnetic (EM) structures of the permanent-magnet-type MRI scanners was established. By using precise analytical proof, the anti-eddy plate was reduced to a homogeneous magnetic plate. The overall effects of the EM structures, which can be represented by bi-planar magnetic plates, were evaluated. In sequence, the image magnetic dipole was first introduced to show the effects of anti-eddy plates were added to the conventional equivalent magnetic dipole (EMD) approach. A novel equivalent image magnetic dipole (EIMD) method was proposed to build the gradient coil pattern. The effect of ferromagnetic materials was predicted throughout the gradient coil design phase using the proposed method, and a high-linear gradient field was generated under real working conditions. The computational and experimental results showed that the gradient coil was linear when ferromagnetic structures were present. The effectiveness of the proposed method was demonstrated by comparing T1-weighted images of the conventional method to those of the proposed method. The proposed method reduced image distortion caused by nearby EM structures in bi-planar permanent-magnet-type lowfield MRI systems and provided an effective and concise solution for gradient coil designs.
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