Intrathyroidal persistence of human parvovirus B19 DNA in a patient with Hashimoto's thyroiditis

Mori, Keiichiro; Munakata, Yasuhiko; Saitô, Takako; Tani, Junichi; Nakagawa, Yasuaki; Hoshikawa, Saeko; Ozaki, Hiroshi; Ito, Sadayoshi; Yoshida, Katsumi

doi:10.1016/j.jinf.2007.05.173

Cited by 43 publications

(36 citation statements)

References 18 publications

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“…Additional avenues to the breaking of tolerance, probably involving cross reactivity of antibody due to molecular mimicry, have also been suggested. These include responses to Candida albicans ( Vojdani et al, 1996), Bifidobacterium and Lactobacillis species ( Kiseleva et al, 2011), Helicobacter pylori strains expressing CagA ( Figura et al, 1999), Yersinia enterocolitica , Clostridium botulinum neurotoxin A ( Gregoric et al, 2011), HCV (Tomer and Villanueva, 2004), and human parvovirus B19 (Mori et al, 2007). Recently Gammazza et al (2014) have identified heat shock protein Hsp60 as another potential mimic which would add stress to the list of factors potentially involved.…”

Section: Introductionmentioning

confidence: 99%

Thyroid autoimmunity as a window to autoimmunity: An explanation for sex differences in the prevalence of thyroid autoimmunity

Merrill

2015

Journal of Theoretical Biology

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Section: Introductionmentioning

confidence: 99%

Thyroid autoimmunity as a window to autoimmunity: An explanation for sex differences in the prevalence of thyroid autoimmunity

Merrill

2015

Journal of Theoretical Biology

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“…There have been 3 case studies and a fourth group study linking thyroid diseases with B19 [33][34][35][36]. Our laboratory and others have shown that B19 infects the thyroid [37][38][39].…”

Section: Infection Of Other Organs and Its Resulting Effect On Brainmentioning

confidence: 99%

How Do Viruses Really Cause Neuropathology?: Is There More to the Story

Hobbs¹,

Waseem²

2016

J Neuroinfect Dis

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Our work has focused over the years on Primate Erythroparvovirus 1 [more commonly known as parvovirus B19 (B19)]. B19 is a human pathogen that is the causative agent of erythema infectiosum, the common rash disease of childhood. In addition to several other human diseases, B19 has also been associated with multiple brain diseases. Those brain diseases include, but are not limited to, encephalitis, encephalopathy, meningitis, meningoencephalitis, ataxia, seizures, and stroke. To date, the association has grown, but causation has not been determined. Several possible mechanisms of pathogenesis including direct infection, indirect/epigenetic, reactivation, and autoimmune/ inflammatory cytotoxicity, as well as effects due to infection of other organs have been suggested. We will also offer other hypotheses.

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“…Çalışmamızda ELISA yöntemi ile Anti-Parvovirus B19 IgM ve IgG antikorları araştırılmış ancak Parvovirus B19 DNA PCR yöntemiyle çalışılamamıştır. Wang ve Mori [22][23] yaptıkları çalışmalarında hashimato tiroiditli dokuda Parvovirüs B19 nükleik asidi ve viral proteinleri göstermişlerdir. Leihman ve arkadaşları [19] Hashimato tiroiditli hastalarda viral DNA, VP1,VP2 ve NS1 proteinlerine karşı antikor arayarak Parvovirüs ile ilişkiyi araştırmışlar ve antikor dü-zeylerinde farklılık bulamamışlardır.…”

Section: Discussionunclassified

The Evaluation of the Relationship Between Parvovirus B19 and Hashimato Thyroiditis

