Intravenous acetaminophen for postoperative pain control after open abdominal and thoracic surgery in pediatric patients: a systematic review and meta-analysis

Archer, Victoria; Cloutier, Zacharie; Park, Lily; Briatico, Daniel; Walton, J. Mark

doi:10.1007/s00383-022-05282-0

Cited by 4 publications

(6 citation statements)

References 52 publications

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“…Studies have shown that both intravenous acetaminophen as well as dexmedetomidine can reduce use of opioids without increasing postoperative pain. [23][24][25] In this study, a downtrend in the use of benzodiazepines (i.e., midazolam, lorazepam) in the study epochs is reported. Recent publications have reported an association of intensive care unit-induced delirium in children, and it is not surprising that there is a downtrend in the use of benzodiazepines in the patient cohort.…”

Section: Discussionmentioning

confidence: 90%

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Trends in sedation‐analgesia practices in pediatric liver transplant patients admitted postoperatively to the pediatric intensive care unit: An analysis of data from the pediatric health information system (PHIS) database

Goldstein,

Jergel,

Karpen

et al. 2023

Pediatric Transplantation

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BackgroundChildren admitted to the pediatric intensive care unit (PICU), after liver transplantation, frequently require analgesia and sedation in the immediate postoperative period. Our objective was to assess trends and variations in sedation and analgesia used in this cohort.MethodsMulticenter retrospective cohort study using the Pediatric Health Information System from 2012 to 2022.ResultsDuring the study period, 3963 patients with liver transplantation were admitted to the PICU from 32 US children's hospitals with a median age of 2 years [IQR: 0.00, 10.00]. 54 percent of patients received mechanical ventilation (MV). Compared with patients without MV, those with MV were more likely to receive morphine (57% vs 49%, p < .001), fentanyl (57% vs 44%), midazolam (45% vs 31%), lorazepam (39% vs. 24%), dexmedetomidine (38% vs 30%), and ketamine (25% vs 12%), all p < .001. Vasopressor usage was also higher in MV patients (22% vs. 35%, p < .001). During the study period, there was an increasing trend in the utilization of dexmedetomidine and ketamine, but the use of benzodiazepine decreased (p < .001).ConclusionAbout 50% of patients who undergo liver transplant are placed on MV in the PICU postoperatively and receive a greater amount of benzodiazepines in comparison with those without MV. The overall utilization of dexmedetomidine and ketamine was more frequent, whereas the administration of benzodiazepines was less during the study period. Pediatric intensivists have a distinctive opportunity to collaborate with the liver transplant team to develop comprehensive guidelines for sedation and analgesia, aimed at enhancing the quality of care provided to these patients.

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Section: Discussionmentioning

confidence: 90%

“…Additionally, it is speculated that the use of intravenous acetaminophen and dexmedetomidine may also be responsible for the reduced use of opioids during the above time period. Studies have shown that both intravenous acetaminophen as well as dexmedetomidine can reduce use of opioids without increasing postoperative pain 23–25 …”

Section: Discussionmentioning

confidence: 99%

Trends in sedation‐analgesia practices in pediatric liver transplant patients admitted postoperatively to the pediatric intensive care unit: An analysis of data from the pediatric health information system (PHIS) database

Goldstein,

Jergel,

Karpen

et al. 2023

Pediatric Transplantation

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“…For example, an orderable for oral acetaminophen/hydrocodone would be specified for pain scale 1 to 5 while an orderable for IV morphine was reserved for pain scale 6 to 10. Additionally, nonopioid pharmacologic alternatives 21-25 like NSAIDs, acetaminophen, tramadol, gabapentin, tapentadol, and nerve block agents (bupivacaine, ropivacaine) were included in the revised PowerPlans at WCH. Based on patient’s perceived pain intensity, these agents fully or partially substituted opioids as the choice of drug for pain management prescribed by providers.…”

Section: Discussionmentioning

confidence: 99%

Trends of Opioid Usage in Surgical Patients in a Small Community Hospital: Analysis of Patient Data Between 2017 and 2021

