Efficacy of freeze-dried amnion graft following hysteroscopic adhesiolysis of severe intrauterine adhesions

Abstract

Use of freeze-dried amnion graft was effective in reducing IUA reformation and improving menstruation (according to pictorial blood-loss assessment chart) following hysteroscopic adhesiolysis of severe IUAs. ClinicalTrials.gov: (NCT02496052).

Meta‐analysis of the use of amniotic membrane to prevent recurrence of intrauterine adhesion after hysteroscopic adhesiolysis

“…2), amniotic membrane treatment increased the menstrual blood volume after hysteroscopic adhesiolysis. 15,16,18 No statistically significant between-group differences were found for either measure. 15,16,18 No statistically significant between-group differences were found for either measure.…”

“…No statistically significant differences in baseline data between the treatment and the control groups were reported in three studies [16][17][18] However, the fourth study showed a statistically significant difference in the etiology of intrauterine adhesions. 15,16,18 One study used a randomized controlled design but did not use allocation concealment or masking methods. Three studies adopted randomized, controlled, and masked methods, which are associated with high literature quality.…”

“…15 The quality evaluation is shown in Figure S1. 17 Three studies reported on AFS scoring [16][17][18] ; however, two of these studies 16,17 could not be analyzed because the data did not have a normal distribution and, consequently, had no standard deviation available. 15,16,18 One study used a randomized controlled design but did not use allocation concealment or masking methods.…”

“…1). [16][17][18] When compared with before hysteroscopic adhesiolysis (Fig. [16][17][18] When compared with before hysteroscopic adhesiolysis (Fig.…”

“…Three of the four studies included in the current meta-analysis adopted the 1988 AFS classification for intrauterine adhesion [16][17][18] and quantified menstruation on the basis of the WHO pictorial blood loss assessment chart. Three of the four studies included in the current meta-analysis adopted the 1988 AFS classification for intrauterine adhesion [16][17][18] and quantified menstruation on the basis of the WHO pictorial blood loss assessment chart.…”