Intravenous administration of lidocaine directly acts on spinal dorsal horn and produces analgesic effect: An in vivo patch-clamp analysis

Kurabe, Miyuki; Furue, Hidemasa; Kohno, Tatsuro

doi:10.1038/srep26253

Cited by 38 publications

(27 citation statements)

References 49 publications

(70 reference statements)

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“…[ 7 ] Lidocaine IV administration produces an analgesic effect in various pain states, such acute postoperative pain, and neuropathic pain. [ 8 ]…”

Section: Introductionmentioning

confidence: 99%

Effect of intravenous lidocaine infusion on long-term postoperative pain after spinal fusion surgery

Ibrahim¹,

Aly²,

Farrag³

2018

Medicine

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Background:Intravenous lidocaine infusion is known to reduce postoperative pain for days or weeks beyond the infusion time, and plasma half-life in several types of surgical procedures.Objectives:To evaluate the effect of intravenous (IV) lidocaine infusion on long term postoperative pain intensity for 3 months in patients undergoing spinal fusion surgery.Study Design:Prospective randomized, double-blinded study.Setting:Assiut University Hospital, Assiut, Egypt.Methods:Forty patients undergoing spinal fusion surgery were randomized into 2 equal groups (n = 20 in each). Patients in the lidocaine group received IV lidocaine at a dosage of 2.0 mg/kg slowly before induction of anesthesia, followed by lidocaine IV infusion at a rate of 3.0 mg/kg/h until the end of surgery. Patients in the control group received an equal volume of normal saline. The following data were assessed: pain by Visual Analog Score (VAS) at 1 hour, 6 hours, 12 hours, 24 hours, 48 hours, at discharge time, and at 1 month, 2 months, and 3 months post-operation, time to first request for additional analgesia, and total morphine consumption in 24 hours.Results:Lidocaine significantly reduced the postoperative pain score (VAS) for up to 3 months (P < .05), and significantly reduced morphine consumption (4.5 mg vs. 19.85 mg) in the 1st 24 hours postoperative. Lidocaine also significantly, prolonged (P < .05) the time to first request for additional analgesia (9.56 ± 2.06 hours vs 1.82 ± 0.91 hours).Conclusion:Intra-operative lidocaine, when given intravenously as a bolus followed by an infusion, significantly decreased long term postoperative back pain intensity in patients undergoing spinal fusion surgery.

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“…[ 7 ] Lidocaine IV administration produces an analgesic effect in various pain states, such acute postoperative pain, and neuropathic pain. [ 8 ]…”

Section: Introductionmentioning

confidence: 99%

Effect of intravenous lidocaine infusion on long-term postoperative pain after spinal fusion surgery

Ibrahim¹,

Aly²,

Farrag³

2018

Medicine

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“…Voltage gated sodium channel (VGSC) Classic mechanism of action is through blockade of VGSC 17 ; Intravenous lignocaine may inhibit VGSC in peripheral nerves and/or dorsal root ganglia 23 ; Potassium channels Lignocaine effect on potassium channels is available through experimental evidence in animal models 60 ;…”

Section: Receptor/mechanism Actionmentioning

confidence: 99%

Perioperative intravenous lignocaine infusion for postoperative pain control in patients undergoing surgery of the spine: protocol for a systematic review and meta-analysis

Licina

Silvers

2020

BMJ Open

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IntroductionIntravenous lignocaine is an amide local anaesthetic known for its analgesic, antihyperalgesic and anti-inflammatory properties. Administration of intravenous lignocaine has been shown to enhance perioperative recovery parameters. This is the protocol for a systematic review which intends to summarise the evidence base for perioperative intravenous lignocaine administration in patients undergoing spinal surgery.Methods and analysisOur primary outcomes include: postoperative pain scores at rest and movement at predefined early, intermediate and late time points and adverse events. Other outcomes of interest include perioperative opioid consumption, composite morbidity, surgical complications and hospital length of stay. We will include randomised controlled trials, which compared intravenous lignocaine infusion vs standard treatment for perioperative analgesia. We will search electronic databases from inception to present; MEDLINE, EMBASE and Cochrane Library (Cochrane Database of Systematic Reviews and CENTRAL). Two team members will independently screen all citations, full-text articles and abstract data. The individual study risk of bias will be appraised using the Cochrane risk of bias tool. We will obtain a risk ratio or mean difference (MD) from the intervention and control group event rates based on the nature of data. We will correct for the variable measurement tools by using the standardised MD (SMD). We will use a random-effects model to synthesise data. We will conduct five subgroup analysis: major versus minor surgery, emergency versus elective surgery, patients with chronic pain conditions versus patients without, duration of lignocaine infusion and adult versus paediatric. Confidence in cumulative evidence for will be classified according to the Grading of Recommendations, Assessment, Development and Evaluation system. We will construct summary of findings tables supported detailed evidence profile tables for predefined outcomes.Ethics and disseminationFormal ethical approval is not required as primary data will not be collected. The results will be disseminated through a peer-reviewed publication.PROSPERO registration numberCRD420201963314

