Intratympanic gentamicin in Menière's disease: The impact on tinnitus: Gentamicina intratimpánica en la enfermedad de Meniére: Su efecto en el acúfeno

Abstract

Intratympanic administration of gentamicin for the treatment of intractable Menière's disease can achieve relief of vertigo. However, the effect of gentamicin on tinnitus has been less well identified. and conflicting results have been reported. Intratympanic gentamicin therapy was given to 25 patients with Menière's disease for the control of vertigo, and the effect of the therapy on tinnitus was evaluated by a 10-point scale and a modified tinnitus questionnaire. It was found that the tinnitus decreased in four patients (16%) and disappeared in three patients (12%) at follow-up. The effect of gentamicin on tinnitus presented intersubject variability, and no correlation was found between the amount of gentamicin injected and its effect on tinnitus.

Intratympanic Gentamicin for Intractable Ménière's Disease – A Review and Analysis of Audiovestibular Impact

“…Yetiser et al, who gave 3 gentamicin injections for the 3 consecutive days, followed-up their patients after treatment with caloric testing for 6 months and found a constant increase in the number of patients having caloric weakness or inexcitability up to 2 weeks. 20 Murofushi et al, who gave multiple injections, concluded that the patients with abolished caloric response had chronic vestibular insufficiency that was not less than those after vestibular neurectomy or surgical labyrinthectomy. 6 Therefore, the aim of the gentamicin therapy should be the control of the vertigo with preservation of the caloric response.…”