Ece¹

2015

Ann Clin Anal Med

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ÖzetAmaç: Kronik lenfositik tiroidit veya otoimmun tiroidit olarak da bilinen Hashimoto tiroiditinde (HT) tiroid follikullerinin lenfosit ve plazma hücreleri ile tutulumuyla tiroid dokusunda hasar ve atrofi meydana gelmektedir. Hashimoto tiroiditi ile bazı HLA antijen gruplarının birlikteliğinin bildirilmesi bu hastalığın genetik bir yatkınlık zemininde geliştiğini düşündürmektedir. Parvovirüs B19 yaygın görülen ve insanlarda hastalık yapabilen tek zincirli bir DNA virüsüdür. Parvovirüs B 19 enfeksiyonunun otoimmün hastalıkların etiyolojisi veya tetiklenmesinden sorumlu olabileceği düşünülmektedir. Çalışmamızda Hashimato tiroiditi tanısı alan hastaların Parvovirüs B19 ile ilişkisinin araştı-rılması amaçlandı. Gereç ve Yöntem: Çalısmaya hastanemizin dahiliye polikliniğine başvuran ve Hashimato tiroiditi tanısı almış 50 hasta ile kontrol grubu olarak 30 sağlıklı gönüllü alındı. Kontrol ve hasta grubunda Parvovirus B19 IgM ve IgG EIA (Virion/Serion,5 Almanya) yöntemi ile çalışıldı. İstatistiksel sonuçlar İzmir Üniversitesi Tıp Fakültesi Biyoistatistik AD tarafından ki-kare testi ile değerlendirildi. p< 0.05 anlamlı olarak kabul edildi. Bulgular: Çalış-maya dahil edilen toplam 50 Hashimato tiroiditi hastasının üçünde (%6) Parvovirus B19 IgM pozitifliği 36 (%72) hastada ise IgG seropozitifliği saptandı. Kontrol grubunda ise dört hastada IgM (%13.3) pozitifliği, 15 hastada (%50) IgG seropozitifliği saptandı. İstatiksel olarak IgM değerleri açısından hasta ve kontrol grubunda fark bulunmadı (p>0.05). Hasta grubundaki IgG değer-leri ise istatiksel olarak anlamlı yüksek bulundu (p<0.05). Tartışma: Viral enfeksiyonlar birçok otoimmun hastalığın fizyopatolojisinde etkili olabilir. Çalış-mamızda Hashimato tiroiditi olan hastalarda kontrol grubuna göre Parvovirüs B19 IgG seropozitifliği daha yüksek bulundu (p<0.05). Bu sonucun önem-li olduğu ve bu konuda daha fazla hasta sayılarını içeren çalışmalara ihtiyaç olduğu düşüncesindeyiz. Anahtar KelimelerHashimato Tiroditi; Parvovirus B19; Otoimmun Antikor Abstract Aim: Hashimato thyroiditis also known as chronic lymphocytic thyroiditis or autoimmune thyroiditis is characterized by lymphocyte and plasma cell infiltration of thyroid follicles causing destruction and atrophy in thyroid tissue. Reports on coexistence of several HLA antigen types in Hashimoto thyroiditis may indicate genetic predisposition. Parvovirus B19 is a prevalent and single stranded DNA virus that can cause disease in humans. Parvovirus B 19 infection may be responsible for autoimmune disorders or trigger them. The aim of our study was to evaluate the relationship between Parvovirus B19 and Hashimato thyroiditis. Material and Method: Fifity patients with Hashimato thyroiditis that were admitted to our Internal Medicine outpatient clinic and thirty healthy subjects were included in this study. Parvovirus B19 IgM and IgG were studied by EIA (Virion/Serion, Germany). Statistical analysis of the data was studied with chi-square test at Izmir University School of Medicine Department of Biostatistics . p< 0.05 was ac...

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Intrathyroidal persistence of human parvovirus B19 DNA in a patient with Hashimoto's thyroiditis

Cited by 43 publications

References 18 publications

Thyroid autoimmunity as a window to autoimmunity: An explanation for sex differences in the prevalence of thyroid autoimmunity

Thyroid autoimmunity as a window to autoimmunity: An explanation for sex differences in the prevalence of thyroid autoimmunity

How Do Viruses Really Cause Neuropathology?: Is There More to the Story

The Evaluation of the Relationship Between Parvovirus B19 and Hashimato Thyroiditis

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