Intravascular B‐cell lymphoma with leukemic presentation: case report and literature review

Abstract

Intravascular lymphoma is an extremely rare, disseminated, and aggressive extranodal CD20+ non-Hodgkin's lymphoma characterized by the presence of lymphoma cells only in the lumina of small vessels. We report a 72-year-old woman with a diagnosis of intravascular lymphoma presented with splenomegaly and leukemic appearance in the peripheral blood smear. Her clinical course was rapidly deteriorated before the initiation of specific chemotherapy and finally died due to multiorgan insufficiency. Bone marrow biopsy revealed a characteristic infiltration of CD5, CD10 B-cell lymphoma. To our knowledge, this is the first reported case of a CD5, CD10 intravascular B-cell lymphoma with leukemic presentation in peripheral blood with multiple cytogenetic aberrations.

A Clinical Triad with Fatal Implications: Recrudescent Diffuse Large B-cell Non-Hodgkin Lymphoma Presenting in the Leukemic Phase with an Elevated Serum Lactic Acid Level and Dysregulation of the TP53 Tumor Suppressor Gene – A Case Report and Literature Review

“…Using a Medline search with the key words "diffuse large B-cell lymphoma AND leukemic/leukemic phase" and "diffuse large B-cell lymphoma AND leukemic/leukemic presentation", we identified a total of 16 case reports and 2 case series of de novo or relapsed DLBCL presenting in the leukemic phase that were published in English (Table 1). [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] In one case series describing the clinical course of 40 individuals with leukemic presentations of de novo DLBCL, 32 (80%) patients died with a median follow-up of 18 months. 23 The median follow-up for the 8 surviving patients was 34.5 months.…”

“…Cyclin D1 on the bone marrow biopsy was negative by immunohistochemistry. Cytogenetic analysis from culture stimulated with IL2 and DSP30 in lymphoid cells showed an abnormal male karyotype, characterized by 45~47, XY, −1, −2, −4, −5, del(6)(q10), add(7) (p11.2), −9, +7~9mar, inc[cp2]/46, XY [18]. He received empiric broad-spectrum antibiotics and antifungal coverage, but an extensive fever workup, including bronchoalveolar lavage, multiple serological tests, and assorted cultures of various bodily fluids showed no infectious pathogens.…”

Leukemic cells segmentation algorithm based on molecular spectral imaging technology

“…In clinical practice, recognition and classification of blood cells is helpful for doctors to identify different leukemic diseases. One commonly way to study this disease is employing an optical microscope to observe blood smears [16]. However, this method can only receive qualitative analysis results, and it is a time and labor consuming work.…”