Intrauterine exposure to high saturated fat diet elevates risk of adult‐onset chronic diseases in C57BL/6 mice

Liang, Chengya; Oest, Megan E.; Prater, M. Renée

doi:10.1002/bdrb.20206

Cited by 99 publications

(82 citation statements)

References 43 publications

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“…Evidence from animal studies for programming of obesity An increasing number of studies in rodents show that exposure to maternal obesity/overnutrition during both pregnancy and lactation is associated with the development of obesity in the offspring (Guo & Jen 1995, Levin & Govek 1998, Bayol et al 2007, 2008, Samuelsson et al 2008, Shankar et al 2008, Liang et al 2009, Nivoit et al 2009, Tamashiro et al 2009, Yan et al 2010. This predisposition to obesity is amplified when offspring are themselves exposed to highly palatable or high-fat diets following weaning (Khan et al 2003, 2004, Bayol et al 2007).…”

Section: Programming Of Obesity and Body Compositionmentioning

confidence: 99%

“…In animal studies, exposure to maternal obesity/overnutrition during both pregnancy and lactation is associated with the development of metabolic dysfunction in offspring, including hyperinsulinaemia, hyperglycaemia and increased plasma levels of triglycerides, cholesterol and leptin, features that are amplified when offspring are themselves exposed to a high-fat diet (Guo & Jen 1995, Bayol et al 2008, Samuelsson et al 2008, Shankar et al 2008, Liang et al 2009, Nivoit et al 2009, Tamashiro et al 2009, Yan et al 2010. Additionally, there appears to be an age-related decline in glucose/insulin homoeostasis in many programming models; in mice, offspring of obese mothers were found to be hyperinsulinaemic at 3 months of age (young adulthood), but male offspring had developed frank diabetes with reduced plasma insulin and decreased pancreatic insulin content by 6 months of age (Samuelsson et al 2008).…”

Section: Glucose/insulin Homoeostasis and Pancreatic Functionmentioning

confidence: 99%

“…A number of rodent studies have demonstrated that the offspring of mothers maintained on a high-fat diet before and during pregnancy and through lactation develop high blood pressure (BP; Khan et al 2003, Samuelsson et al 2008, 2010, Elahi et al 2009, Liang et al 2009), which deteriorates further with age (Samuelsson et al 2008, Liang et al 2009). Khan et al (2005) cross-fostered offspring of obese rat mothers onto normal controls and showed that exposure to maternal obesity/high-fat diet during gestation was sufficient to programme hypertension in the offspring.…”

Section: Programming Of Blood Pressure and Vascular Functionmentioning

confidence: 99%

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Impact of maternal obesity on offspring obesity and cardiometabolic disease risk

Drake¹,

Reynolds²

2010

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442

308

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The prevalence of obesity among pregnant women is increasing. In addition to the short-term complications of obesity during pregnancy in both mother and child, it is now recognised that maternal obesity has long-term adverse outcomes for the health of her offspring in later life. Evidence from both animal and human studies indicates that maternal obesity increases the risk for the offspring in developing obesity and altering body composition in child-and adulthood and, additionally, it also has an impact on the offspring's cardiometabolic health with dysregulation of metabolism including glucose/insulin homoeostasis, and development of hypertension and vascular dysfunction. Potential mechanisms include effects on the development and function of adipose tissue, pancreas, muscle, liver, the vasculature and the brain. Further studies are required to elucidate the mechanisms underpinning the programming of disease risk in the offspring as a consequence of maternal obesity. The ultimate aim is to identify potential targets, which may be amenable to prevention or early intervention in order to improve the health of this and future generations.

