Intrathoracic Extravasation of Antineoplastic Agents

Bozkurt, Ahmet; Uzel, Burak; Akman, Canan; Özgüroǧlu, Mustafa; Mandel, Nil Molınas

doi:10.1097/00000421-200304000-00003

Cited by 45 publications

(25 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Depending on the site of extravasation, alteration in limb function and even mediastinal damage may occur. 70 The degree of tissue injury may be severe enough to necessitate surgical debridement.…”

Section: Extravasation Injuriesmentioning

confidence: 99%

Vascular Access in Oncology Patients

Gallieni

Pittiruti

Biffi

2008

CA: A Cancer Journal for Clinicians

245

164

View full text Add to dashboard Cite

Adequate vascular access is of paramount importance in oncology patients. It is important in the initial phase of surgical treatment or chemotherapy, as well as in the chronic management of advanced cancer and in the palliative care setting. We present an overview of the available vascular access devices and of the most relevant issues regarding insertion and management of vascular access. Particular emphasis is given to the use of ultrasound guidance as the preferred technique of insertion, which has dramatically decreased insertion-related complications. Vascular access management has considerably improved after the publication of effective guidelines for the appropriate nursing of the vascular device, which has reduced the risk of late complications, such as catheter-related bloodstream infection. However, many areas of clinical practice are still lacking an evidence-based background, such as the choice of the most appropriate vascular access device in each clinical situation, as well as prevention and treatment of thrombosis. We suggest an approach to the choice of the most appropriate vascular access device for the oncology patient, based on the literature available to date. (CA Cancer J Clin 2008;58:323-346.)

show abstract

Section: Extravasation Injuriesmentioning

confidence: 99%

Vascular Access in Oncology Patients

Gallieni

Pittiruti

Biffi

2008

CA: A Cancer Journal for Clinicians

245

164

View full text Add to dashboard Cite

show abstract

“…3,27,29,73,74 However, it has been estimated that surgery is required for up to one-third of cases. 29,40,75 Therefore, timely surgical consultation is important to minimize adverse outcomes when extravasation of nonanthracycline vesicants occurs (anthracycline extravasations are immediately treated with Totect ® ).…”

Section: Surgical Interventionmentioning

confidence: 99%

Infiltration and Extravasation

Doellman

Hadaway²,

Bowe-Geddes³

et al. 2009

Journal of Infusion Nursing

176

View full text Add to dashboard Cite

Infiltration and extravasation are risks of intravenous administration therapy involving unintended leakage of solution into the surrounding tissue. Consequences range from local irritation to amputation. While immediate action using appropriate measures (ie, dilution, extraction, antidotes, and supportive treatments) can decrease the need for surgical intervention, many injuries may be prevented by following established policy and procedures. However, timely surgical intervention, when necessary, can prevent more serious adverse outcomes. Clinicians should be prepared to act promptly when an event occurs. Thorough incident documentation helps determine whether infusion care meets the standard of practice and is a keystone to medicolegal defense.

show abstract

“…In our single center experience, over 800 courses of trabectedin have been administered via outpatient 24-hour infusion through CVADs, suggesting that extravasation requiring surgical intervention is an uncommon, but serious, risk of this agent. 17 While the use of central venous ports and other preventive measures have decreased the incidence of chemotherapy extravasation, the problem is recalcitrant. Older approaches tended to favor early surgical intervention.…”

Section: Journal Of Clinical Oncologymentioning

confidence: 99%