Intrathecal Clonidine as a Sole Analgesic for Pain Relief after Cesarean Section

Filos, Kriton S.; Goudas, Leonidas C.; Patroni, Ourania; Polyzou, V.

doi:10.1097/00000542-199208000-00008

Cited by 131 publications

(69 citation statements)

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“…VAS scores were significantly lesser with combination (BC-150<BC-75< B). Our study results were similar to Baker [19] , Strebel et al [20] , Grandhe [15] , Sethi et al [1] , Filos KS (1994) [21] , Mercier F J (1998) [22] and Chiari et al (1999) [23] .…”

Section: Discussionsupporting

confidence: 91%

ntrathecal Hyperbaric Bupivacaine with Two Different Doses of Clonidine in Lower Limb Orthopaedic Surgery: A Comparative Study

Ingley¹

2017

jmscr

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Introduction: Spinal anaesthesia has long been known to be of benefit to patients undergoing major orthopaedic procedure. Numerous studies have investigated the effects of intrathecal clonidine co B). Total duration of analgesia and time to 2-segment regression were significantly longer (BC-150 > BC-75 > B). The response was dose dependant. No patients required supplemental analgesia intra-operatively. Onset of motor block was less in BC-75. Duration was significantly higher with combinations (BC-150 > BC-75 > B). The response was again dose dependant. Post-operative analgesia was also significantly longer (BC-150 > BC-75 > B). Minor haemodynamic changes were seen in all three groups. Few complications were reported with BC-150. Conclusion: Small doses of clonidine (≤150 IntroductionSpinal anaesthesia is a simple technique. It provides a deep and fast surgical block through the injection of small doses of local anesthetic solution into the subarachnoid space. Spinal

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Section: Discussionsupporting

confidence: 91%

ntrathecal Hyperbaric Bupivacaine with Two Different Doses of Clonidine in Lower Limb Orthopaedic Surgery: A Comparative Study

Ingley¹

2017

jmscr

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“…Clonidine also exerts vasoconstricting effect on smooth muscles, which results in a decreased absorption of the local anesthetic agent and eventually prolongs the duration of analgesia. 12 In the present study, onset of sensory and motor blockade was accelerated with epidural fentanyl when compared to epidural clonidine. Time to attain maximum sensory level of T6-7 was also less in group RF when compared to group RC.…”

mentioning

confidence: 43%

Clonidine versus fentanyl as adjuvant to 0.75% ropivacaine for epidural anesthesia for lower limb surgeries: a comparative evaluation

Agarwal

Gupta

et al. 2016

Int J Res Med Sci

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“…10 Therefore, hemodynamic stability in our study can be attributed to a low dose of clonidine. Sedation, a central effect of α-2 adrenergigcs, may occur after either systemic, epidural or intrathecal administration of clonidine, 22,23 notably in the dose range of 150 to 450 µg. 11 However, in our study sedation is not observed in any of the patients in BC group, which also could be explained by the use of a low dose of intrathecal clonidine.…”

Section: Discussionmentioning

confidence: 99%

Intrathecal clonidine added to small-dose bupivacaine prolongs

Gecaj-Gashi

Terziqi

Pervorfi

et al. 2013

CUAJ

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Introduction: The aim of this prospective, double-blinded study was to investigate the effects of clonidine in co-administration with bupivacaine during spinal anesthesia, regarding the onset and regression of motor and sensory block, postoperative analgesia and possible side effects. Methods: We randomly selected 66 male patients (age 35 to 70), from the American Society of Anesthesiologists (ASA) class I-II; these patients were scheduled for transurethral surgical procedures. These patients were randomly allocated into two groups of 33 patients each: group B (bupivacaine) only received 0.5% isobaric bupivacaine 7.5 mg intrathecally and group BC (bupivacaine + clonidine) received bupivacaine 7.5 mg and clonidine 25 µg intrathecally. We performed the spinal anesthesia at a level of L3-L4 with a 25-gauge needle. We assessed the sensory block with a pinprick, the motor block using the Bromage scale, analgesia with the visual analog scale and sedation with the modified Wilson scale. We also recorded the hemodynamic and respiratory parameters. Results: The groups were demographically similar. The mean time of achievement of motor block (Bromage 3) and sensory block at level T9 was significantly shorter in the BC group compared with B group (p = 0.002, p = 0.000, respeectively). The motor block regression time was not significantly different between the two groups (p = 0.237). The postoperative analgesia requirement was significantly longer in group BC compared with group B (p = 0.000). No neurological deficit, sedation or other significant adverse effects were recorded. Conclusion: The intrathecal application of clonidine in combination with bupivacaine improves the duration and quality of spinal anesthesia; it also provides longer duration of postoperative analgesia, without significant side effects.

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Intrathecal Clonidine as a Sole Analgesic for Pain Relief after Cesarean Section

Cited by 131 publications

References 0 publications

ntrathecal Hyperbaric Bupivacaine with Two Different Doses of Clonidine in Lower Limb Orthopaedic Surgery: A Comparative Study

ntrathecal Hyperbaric Bupivacaine with Two Different Doses of Clonidine in Lower Limb Orthopaedic Surgery: A Comparative Study

Clonidine versus fentanyl as adjuvant to 0.75% ropivacaine for epidural anesthesia for lower limb surgeries: a comparative evaluation

Intrathecal clonidine added to small-dose bupivacaine prolongs

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