Intrathoracic tumor of the chest wall: A case of Castleman’s disease mimicking myositis of the lower extremities

Tampakis, Athanasios; Tampaki, Ekaterini Christina; Daikeler, Thomas; Lardinois, Didier

doi:10.1007/s11748-016-0743-z

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…Despite the rarity of CD, we have accumulated a set of diverse cases that enabled a comprehensive review of the diagnosis and therapeutic options available for this disorder. Furthermore, this study demonstrates the significance of including CD in the differential diagnosis of other diseases because it continues to earn its reputation as a "clinical mimicker" and is often (especially with the UCD variant) misdiagnosed or undiagnosed (1,2,(36)(37)(38). After histopathological examination, which remains the only method of obtaining a certain diagnosis of this disease, we identified all three histological types of CD among our cases.…”

Section: Discussionmentioning

confidence: 71%

Clinicopathological comparison and therapeutic approach to Castleman disease—a case-based review

Wojtyś¹,

Piekarska²,

Kunc

et al. 2019

J Thorac Dis

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Castleman disease (CD) is a rare, B-cell lymphoproliferative disorder affecting lymph nodes and extranodal anatomical locations. Four types of clinical presentations can be distinguished after exclusion of mimics. The first division is into unicentric CD (UCD) and multicentric CD (MCD). MCD is classified further as HHV-8-negative (idiopathic), MCD associated with HHV-8 infection, and POEMS associated MCD. From the histological standpoint, UCD and MCD can be classified as hyaline-vascular (HV), plasma cell (PC), or mixed cellularity (MC) type, with a spectrum of histopathological manifestations. We present clinical and histopathological features and grading of 25 cases of CD classified according to CDCN histological criteria and according to this clinical algorithm, along with outcomes. Here we provide a fineresolution description of the histological features of CD. We review and discuss the current diagnostic algorithm, grading system, and recently recommended treatment options. In the presented group of 25 patients with CD there were 14 women and 11 men in the age range 15-79 years. UCD was identified in 15 patients and it was most often located in mediastinum. MCD most frequently occurred as generalized lymphadenopathy. The most common type of CD was HV. All patients with UCD underwent complete surgical resection with a positive outcome. Patients with MCD had diagnostic partial surgical excision of the lesions, later followed by different types of treatment (corticosteroids, chemotherapy, radiotherapy, immunomodulatory agents) or 'watch and wait'. In four cases CD was associated with other malignancies (laryngeal cancer, small lymphocytic lymphoma, gallbladder cancer with hepatic metastases, primary squamous cell lung cancer). The accuracy of histopathological examination is essential and re-evaluation has to be performed in case of relapse or unexpected course of CD. Treatment tailored to fit the disease type and severity should follow the novel recommendations, including anti-IL-6 treatment in the case of MCD.

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Section: Discussionmentioning

confidence: 71%

Clinicopathological comparison and therapeutic approach to Castleman disease—a case-based review

Wojtyś¹,

Piekarska²,

Kunc

et al. 2019

J Thorac Dis

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show abstract

“…CD is often overlooked as a possible diagnosis due to its low incidence rate. The possibility of CD should be considered following the identification of a homogeneous vascular mass (8). CD most commonly affects the mediastinum (63%), followed by the abdomen (11%), retroperitoneum (7%) and axilla (4%) (12).…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

“…The optimal therapy for unicentric CD is surgical resection, which is usually curative if the disease is amenable to complete resection (5). Surgical resection is a useful approach for the diagnosis and treatment of the disease (8).…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

“…Possible differential diagnosis based on the images were CD, primary mesenteric gastrointestinal stromal tumor or leiomyoma. At first, a diagnosis of CD was doubted as the tumor had calcification, exhibited a strong contrast in imaging, had an uniform edge and a relatively uniform inside on the abdominal CT scan; the tumor was generally isointense on T1 weighted images and hyperintense on T2 images (8). Surgical resection following embolization was suggested.…”

Section: Case Reportmentioning

confidence: 99%

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Surgical resection for pelvic retroperitoneal Castleman's disease: A case report and review literature

et al. 2021

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Castleman's disease (CD) is a rare atypical lymphoproliferation disorder first reported in 1954. Clinically, CD is classified as unicentric or multicentric CD based on anatomical distribution. Unicentric CD primarily affects the mediastinum, and rarely affects the retroperitoneal location. The standard treatment for unicentric CD is complete surgical resection; however, this can be complicated by a high degree of attachment with other organs or hypervascularity. Preoperative angiography and embolization of the arteries that feed the problematic mass can reduce intraoperative bleeding in cases of CD with hypervascularity. In the present case report, a 44-year-old man who was found to have a pelvic retroperitoneal mass with calcification based on abdominal imaging results is discussed. Due to the hypervascularity of the mass, preoperative embolization was performed. The mass was completely resected without any complications. Additionally, a review of the literature on pelvic CD and preoperative embolization of CD was performed to provide an up-to-date reference on the management and outcomes of patients with CD.

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Intrathoracic tumor of the chest wall: A case of Castleman’s disease mimicking myositis of the lower extremities

Cited by 2 publications

References 5 publications

Clinicopathological comparison and therapeutic approach to Castleman disease—a case-based review

Clinicopathological comparison and therapeutic approach to Castleman disease—a case-based review

Surgical resection for pelvic retroperitoneal Castleman's disease: A case report and review literature

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