Leopold,

Gerschutz,

Rao

2023

Hosp Pharm

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Purpose: The purpose of our study was to quantify and analyze the annual opioid usage in surgical patients at Wood County Hospital (WCH) between 2017 and 2021. Methods: In this retrospective study, patient data between 2017 and 2021 was analyzed to determine the oral morphine milligram equivalent (MME) of opioids used in surgical patients at WCH. Annual MME prescribed per admission was compared each year using one-way ANOVA followed by Tukey post hoc test. Similarly, the annual use of intravenous (IV) acetaminophen for surgical patients per admission was also calculated and analyzed using the one-way ANOVA followed by Tukey post hoc test. Results: Compared to the year 2017 (42.0 ± 3.6), a statistically significant decrease in opioid usage per surgical admission (mean±SEM of MME) was observed during the years 2018 (32.6 ± 1.4; P = .04), 2019 (30.4 ± 1.2; P = .01), and 2021 (30.8 ± 1.9; P = .01). An analysis of individual opioid use revealed a trend toward lower fentanyl and hydromorphone usage each year since 2017. A significant decrease in the annual morphine usage (mean±SEM of MME) for surgical patients was observed during both 2020 (14.4 ± 0.9; P = .05) and 2021 (14.0 ± 0.7; P = .05) compared to the year 2017 (22.1 ± 2.4). Finally, compared to the year 2017, a statistically significant decrease ( P < .05) in the annual use of oxycodone (MME) and IV acetaminophen (mg) for pain management in surgical patients was observed from 2018 to 2021. Conclusion: Our analysis reveals a significant decrease in opioid usage per surgical admission at WCH over 2017 to 2021 indicating a positive impact of the various opioid stewardship measures implemented at the hospital.

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“…Furthermore, all available trials suffer from short follow-up periods, with the median follow-up time being 48 hours. Recovery after major surgery extends well beyond this time; prolonged follow-up times are needed to capture the entire postoperative period [36]. While there may be clinical benefits, IV acetaminophen is expensive.…”

Section: Plos Onementioning

confidence: 99%

Intravenous acetaminophen for postoperative pain in the neonatal intensive care unit: A protocol for a pilot randomized controlled trial (IVA POP)

Archer,

Samiee-Zafarghandy,

Farrokyhar

et al. 2023

PLoS ONE

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Background In neonates, uncontrolled pain and opioid exposure are both correlated with short- and long-term adverse events. Therefore, managing pain using opioid-sparing approaches is critical in neonatal populations. Multimodal pain control offers the opportunity to manage pain while reducing short- and long-term opioid-related adverse events. Intravenous (IV) acetaminophen may represent an appropriate adjunct to opioid-based postoperative pain control regimes. However, no trials assess this drug in patients less than 36 weeks post-conceptual age or weighing less than 1500 g. Objective The proposed study aims to determine the feasibility of conducting a randomized control trial to compare IV acetaminophen and fentanyl to a saline placebo and fentanyl for patients admitted to the neonatal intensive care unit (NICU) undergoing major abdominal or thoracic surgery. Methods and design This protocol is for a single-centre, external pilot randomized controlled trial (RCT). Infants in the NICU who have undergone major thoracic or abdominal surgery will be enrolled. Sixty participants will undergo 1:1 randomization to receive intravenous acetaminophen and fentanyl or saline placebo and fentanyl. After surgery, IV acetaminophen or placebo will be given routinely for eight days (192 hours). Appropriate dosing will be determined based on the participant’s gestational age. Patients will be followed for eight days after surgery and will undergo a chart review at 90 days. Primarily feasibility outcomes include recruitment rate, follow-up rate, compliance, and blinding index. Secondary clinical outcomes will be collected as well. Conclusion This external pilot RCT will assess the feasibility of performing a multicenter RCT comparing IV acetaminophen and fentanyl to a saline placebo and fentanyl in NICU patients following major abdominal and thoracic surgery. The results will inform the design of a multicenter RCT, which will have the appropriate power to determine the efficacy of this treatment. Trial registration ClinicalTrials.gov NCT05678244, Registered December 6, 2022.

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Intravenous acetaminophen for postoperative pain control after open abdominal and thoracic surgery in pediatric patients: a systematic review and meta-analysis

Cited by 4 publications

References 52 publications

Trends in sedation‐analgesia practices in pediatric liver transplant patients admitted postoperatively to the pediatric intensive care unit: An analysis of data from the pediatric health information system (PHIS) database

Trends in sedation‐analgesia practices in pediatric liver transplant patients admitted postoperatively to the pediatric intensive care unit: An analysis of data from the pediatric health information system (PHIS) database

Trends of Opioid Usage in Surgical Patients in a Small Community Hospital: Analysis of Patient Data Between 2017 and 2021

Intravenous acetaminophen for postoperative pain in the neonatal intensive care unit: A protocol for a pilot randomized controlled trial (IVA POP)

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