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Section: Programming Of Obesity and Body Compositionmentioning

confidence: 99%

Section: Glucose/insulin Homoeostasis and Pancreatic Functionmentioning

confidence: 99%

Section: Programming Of Blood Pressure and Vascular Functionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of maternal obesity on offspring obesity and cardiometabolic disease risk

Drake¹,

Reynolds²

2010

Reproduction

442

308

View full text Add to dashboard Cite

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“…Several obesogenic models, primarily in the rodent, show a relatively common phenotype of metabolic disorders in offspring, although the magnitude of effects differs with the timing of the nutritional challenge and diet composition [84] . A maternal cafeteria or high fat diet has been shown to induce obesity, insulin and leptin resistance [58,85,86] , hypertension [87][88][89] , hepatic steatosis and non-alcoholic fatty liver disease in offspring [90][91][92] . Even mild maternal overnutrition has been shown to induce increased adiposity, glucose intolerance and altered brain appetite regulators in offspring [93] .…”

Section: Maternal Obesitymentioning

confidence: 99%

Developmental programming of the metabolic syndrome - critical windows for intervention

Vickers

2011

WJG

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Metabolic disease results from a complex interaction of many factors, including genetic, physiological, behavioral and environmental influences. The recent rate at which these diseases have increased suggests that environmental and behavioral influences, rather than genetic causes, are fuelling the present epidemic. In this context, the developmental origins of health and disease hypothesis has highlighted the link between the periconceptual, fetal and early infant phases of life and the subsequent development of adult obesity and the metabolic syndrome. Although the mechanisms are yet to be fully elucidated, this programming was generally considered an irreversible change in developmental trajectory. Recent work in animal models suggests that developmental programming of metabolic disorders is potentially reversible by nutritional or targeted therapeutic interventions during the period of developmental plasticity. This review will discuss critical windows of developmental plasticity and possible avenues to ameliorate the development of postnatal metabolic disorders following an adverse early life environment.

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“…3,4 Animal models have identified the risk of hypertension, 5,6 vascular dysfunction, 7 cardiac hypertrophy, and contractile dysfunction 8,9 all to be influenced by maternal obesity during pregnancy. The molecular mechanisms underlying programmed pathologies are not known, but studies in inbred animal model systems again argue against a simple genetic basis.…”

Section: Introductionmentioning

confidence: 99%

Nutrition has a pervasive impact on cardiac microRNA expression in isogenic mice

et al. 2016

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The complex interaction between obesity, Western-style diets, and cardiovascular disease is of increasing interest, with a growing number of children being born to obese parents with poor lifestyle choices. These offspring have themselves an increased susceptibility to obesity and subsequent cardiovascular disease in adult life, which may be 'programmed' by their intrauterine environment. Cardiac microRNAs (miRNAs) are affected by multiple disease states, and have also been shown to be capable of exerting a hormone-like control on whole body metabolism. Here we sought to determine the effect of prenatal exposure to maternal obesity and/or postnatal exposure to a Western diet on miRNA expression in the heart. Unbiased small RNA sequencing was carried out on cardiac tissue from young adult mice born to lean or obese mothers; offspring were weaned onto either a low-fat control diet or a high-fat Western-style diet. We found 8 cardiac miRNAs that were significantly altered in response to maternal obesity, but only when the offspring were challenged postnatally with the Western diet. In contrast, postnatal exposure to the diet alone induced significant changes to the expression of a much larger number of miRNAs (33 in offspring of lean and 46 in offspring of obese). Many of the affected miRNAs have previously been implicated in various cardiac pathologies. The pervasive cardiac miRNA changes induced by a Western diet suggest that an individual's lifestyle choices outweigh the impact of any programming effects by maternal obesity on miRNA-related cardiac health.

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Intrauterine exposure to high saturated fat diet elevates risk of adult‐onset chronic diseases in C57BL/6 mice

Cited by 99 publications

References 43 publications

Impact of maternal obesity on offspring obesity and cardiometabolic disease risk

Impact of maternal obesity on offspring obesity and cardiometabolic disease risk

Developmental programming of the metabolic syndrome - critical windows for intervention

Nutrition has a pervasive impact on cardiac microRNA expression in isogenic mice

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