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“…Semua pasien yang masuk ke dalam kelompok perlakuan mengalami perbaikan kadar kalium setelah proses koreksi, sebagian besar pasien langsung mencapai kadar normokalemia, hanya sedikit pasien yang tidak mencapai normokalemia disebabkan karena pasien mengalami hipokalemia berat dan perlu memerlukan beberapa serial koreksi Penelitian sebelumnya menyebutkan jika pada nyeri-nyeri dengan intensitas yang lebih berat akan memerlukan pengaturan dosis dan akan memerlukan dosis yang lebih besar untuk dapat mengatasi nyeri. 25,26,27,28 Sehingga saat nyeri tetap muncul, klinisi perlu mengevaluasi dari dosis lidokain yang diberikan. Progresivitas nyeri yang dirasakan pasien, dapat ditanggulangi dengan menaikkan dosis lidokain yang diberikan.…”

Section: Abstrakunclassified

Efektivitas Lidokain Intravena untuk Mengurangi Nyeri pada Pemberian Drip KCl melalui Akses Vena Perifer

Azza¹,

Susianti²,

Agustin³

et al. 2020

JAI b

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Latar Belakang: Hipokalemia merupakan gangguan elektrolit yang sering terjadi. Hipokalemia berat dapat mengancam jiwa. Koreksi hipokalemi yang tepat dan cepat dapat mencegah komplikasi yang membahayakan jiwa. Salah satu intervensi yang dapat dilakukan adalah dengan pemberian KCl melalui akses vena perifer, tetapi KCl memiliki sifat iritatif yang dapat menyebabkan nyeri. Cara yang dapat dilakukan untuk mengurangi nyeri adalah dengan pemberian lidokain intravena. Lidokain merupakan obat anestesi yang dapat diberikan secara intravena dan memberikan efek analgesia. Tujuan: Mengetahui keefektifan lidokain untuk mengurangi nyeri pada pemberian KCl melalui akses vena perifer.Metode: Penelitian ini merupakan uji klinis randomisasi samar berganda melibatkan 37 pasien hipokalemia yang memerlukan koreksi. Pasien terbagi menjadi 21 pasien kelompok perlakuan (mendapatkan lidokain saat koreksi) dan 16 pasien kelompok kontrol (tanpa lidokain) yang kemudian penilaian nyeri menggunakan numering pain rating scale (NPRS) pada pertengahan proses koreksi (2,5 jam) dan akhir koreksi (5 jam). Hasil: Tidak terdapat perbedaan karakteristik dasar di kedua kelompok pada awal penelitian. Pemberian lidokain terbukti dapat mengurangi terjadinya nyeri dari proses koreksi kalium pada pertengahan proses koreksi dan akhir proses koreksi (p<0,05). Pada progresivitas nyeri, pemberian lidokain mampu mencegah terjadinya nyeri pada 2,5 jam pertama (RR=0,47, 95%IK 0,26-0,85, p=0,01) namun progresivitas nyeri 2,5 jam berikutnya tidak bermakna secara statistik (RR=0,95, 95%IK 0,30-2,99, p>0,05).Kesimpulan: Lidokain dapat mengurangi nyeri selama proses koreksi kalium sehingga dapat dipertimbangkan untuk diaplikasikan dalam praktik klinis.

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Intravenous administration of lidocaine directly acts on spinal dorsal horn and produces analgesic effect: An in vivo patch-clamp analysis

Cited by 38 publications

References 49 publications

Effect of intravenous lidocaine infusion on long-term postoperative pain after spinal fusion surgery

Effect of intravenous lidocaine infusion on long-term postoperative pain after spinal fusion surgery

Perioperative intravenous lignocaine infusion for postoperative pain control in patients undergoing surgery of the spine: protocol for a systematic review and meta-analysis

Efektivitas Lidokain Intravena untuk Mengurangi Nyeri pada Pemberian Drip KCl melalui Akses Vena Perifer

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