Intrauterine human chorionic gonadotropin (HCG) infusion prior to embryo transfer (ET) may be detrimental to pregnancy rate

Volovsky, Michelle; Healey, Martin; MacLachlan, Vivien; Vollenhoven, Beverley

doi:10.1016/j.fertnstert.2016.07.160

Fertility and Sterility

2016

DOI: 10.1016/j.fertnstert.2016.07.160

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Intrauterine human chorionic gonadotropin (HCG) infusion prior to embryo transfer (ET) may be detrimental to pregnancy rate

Michelle Volovsky

Martin Healey

Vivien MacLachlan

et al.

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“…", or "How can we achieve optimal receptivity of the endometrium?" It was not long before a hypothesis was formed questioning whether hCG administration via intrauterine infusion prior to the embryo transfer (ET) procedure may offer a noteworthy solution to implantation failure, resulting to superior pregnancy outcomes (9).…”

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confidence: 99%

Investigating the Optimal Time for Intrauterine Human Chorionic Gonadotropin Infusion in Order to Improve IVF Outcome: A Systematic Review and Meta-Analysis

Simopoulou

Sfakianoudis²,

Maziotis

et al. 2019

In Vivo

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Background/Aim: Studies on the impact of intrauterine human Chorionic Gonadotropin (hCG) administration in order to improve the In Vitro Fertilization (IVF) outcome have yielded conflicting results. The aim of the present systematic review and meta-analysis is to investigate whether timing of intrauterine hCG administration prior to embryo transfer affects its efficiency. Materials and Methods: A systematic search of the literature on Pubmed/Medline, Embase and Cochrane databases was performed. Only Randomized Control Trials were included in this metaanalysis. Results: Live birth rates were not improved following hCG administration (RR=1.13, 95%CI=0.88-1.46, p=0.34) in the pooled results. Combined live birth and ongoing pregnancy rates were borderline statistically significant following hCG administration (RR=1.27, 95%CI=1.00-1.62, p=0.05). Following subgroup analysis regarding live birth and ongoing pregnancy rates, only the 5-12 minutes prior to the embryo transfer group reported a statistically significant improvement. Conclusion: Intrauterine infusion of hCG within an IVF-Intracytoplasmic Sperm Injection (ICSI) cycle improves outcome only when administered 5-12 min prior to embryo transfer.

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mentioning

confidence: 99%

Investigating the Optimal Time for Intrauterine Human Chorionic Gonadotropin Infusion in Order to Improve IVF Outcome: A Systematic Review and Meta-Analysis

Simopoulou

Sfakianoudis²,

Maziotis

et al. 2019

In Vivo

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Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction

Craciunas

Tsampras

Raine‐Fenning

et al. 2018

Cochrane Database of Systematic Reviews

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Intrauterine human chorionic gonadotropin (HCG) infusion prior to embryo transfer (ET) may be detrimental to pregnancy rate

Cited by 2 publications

References 0 publications

Investigating the Optimal Time for Intrauterine Human Chorionic Gonadotropin Infusion in Order to Improve IVF Outcome: A Systematic Review and Meta-Analysis

Investigating the Optimal Time for Intrauterine Human Chorionic Gonadotropin Infusion in Order to Improve IVF Outcome: A Systematic Review and Meta-Analysis

Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction

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