Intravascular Coagulation and Pre-Eclamptic Toxæmia

Preston, F. E.; Malia, R. G.; Tipton, Richard H.; Smith, Austin

doi:10.1016/s0140-6736(72)90020-7

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…Coagulation disorders secondary to disseminated intravascular coagulation have been described in toxaemia (3, 23,24,27), in the dead fetus syndrome (24) and abruptio placentae (25,27). In the 2 patients described in this paper coagulation disturbances were found as early as the 27th week of pregnancy.…”

Section: Discussionmentioning

confidence: 73%

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Intravascular Coagulation in Pregnancy‐Treatment with Heparin

Nilsson

Hedner

Åstedt

et al. 1975

Acta Obstet Gynecol Scand

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Two pregnant women with a history of miscarriages or premature labour are described. In the 25-27th week of pregnancy routine examinations showed high levels of FDP in serum. Subsequent extensive coaggulation studies revealed a positive ethanol gelation test, low levels of firbrinogen, plasminogen, alpha2-macroglobulin and P&P and high level of AHF related protein for the stage of pregnancy, i.e. finding indicating abnormal proteolysis with activation of the coagulation and fibrinolytic system. Continuous intravenous heparin treatment caused the coagulation system to return to normal throughout the rest of pregnancy. Both women gave birth to healthy babies without any complications. But the placenta showed numerous infarcts. The heparin treatment may have prevented later developing of placental dysfunction.

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Section: Discussionmentioning

confidence: 73%

“…Disseminated intravascular coagulation has been reported to occur in pregnant women with preeclamptic toxaemia and eclampsia (3,15,23,25,26). Fibrin deposits in the kidney, liver and lungs have been demonstrated in these conditions (16,25,27) as well as increased fibrinogen catabolism (27).…”

mentioning

confidence: 99%

Intravascular Coagulation in Pregnancy‐Treatment with Heparin

Nilsson

Hedner

Åstedt

et al. 1975

Acta Obstet Gynecol Scand

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“…In pre-eclampsia intravascular coagulation is intensified ; fibrinogen degradation products (FDP) increase both in the blood (Henderson et al 1970, McKillop et al 1976) and urine (Preston et al 1972), the platelet count tends to fall (Bonnar et al 1971, Starkie et al 1971) and there is rise in the mean platelet volume , Giles & Inglis 1981.…”

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confidence: 99%

Intravascular coagulation in gestational hypertension and pre-eclampsia: the value of haematological screening tests

Giles¹

2008

Clinical &Amp; Laboratory Haematology

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Summary. Routine investigations designed to detect excessive intravascular coagulation in patients with gestational hypertension and pre‐eclampsia have been analysed in 936 cases. Reticulocyte counts did not differ significantly from those in normal controls and abnormal red cell morphology was detected in only two patients. Fibrinogen degradation products and thrombocytopenia were found in about 10% of all hypertensive women and macrothrombocytosis in 32%. Neither reticulocyte counts nor the scanning of stained blood films for evidence of microangiopathic haemolysis have a place in the routine investigation of preeclampsia and it is doubtful whether any of the other screening tests can influence the management of patients with uncomplicated gestational hypertension. In fully developed pre‐eclampsia, macrothrombocytosis is found in about 50% of patients, fibrinogen degradation products and thrombocytopenia in about 15%. All three parameters reflect the degree of clinical severity of the disease.

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