Intraspecific variability of the Central American rattlesnake (Crotalus simus) venom and its usefulness to obtain a representative standard venom

Gómez, Aarón; Solano, Gabriela; Chang-Castillo, Arturo; Chacón, Danilo; Corrales, Greivin; Segura, Álvaro; Estrada, Ricardo; León, Guillermo

doi:10.1016/j.toxicon.2021.09.006

Cited by 2 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Creating an antivenom for each variation is not feasible [ 274 ]. Creating antivenoms primarily involves immunizing animals (such as horses, sheep, and cows) to produce antibodies that target and neutralize specific venom proteins [ 275 ]. These antivenoms are widely accepted and representative of the region’s snake population [ 275 ].…”

Section: Venom Constituents and Biomedical Applicationsmentioning

confidence: 99%

“…Creating antivenoms primarily involves immunizing animals (such as horses, sheep, and cows) to produce antibodies that target and neutralize specific venom proteins [ 275 ]. These antivenoms are widely accepted and representative of the region’s snake population [ 275 ]. Within antivenoms produced from the genus Crotalus, the concentration of crotoxin present in the venom administered to the animal can change the efficacy of the antivenom received [ 275 ].…”

Section: Venom Constituents and Biomedical Applicationsmentioning

confidence: 99%

“…These antivenoms are widely accepted and representative of the region’s snake population [ 275 ]. Within antivenoms produced from the genus Crotalus, the concentration of crotoxin present in the venom administered to the animal can change the efficacy of the antivenom received [ 275 ]. However, due to the high plasticity and variability of venom components, the potential impact of venom on biomedical and pharmaceutical discoveries is monumental [ 15 , 58 , 59 , 124 , 253 , 276 ], especially concerning minor components.…”

Section: Venom Constituents and Biomedical Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

A Review of Rattlesnake Venoms

Phan,

Deshwal,

McMahon

et al. 2023

Toxins

View full text Add to dashboard Cite

Venom components are invaluable in biomedical research owing to their specificity and potency. Many of these components exist in two genera of rattlesnakes, Crotalus and Sistrurus, with high toxicity and proteolytic activity variation. This review focuses on venom components within rattlesnakes, and offers a comparison and itemized list of factors dictating venom composition, as well as presenting their known characteristics, activities, and significant applications in biosciences. There are 64 families and subfamilies of proteins present in Crotalus and Sistrurus venom. Snake venom serine proteases (SVSP), snake venom metalloproteases (SVMP), and phospholipases A2 (PLA2) are the standard components in Crotalus and Sistrurus venom. Through this review, we highlight gaps in the knowledge of rattlesnake venom; there needs to be more information on the venom composition of three Crotalus species and one Sistrurus subspecies. We discuss the activity and importance of both major and minor components in biomedical research and drug development.

show abstract

Section: Venom Constituents and Biomedical Applicationsmentioning

confidence: 99%