Intrauterine infection and prematurity

Abstract

Intrauterine infection is a major cause of premature labor with and without intact membranes. Intrauterine infection is present in approximately 25% of all preterm births and the earlier the gestational age at delivery, the higher the frequency of intra-amniotic infection. Microorganisms may also gain access to the fetus before delivery. A fetal inflammatory response syndrome elicited in response to microbial products is associated with the impending onset of preterm labor and also with multi-systemic organ involvement in the human fetus and a higher rate of perinatal morbidity. The most common microorganisms involved in intrauterine infections are Ureaplasma urealyticum, Fusobacterium species and Mycoplasma hominis. The role of Chlamydia trachomatis and viruses in preterm labor remain to be determined. Use of molecular microbiology techniques to diagnose intrauterine infection may uncover the role of fastidious microorganisms that have not yet been discovered. Antibiotic administration to patients with asymptomatic bacteriuria is associated with a significant reduction in the rate of preterm birth. However, such benefit has not been demonstrated for patients with bacterial vaginosis, or women who carry Streptococcus agalactia, Ureaplasma urealyticum or Trichomonas vaginalis. Antibiotic administration to patients with preterm premature rupture of membranes is associated with prolongation of pregnancy and a reduction in the rate of clinical chorioamnionitis and neonatal sepsis. The benefit has not been demonstrated in patients with preterm labor and intact membranes. Major efforts are required to determine why some women develop an ascending intrauterine infection and others do not and also what interventions may reduce the deleterious effect of systemic fetal inflammation.

Maternal Infection and Risk of Cerebral Palsy in Term and Preterm Infants

“…Maternal infection is a common cause of preterm birth, [23][24][25] as well as CP. However, preterm birth may be associated with CP through other, noninflammatory mechanisms as well.…”

Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes

“…Synthetic glucocorticoids, such as dexamethesone (DEX) mimic the endogenous cortisol rise and induce parturition and pre-term birth [20]. Intrauterine infection is another major risk factor for preterm labour [24]. The bacterial endotoxin lipopolysaccharide (LPS) increases the activities of phospholipase (PL)A2 and PTGS2, and inhibits PGDH [25,26].…”

Experimental amniotic fluid infection in sheep: Effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep

“…Ureaplasmas are the microorganisms most frequently associated with preterm birth (1)(2)(3), and their presence in amniotic fluid or the neonatal lungs influences an infant's risk of pulmonary disease (4,5). We demonstrated previously that intra-amniotic injection of Ureaplasma parvum serovar 3 results in amniotic and fetal pulmonary colonization, and induces functional 'maturation' of the preterm lungs in sheep (6).…”