Intraspinal schwannoma and neurogenic bladder

Yang, Kaiyong; Ho, Ching-Sung; Tai, Po-An; Kung, Woon‐Man

doi:10.1308/rcsann.2018.0002

Cited by 7 publications

(6 citation statements)

References 5 publications

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“…Although our CNS ST‐deficient mouse model cannot differentiate the contribution by brain versus spinal cord, here we provided strong evidence emphasizing the critical involvement of spinal cord dysfunction in AD‐associated bladder disorders. Numerous studies have demonstrated the consequence of spinal cord disease 61–63 which leads to neurogenic bladder through myelin 63 or nerve damage 61,62 . Interestingly, both myelin disruption and neuronal deterioration were prominent in spinal cord tissue of ST‐deficient mouse model, strongly supporting the notion that ST loss‐induced spinal cord alterations contribute to neurogenic bladder in humans and mice.…”

Section: Discussionmentioning

confidence: 78%

“…Although our CNS ST-deficient mouse model cannot differentiate the contribution by brain versus spinal cord, here we provided strong evidence emphasizing the critical involvement of spinal cord dysfunction in AD-associated bladder disorders. Numerous studies have demonstrated the consequence of spinal cord disease [61][62][63] which leads to neurogenic bladder through myelin 63 or nerve damage. 61,62 F I G U R E 7 Graphic summary of the role of sulfatide (ST) in regulating spinal cord function in Alzheimer's disease (AD).…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have demonstrated the consequence of spinal cord disease [61][62][63] which leads to neurogenic bladder through myelin 63 or nerve damage. 61,62 F I G U R E 7 Graphic summary of the role of sulfatide (ST) in regulating spinal cord function in Alzheimer's disease (AD). Under normal condition, sufficient ST levels are critical for maintaining a stable myelin lipidome in order to facilitate physiological spinal cord activity in controlling peripheral organ functions.…”

Section: Discussionmentioning

confidence: 99%

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Central nervous system sulfatide deficiency as a causal factor for bladder disorder in Alzheimer's disease

He,

Qiu,

Pan

et al. 2023

Clinical & Translational Med

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Background Despite being a brain disorder, Alzheimer's disease (AD) is often accompanied by peripheral organ dysregulations (e.g., loss of bladder control in late‐stage AD), which highly rely on spinal cord coordination. However, the causal factor(s) for peripheral organ dysregulation in AD remain elusive. Methods The central nervous system (CNS) is enriched in lipids. We applied quantitative shotgun lipidomics to determine lipid profiles of human AD spinal cord tissues. Additionally, a CNS sulfatide (ST)‐deficient mouse model was used to study the lipidome, transcriptome and peripheral organ phenotypes of ST loss. Results We observed marked myelin lipid reduction in the spinal cord of AD subjects versus cognitively normal individuals. Among which, levels of ST, a myelin‐enriched lipid class, were strongly and negatively associated with the severity of AD. A CNS myelin‐specific ST‐deficient mouse model was used to further identify the causes and consequences of spinal cord lipidome changes. Interestingly, ST deficiency led to spinal cord lipidome and transcriptome profiles highly resembling those observed in AD, characterized by decline of multiple myelin‐enriched lipid classes and enhanced inflammatory responses, respectively. These changes significantly disrupted spinal cord function and led to substantial enlargement of urinary bladder in ST‐deficient mice. Conclusions Our study identified CNS ST deficiency as a causal factor for AD‐like lipid dysregulation, inflammation response and ultimately the development of bladder disorders. Targeting to maintain ST levels may serve as a promising strategy for the prevention and treatment of AD‐related peripheral disorders.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Central nervous system sulfatide deficiency as a causal factor for bladder disorder in Alzheimer's disease

He,

Qiu,

Pan

et al. 2023

Clinical & Translational Med

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“…Reportedly, 24% of all nerve sheath tumors in adults are schwannomas, which are the most frequent extramedullary, intradural spinal tumors [9]; intradural Schwannoma may rank up to a percentage of 83.67%. To our knowledge, the main symptoms caused by intradural extramedullary schwannoma are radiculopathy and neurogenic claudication, due to spinal cord compression with the growth of tumor [10,11]. What is more, it usually causes motor loss and worsening sensory, as well as back pain spreading out from the tumor level [12,13].…”

