Intraurethral fluorouracil and lidocaine for intraurethral condyloma acuminata

Gammon, David C.; Reed, Keith A.; Patel, Mausaum; Balaji, K.C.

doi:10.2146/ajhp070504

Cited by 13 publications

(4 citation statements)

References 19 publications

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“…Furthermore, other adverse events such as hematuria and stricture rarely occurred with 5-FU instillation. Previous studies have reported various regimens of 5-FU instillation, such as dose, retention time, dosage frequency, and the number of cycles [5][6][7][8]. In the current study, 10 ml of 5% 5-FU cream was administered to the urethra for a total of twice biweekly intervals.…”

Section: Discussionmentioning

confidence: 94%

“…A novel device, an endoscopic hemostatic applicator, was used for even instillation from the prostatic urethra to the urethral meatus to prevent the recurrence of CA. In previous studies, the instillation of 5-FU was performed using a lidocaine syringe [7,8]. However, we believed that the lidocaine syringe is inadequate to evenly distribute 5-FU in the entire urethra.…”

Section: Discussionmentioning

confidence: 99%

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Intraurethral Instillation of 5-fluorouracil with Suprapubic Cystostomy for Intraurethral Condyloma Acuminatum

Kim

2023

Urogenit Tract Infect

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Condyloma acuminatum is a common sexually transmitted disease caused by the human papillomavirus and with a high recurrence rate in the urethra. We report the intraurethral instillation of 5-fluorouracil cream for intraurethral condyloma acuminatum with suprapubic cystostomy after transurethral surgery. A 64-year-old man had gross hematuria for several days. At cystourethroscopy, multiple papillary mass lesions were identified on the entire urethra. Transurethral resection of the urethral masses confirmed the diagnosis of condyloma acuminatum. However, recurrent multiple warts were identified on the whole urethra. After re-surgery, intraurethral instillation of 5-fluorouracil cream with suprapubic cystostomy was achieved to prevent a recurrence. After one year of 5-fluorouracil instillation, there was no recurrence of intraurethral condyloma acuminatum.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Intraurethral Instillation of 5-fluorouracil with Suprapubic Cystostomy for Intraurethral Condyloma Acuminatum

Kim

2023

Urogenit Tract Infect

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“…Consequently, it is considered wise neither to obtain specimens for pathologic analysis nor to perform virus typing in a routine fashion, as recommended by the most important guidelines. 20…”

Section: Discussionmentioning

confidence: 99%

Urethral condylomas in men: experience in 123 patients without previous treatment

Vives

Vázquez²,

Rajmil

et al. 2015

Int J STD AIDS

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The most common sexually transmitted infection (STI) is infection by human papillomavirus. There are more than 100 types of human papillomavirus, and over 30 of them involve the genital area. Urethral involvement is uncommon and usually limited to the distal 3 cm of the meatus. There are various treatments for urethral condylomas; as a rule, they are limited by a difficult approach, by recurrences, and by potential complications, the most significant of which is urethral stenosis. The purpose of the treatments is to remove the warts and induce lesion-free periods. Such treatments do not eliminate the infection nor do they prevent continued transmission of the virus. We retrospectively evaluated 123 patients diagnosed and treated for condylomas in the genital area at our Institution between April 2009 and April 2012. The patients' mean age was 28.7 years (range 19-51). Of the 123 patients included, 48 (39%) had a history of previous STIs, most frequently gonococcal urethritis. Three of them had a urethral malformation in the form of hypospadias, and another three reported a previous urologic manipulation (catheterisation). Meatal/urethral condylomas are rare, cryotherapy is simple, easy to apply, and has a very low risk of complications in patients with externally accessible warts.

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“…Surgical excision and laser therapy pose a significant risk of stricture. Although urethral instillation of fluorouracil injection has been reported to be effective for intraurethral condylomata acuminata, 9 it has not been established definitively.…”

Section: Discussionmentioning

confidence: 99%

Intraurethral condylomata acuminata associated with genital piercings

Takahashi

Hirano

Kawamura

et al. 2013

International Journal of STD & AIDS

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A 33-year-old man was referred to our institution with papillary masses at the urethral meatus and difficulty urinating. Genital examination showed two piercings on the frenulum, which were penetrating the external urethra. Endoscopic examination revealed papillary tumours over the entire circumference of the penile urethra and the piercing site. The tumours were resected transurethrally. Microscopic examination revealed condylomata acuminata. Human papillomavirus types 6 and 66 were detected in the lesions. Retrograde urethral viral infection is rare because of the protection provided by the mucosal immune system. Genital piercing may have facilitated spread of the human papillomavirus into the urethra.

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Intraurethral fluorouracil and lidocaine for intraurethral condyloma acuminata

Abstract: Urethral instillation via urethral syringe of fluorouracil injection mixed with lidocaine gel reduced the size and number of a man's intraurethral condyloma acuminata, allowed cystourethroscopy, and eliminated hematuria. There was no new growth of condyloma acuminata after six months.

Cited by 13 publications

References 19 publications

Intraurethral Instillation of 5-fluorouracil with Suprapubic Cystostomy for Intraurethral Condyloma Acuminatum

Intraurethral Instillation of 5-fluorouracil with Suprapubic Cystostomy for Intraurethral Condyloma Acuminatum

Urethral condylomas in men: experience in 123 patients without previous treatment

Intraurethral condylomata acuminata associated with genital piercings

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