Intrauterine adhesion prevention after hysteroscopy: a systematic review and meta-analysis

Aspirin inhibits endometrial fibrosis by suppressing the�TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions

“…Intrauterine adhesions (IUAs) were first defined by Joseph Asherman in 1948, and their presence is also known as Asherman syndrome (1). Endometrial fibrosis is caused by various factors, such as trauma and infection, and it results in impaired endometrial function, endometrial adhesion, uterine cavity degeneration and progression to an IUA (2,3). The primary clinical symptoms of IUAs include decreased menstruation, amenorrhea, repeated spontaneous abortion and infertility (3), which have adverse effects on the physical and mental health of the patients.…”

Efficacy of freeze-dried amnion graft following hysteroscopic adhesiolysis of severe intrauterine adhesions

“…Such approaches include placement of an intrauterine device, intrauterine stents, or a balloon in the uterine cavity after surgery; use of a gel containing anti-adhesion substances, such as hyaluronic acid; and use of estrogen therapy during the postoperative period to stimulate endometrial regeneration. [5][6][7][8][9] Amnion grafting has also been used with some success; [10][11][12] however, grafting fresh amnion tissue can be a challenge owing to the risk of transmitting infection and uncertainty regarding availability. Freeze-dried amnion graft was, therefore, been tested in a preliminary study, which reported efficacy approaching that of fresh amnion graft.…”

Decreased CXCL5 expression associated with intrauterine adhesions in a rat model and human endometrial tissues

“…This chemical method is more controllable and easier to operate than the mechanical injury method, and therefore is suitable to be used as a relatively steady and reproducible in ammation-induced animal model of IUA. Although in ammation at the site of endometrial injury is widely considered as the leading cause of IUA [1][2][3], other factors such as mechanical damage may also lead to IUA and even have been used to make IUA model in animals [28]. To this end, it is necessary to establish a shamoperated group to exclude mechanical damage, including the effects of surgical procedures and injection process on the IUA model rats and thus to con rm that the pathological characteristics in IUA group are only caused by a given concentration of toxic agents.…”

“…Intrauterine adhesion (IUA), also known as Asherman syndrome, is characterized by adhesions and brosis in endometrium within the uterus and/or cervix, and partial or complete obliteration of the uterine cavity [1,2]P. IUA occurs most commonly and frequently after trauma or infection, such as a simple operation on the uterus like a cesarean section, especially during the postpartum period with low estradiol levels [3].…”