Surgical resection for pelvic retroperitoneal Castleman's disease: A case report and review literature

Abstract

Castleman's disease (CD) is a rare atypical lymphoproliferation disorder first reported in 1954. Clinically, CD is classified as unicentric or multicentric CD based on anatomical distribution. Unicentric CD primarily affects the mediastinum, and rarely affects the retroperitoneal location. The standard treatment for unicentric CD is complete surgical resection; however, this can be complicated by a high degree of attachment with other organs or hypervascularity. Preoperative angiography and embolization of the arteries that feed the problematic mass can reduce intraoperative bleeding in cases of CD with hypervascularity. In the present case report, a 44-year-old man who was found to have a pelvic retroperitoneal mass with calcification based on abdominal imaging results is discussed. Due to the hypervascularity of the mass, preoperative embolization was performed. The mass was completely resected without any complications. Additionally, a review of the literature on pelvic CD and preoperative embolization of CD was performed to provide an up-to-date reference on the management and outcomes of patients with CD.

Castleman's disease in the pelvic retroperitoneum: A case report

“…Given their proximity to major vascular structures of the pelvis, surgeons were occasionally faced with a clinical situation in which a large-volume blood transfusion was necessary (8). Thus, certain surgeons used preoperative angiography and embolization of the feeding arteries to the tumor in order to prevent or limit intraoperative bleeding (9). The present study reported a rare case of UCD located in the pelvic retroperitoneum, which was completely resected by meticulous laparoscopic surgery with limited bleeding.…”

A Multifunctional Therapeutic Strategy Using P7C3 as A Countermeasure Against Bone Loss and Fragility in An Ovariectomized Rat Model of Postmenopausal Osteoporosis

“…Finally, our results also show significant upregulation of the key neurogenic factor neurexin‐1α, which influences synapse function and neuronal connectivity, [ 239,240 ] with major downregulation of SIRPα, expressed on myeloid cells and neurons. [ 241,242 ] Further, KLKB1, a blood coagulation factor, [ 243 ] was also significantly upregulated in P7C3 treated animals. Although their effect, in addition to the neurotrophin, TrkA is evidently significant in this study, it remains unclear how osteoneuronal activity contributed to the protection in bone loss, and maintenance in bone strength observed following OVX.…”

Castleman disease: Report of a case and review of literature on role of preoperative embolization

“…Outcomes in the reported cases, such as estimated blood loss, effect on tumor size, time interval between angioembolization and surgery, postoperative complications, and use of a surgical drain have been reported. Table 1 lists the literature review on the role of preoperative angioembolization in CD [16] , [17] , [18] , [19] , [20] , [21] .…”