Section: Introductionmentioning

confidence: 99%

Clinical Effect of Laminectomy with Lateral Mass Screw Fixation in Treating Cervical Schwannoma: A Retrospective Study

Guo

Yang

et al. 2022

BioMed Research International

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Background. The objective of this study was to evaluate the clinical effectiveness and safety of laminectomy combined with lateral mass screw fixation in treating cervical intradural extramedullary schwannoma. Methods. We retrospectively collected and analyzed medical records of 38 patients who underwent resection of cervical intraspinal schwannoma between January 2012 and April 2019. Based on different surgical procedures, two groups were divided among all participants: laminectomy-only ( n = 21 ) and laminectomy with instrumented fixation ( n = 17 ); the minimum follow-up time was 1 year. The visual analogue scale (VAS) score and neck disability index (NDI) were utilized for pain assessment; the Japanese Orthopedic Association (JOA) score was carried out for the assessment of neurological impairment. Radiographic changes of Cobb angle were compared before and after the surgery. Results. Consequently, demographics were well matched in both groups, without any statistical difference ( P > 0.05 ). Compared with preoperation, both surgical procedures significantly improved VAS, NDI, and JOA scores ( P < 0.001 ), but no differences between them ( P > 0.05 ). In terms of postoperative spinal instability/deformity, laminectomy-only caused more events than instrumented fixation, which is statistically significant ( P < 0.001 ). Conclusions. In summary, laminectomy with lateral mass screw fixation is an effective and safe approach to treat cervical intraspinal schwannoma, which is likely to be a better choice than the laminectomy-only approach.

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“…Neurogenic claudication and radiculopathy are the 2 main symptoms of intradural extramedullary schwannomas, and occur due to spinal cord compression as the tumor grows [8,9], and usually cause worsening sensory and even motor loss, as well as the back pain resulting from tumor compression. The annual incidence of spinal schwannoma is relatively low, and patients with these tumors are generally in their 4 th or 5 th decades of life [10].…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Laminectomy with Instrumented Fixation in Treating Thoracolumbar Intradural Extramedullary Schwannomas: A Comparative Study

et al. 2020

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Departmental sources Background:This study investigated the clinical effect of laminectomy plus pedicle screw fixation in treating thoracolumbar intradural extramedullary schwannomas. Material/Methods:Between October 2011 and May 2017, 57 patients undergoing resection of thoracolumbar schwannomas were retrospectively identified and included in the study. Based on the surgical procedures used, all participants were assigned to either the laminectomy-only group (n=33) or the combination group (laminectomy plus pedicle screw fixation, n=24). All participants were followed up for over 2 years. In the laminectomy, the spinal process, vertebral laminae, and bilateral upper articular processes of the surgical segments were completely resected and the lower articular processes were reserved. For further analysis, we evaluated the pain levels using visual analogue scale (VAS) score. The assessment of neurological function was performed with Japanese Orthopaedic Association (JOA) score and Oswestry disability index (ODI). The comparisons of Cobb angle changes were carried out pre-surgery and post-surgery. Results:The demographic data were well matched between the laminectomy-only group and combination group, without significant differences (P>0.05). After surgery, both surgical procedures achieved significant improvement in VAS score, ODI, and JOA score (P<0.001), but no significant differences were found between these 2 surgical procedures (P>0.05). The postoperative change in Cobb angle indicated a significant difference in the laminectomy-only group, but not in the combination group (P<0.05). In addition, postoperative spinal instability/ deformity was found in the laminectomy-only group (P<0.05). Conclusions:In conclusion, the combination of laminectomy and pedicle screw fixation is a safe and effective surgical procedure when used to treat thoracolumbar schwannoma, and appears to be superior to the laminectomy-only procedure.

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Intraspinal schwannoma and neurogenic bladder

Cited by 7 publications

References 5 publications

Central nervous system sulfatide deficiency as a causal factor for bladder disorder in Alzheimer's disease

Central nervous system sulfatide deficiency as a causal factor for bladder disorder in Alzheimer's disease

Clinical Effect of Laminectomy with Lateral Mass Screw Fixation in Treating Cervical Schwannoma: A Retrospective Study

Clinical Efficacy of Laminectomy with Instrumented Fixation in Treating Thoracolumbar Intradural Extramedullary Schwannomas: A Comparative Study

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