Intravascular malignant lymphomatosis (angiotropic large‐cell lymphoma). A case report with evidence for T‐cell lineage with polymerase chain reaction analysis

Lakhani, Sunil R.; Hulman, G.; Hall, J.M.; Slack, D. N.; Sloane, J P

doi:10.1111/j.1365-2559.1994.tb01331.x

Cited by 29 publications

(23 citation statements)

References 5 publications

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“…A total of 18 B-cell AL cases from the Cleveland Clinic Foundation, Cleveland, Ohio (cases 1-6 and 16 -18, 1986 -2000), the City of Hope National Medical Center, Duarte, California (7-10, 1989 -1997), and the Cross Cancer Center, Edmonton, Alberta (11)(12)(13)(14)(15)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998) were studied (Table 1). Of the 11 patients diagnosed in life, there was available follow up in eight.…”

Section: Casesmentioning

confidence: 99%

Angiotropic Lymphoma: An Immunophenotypically and Clinically Heterogeneous Lymphoma

Coupland²,

et al. 2001

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Angiotropic lymphoma (AL) is an uncommon lymphoma often presenting with nonspecific clinical features and having a high mortality rate. Although not specifically recognized by the Revised European-American Classification of Lymphoid Neoplasms, it likely will appear as a subtype of diffuse large B-cell lymphoma in the upcoming WHO classification. Some authors may also consider it to be a subtype of cutaneous lymphomas. Recent studies have reported an immunophenotypic heterogeneity of AL, and in rare instances, an association with other NHL. To further characterize AL, we studied the immunophenotype by immunohistochemistry for CD5, CD10, CD20, bcl-2, and bcl-6 in 18 cases of B-cell AL identified at three medical centers in North America. Bcl-2 gene rearrangement status by polymerase chain reaction and Epstein Barr virus status by in situ hybridization also were evaluated.Eight men and 10 women were identified with AL (median age 71 years). Eleven patients were diagnosed in life and seven were diagnosed at autopsy. Neurologic symptoms were the most common presentation, seen in six patients. Skin was the most commonly biopsied site. All showed classic intravascular localization; in two cases, there was also a minor diffuse large cell lymphoma component observed in some organs. Most (89%) of the cases expressed bcl-2 protein; CD10, bcl-6 and CD5 were each expressed in 22% of cases. Based on CD5 and CD10 expression, three major groups were evident: CD5؊, CD10؊ (11 cases); CD5؉, CD10؊ (3 cases), and CD5؊, CD10؉ (3 cases). Even though a follicle center lymphoma preceded the AL in one patient, we did not detect bcl-2 gene rearrangement in any of these cases. All cases were negative for Epstein Barr virus. Of the five treated with chemotherapy, two achieved a complete remission.Based on these findings, we conclude that ALs are clinically and immunophenotypically heterogeneous and may represent more than one pathogenetic entity. In some instances AL may be preceded by another lymphoproliferative disorder, raising the possibility that some cases of AL may represent a transformation from another type of lymphoma. Cutaneous manifestations of AL are common; however, it appears to be a systemic lymphoma. Although often fatal, patients with AL who are diagnosed early and treated with chemotherapy may achieve remission.

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Section: Casesmentioning

confidence: 99%

Angiotropic Lymphoma: An Immunophenotypically and Clinically Heterogeneous Lymphoma

Coupland²,

et al. 2001

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“…The immunophenotype of most cases of IVL is usually established using immunohistochemical studies, and several studies have identified more than one population of lymphoid cells, with the predominant cell type reported as the IVL cell of origin. Few studies have confirmed clonality with PCR technique [26]. This may indicate that the T-cell phenotype is either under-reported or not distinguished from B-cell phenotype on pathology.…”

Section: Discussionmentioning

confidence: 99%

Intravascular T-cell lymphoma with bowel involvement: Case report and literature review

et al. 2005

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Intravascular lymphoma (IVL) is a rare form of non-Hodgkin lymphoma characterized by massive proliferation of large, neoplastic cells in small-and medium-sized blood vessels. Most cases of IVL are of B-cell immunophenotype; fewer than 15 cases of T-cell IVL have been reported. A 23-year-old male presented with acute abdominal pain, fever, and tender lower abdomen. Pathology at laparotomy revealed infiltration of colonic vessels with large lymphoid cells compatible with IVL. We reviewed all cases of IVL diagnosed at the Queen Elizabeth II Health Sciences Centre in Halifax, Nova Scotia, from August 1992 to August 2002. A literature review was also performed. Five additional cases of IVL were identified at this institution during a 10-year period. Three patients presented with neurological symptoms, and two with abdominal pain. In 4 of 5 cases, patients died of lymphoma within 3 months of presentation; one patient experienced a 10-month remission. While visceral involvement with IVL is common at autopsy, IVL presenting as an acute abdomen in an immunocompetent patient has not previously been described. Among the 15 cases of T-cell IVL reported in the literature, only two occurred in people under age 30. Given the rarity of T-cell IVL, it is remarkable that three cases of T-cell IVL have been diagnosed at our institution during a 10-year period. Am.

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“…As far as we know and according to the available literature, liver and bone marrow biopsies have never been reported as being primary sites of ALCL. However, some authors [1,4,9,10] found in autopsy cases hepatic and bone marrow involvement as part of dissemination of ALCL.…”

Section: Discussionmentioning

confidence: 99%

“…Other organs as primary sites of this neoplasm are rare, although when the disease advances it may often spread to different internal organs [1, 4-6, 9, 10, 16]. The liver and bone marrow can be occasionally in- volved, but all such cases are discovered at autopsy only [1,4,9,10]. In this report, we describe an unusual case of ALCL discovered in biopsy specimens from the liver and bone marrow.…”

Section: Introductionmentioning

confidence: 93%

“…In the past, there has been a controversy with regard to the origin of these neoplastic cells [6,16]. Originally described as being endothelial [13], these cells were recently confirmed to be of lymphoid lineage, mostly of B-cell and occasionally of T-cell phenotype [1,3,5,10,11,15,16]. Some investigators proposed that the lymphocyteendothelial cell homing mechanism, including deficiency of homing receptors CDI la/ CD18, may be responsible for settling of the neoplastic cells in the small blood vessels [5,6,10,15].…”

Section: Discussionmentioning

confidence: 99%

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A Case of Angiotropic Large Cell Lymphoma Primarily Discovered in Biopsy Specimens from Liver and Bone Marrow

Kahvić¹,

Nayak

Mokhtar³

et al. 1999

Med Princ Pract

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Objective and Importance: We describe an unusual site for angiotropic large cell lymphoma (ALCL) diagnosed from liver and bone marrow biopsy specimens. ALCL is a rare, multifocal, exclusively intravascular and generally fatal disorder of high-grade non-Hodgkin’s lymphoma. Clinical Presentation: The patient, a 70-year-old woman, presented with hepatosplenomegaly, anaemia, and disturbed liver function tests. Conclusion: As far as we know, and according to the available literature, liver and bone marrow biopsies have never been reported as being primary sites of ALCL.

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Intravascular malignant lymphomatosis (angiotropic large‐cell lymphoma). A case report with evidence for T‐cell lineage with polymerase chain reaction analysis

Cited by 29 publications

References 5 publications

Angiotropic Lymphoma: An Immunophenotypically and Clinically Heterogeneous Lymphoma

Angiotropic Lymphoma: An Immunophenotypically and Clinically Heterogeneous Lymphoma

Intravascular T-cell lymphoma with bowel involvement: Case report and literature review

A Case of Angiotropic Large Cell Lymphoma Primarily Discovered in Biopsy Specimens from Liver and Bone Marrow

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