Alzheimer's disease (AD) is a progressive neurogenerative disorder associated with age, marked by a gradual decline in memory, cognitive impairment, and behavioural changes. Among its key pathological traits is the presence of extracellular neuritic plaques enriched in β-amyloid coupled with a decline in neuronal synapses and an accumulation of lipid granules.Within the brain, myelinating glial cells play a crucial role in providing electrical insulation and facilitating the swift propagation of action potential along neuronal axons. Approximately 80% of myelin's dry weight is composed of lipids, 1 which not only establish an optimal membrane fluidity but also provide the essential hydrophobic insulation required for effective action potential conduction. The composition of myelin lipids includes cholesterol, phospholipids, and sphingolipids. Among sphingolipids, sphingomyelin, ceramides, and sulfatide (ST) stand out as prominent enriched constituents within myelin membranes. 1 ST, predominantly located at the outer leaflet of the cell membrane across all eukaryotic cells, is associated with a variety of cellular processes including platelet aggregation, cell survival, immune responses, and host-pathogen interactions. 2 The enzyme cerebrosideThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.