Intrauterine injection of human chorionic gonadotropin before embryo transfer may improve clinical pregnancy and implantation rates in blastocysts transfers

The effect of intrauterine HCG injection on IVF outcome: a systematic review and meta-analysis

“…For example, two studies included donor cycles in the inclusion criteria (Cambiaghi et al, 2013;Santibáñez et al, 2014), whreas other studies have combined fresh and frozen embryo transfers in their analysis (Hong et al, 2014;Santibáñez et al, 2014). Other factors that also warrant caution are the variation in the type of HCG used (urinary or recombinant), the volume of fluid infused (0.02-0.5 ml) as well as the time interval between HCG infusion and embryo transfer (which ranged between 3 min to 48 h).…”

“…In total, 1614 women were randomized to treatment with intrauterine HCG and 1473 women were randomized not to receive intrauterine HCG at the time of embryo transfer. Out of the eight studies, two were published as oral conference abstracts (Cambiaghi et al, 2013;Janati et al, 2014). Risk of bias in the included trials is represented in Figures 2 and 3.…”

“…Seven studies (Aaleyasin et al, 2015;Cambiaghi et al, 2013;Hong et al, 2014;Janati et al, 2014;Mansour et al, 2011;Santibáñez et al, 2014;Wirleitner et al, 2015) used a dose of 500 IU of HCG and reported CPR. Pooling of the results of these studies (n = 2544) showed a statistically significant difference in CPR with the use of intrauterine HCG compared with no HCG (RR 1.21; 95% CI 1.01 to 1.46; P = 0.04) (Figure 8).…”