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“…Hepatocellular carcinoma, one of the malignant cancers with high heterogeneity, is frequently diagnosed in its middle and advanced stages ( Friemel et al, 2015 ; Buczak et al, 2018 ). Surgical resection remains the most crucial technique for HCC treatment; however, its therapeutic effects are always unsatisfactory ( Abe et al, 2017 ; Deng et al, 2020 ).…”
Section: Discussionmentioning
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“…Hepatocellular carcinoma, one of the malignant cancers with high heterogeneity, is frequently diagnosed in its middle and advanced stages ( Friemel et al, 2015 ; Buczak et al, 2018 ). Surgical resection remains the most crucial technique for HCC treatment; however, its therapeutic effects are always unsatisfactory ( Abe et al, 2017 ; Deng et al, 2020 ).…”
Section: Discussionmentioning
“…Resistant subpopulations which are often poorly differentiated tend to escape from chemotherapies and overgrow due to a forced selection in exposure to chemotherapy. 6 Our preliminary RNA-sequencing (RNA-Seq) study revealed that another ABC member, TAP1 (ABCB2, ABC subfamily B member) highly expressed in both Huh-7-trans and Huh-7-DN subpopulations.…”
Section: Introductionmentioning
“…Liver cancer is listed as the fourth common malignancy and the second major cause of death 1,2 . Treatment strategies for liver cancer are limited, especially for the patients with distant metastasis and recurrence after surgery 3,4 .…”
Section: Introductionmentioning