Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction

Craciunas, Laurentiu; Tsampras, Nikolaos; Raine‐Fenning, Nick; Coomarasamy, Arri

doi:10.1002/14651858.cd011537.pub3

Cited by 30 publications

(36 citation statements)

References 46 publications

(6 reference statements)

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“…19,20 Intriguingly, hCG promotes uterine NK cell proliferation through mannose receptors but not through LH/ CG-R because NK cells do not express LH/CG-R. [23][24][25] However, there is no consensus regarding the level of efficacy or the most responsive patient populations to this treatment. A clinical trial has suggested that intrauterine administration of autologous peripheral blood mononuclear cells (PBMCs) activated by hCG increases the implantation and pregnancy rates in patients with repeated implantation failure.…”

Section: Introductionmentioning

confidence: 99%

Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells

Diao

Zhu

et al. 2017

Am J Reprod Immunol

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Section: Introductionmentioning

confidence: 99%

Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells

Diao

Zhu

et al. 2017

Am J Reprod Immunol

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“…Many studies in recent years have investigated the impact of this intrauterine hCG administration before embryo transfer in patients with repeated implantation failures. The results of these studies are controversial (153)(154)(155). The differences in design and population can explain the contradictory results.…”

Section: Infusion Of Hcg During Embryo Transfermentioning

confidence: 99%

Human Chorionic Gonadotrophin: New Pleiotropic Functions for an “Old” Hormone During Pregnancy

et al. 2020

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Human chorionic gonadotrophin (hCG) is the first specific molecule synthesized by the embryo. hCG RNA is transcribed as early as the eight-cell stage, and the blastocyst produces the protein before its implantation. hCG in the uterine microenvironment binds with its cognate receptor, luteinizing hormone/choriogonadotropin receptor (LHCGR), on the endometrial surface. This binding stimulates leukemia inhibitory factor (LIF) production and inhibits interleukin-6 (IL-6) production by epithelial cells of the endometrium. These effects ensure essential help in the preparation of the endometrium for initial embryo implantation. hCG also effects angiogenic and immunomodulatory actions as reported in many articles by our laboratories and other ones. By stimulating angiogenesis and vasculogenesis, hCG provides the placenta with an adequate maternal blood supply and optimal embryo nutrition during the invasion of the uterine endometrium. The immunomodulatory properties of hCG are numerous and important for programming maternal immune tolerance toward the embryo. The reported effects of hCG on uterine NK, Treg, and B cells, three major cell populations for the maintenance of pregnancy, demonstrate the role of this embryonic signal as a crucial immune regulator in the course of pregnancy. Human embryo rejection for hCG-related immunological reasons has been studied in different ways, and a sufficient dose of hCG seems to be necessary to maintain maternal tolerance. Different teams have studied the addition of hCG in patients suffering from recurrent miscarriages or implantation failures. hCG could also have a beneficial or a negative impact on autoimmune diseases during pregnancy. In this review, we will discuss the immunological impacts of hCG during pregnancy and if this hormone might be used therapeutically.

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“…In a recent Cochrane review from Craciunas et al (45), it is proposed that in particular patients undergoing cleavage-stage embryo transfer receiving an hCG dosage above 500 IU benefit from intrauterine hCG injection but not patients undergoing blastocyst transfer. The last meta-analysis from 2019 concluded that intrauterine hCG administration before embryo transfer could significantly improve IR, CPR, OPR, and LBR and significantly lowered the MR.…”

Section: Clinical Application Of Hcg In Artificial Reproductive Technmentioning

confidence: 99%

Human Chorionic Gonadotropin-Mediated Immune Responses That Facilitate Embryo Implantation and Placentation

Schumacher

Zenclussen

2019

Front. Immunol.

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Human chorionic gonadotropin (hCG) serves as one of the first signals provided by the embryo to the mother. Exactly at the time when the first step of the implantation process is initiated and the blastocyst adheres to the maternal endometrium, the embryonic tissue starts to actively secrete hCG. Shortly thereafter, the hormone can be detected in the maternal circulation where its concentration steadily increases throughout early pregnancy as it is continuously released by the forming placenta. Accumulating evidence underlines the critical function of hCG for embryo implantation and placentation. hCG not only regulates biological aspects of these early pregnancy events but also supports maternal immune cells in their function as helpers in the establishment of an adequate embryo-endometrial relationship. In view of its early presence in the maternal circulation, hCG has the potential to influence both local uterine immune cell populations as well as peripheral ones. The current review aims to summarize recent literature on the participation of innate and adaptive immune cells in embryo implantation and placentation with a specific focus on their regulation by hCG.

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Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction

Abstract: Newcastle University ePrints-eprint.ncl.ac.uk Craciunas L, Tsampras N, Coomarasamy A, Raine-Fenning N. Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction.

Cited by 30 publications

References 46 publications

Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells

Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells

Human Chorionic Gonadotrophin: New Pleiotropic Functions for an “Old” Hormone During Pregnancy

Human Chorionic Gonadotropin-Mediated Immune Responses That Facilitate Embryo Implantation and Placentation

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