Intraspecies and interspecies variations in the substrate specificity of d-amino acid oxidase

Konno, Ryuichi; Uchiyama, Saburo; Yasumura, Yosihiro

doi:10.1016/0305-0491(82)90490-4

Cited by 17 publications

(12 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…L-Methionine may be incorporated into proteins. (12,32,(55)(56)(57)91).However, the reported relative oxidation rates of D-methionine by D-amino acid oxidase in kidney homogenates from man, monkeys, chickens, frogs, rats, and mice do not support this hypothesis. For example, the reported rate of oxidation of D-methionine by the oxidase in mouse kidneys is about one third to one half of corresponding rates for rats or man.…”

Section: Biological Utilization Of D-amino Acidscontrasting

confidence: 50%

Formation, Nutritional Value, and Safety of D-Amino Acids

Friedman

1991

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

31The extent of racemization of L-amino acid residues to D-isomers in food proteins increases with pH, time, and temperature. The nutritional utilization of different D-amino acids vary widely, both in animals and humans.In addition, some D-amino acids may be deleterious. For example, although D-phenylalanine is nutritionally available as a source of L-phenylalanine, high concentrations of D-tyrosine inhibit the growth of mice. The antimetabolic effect of D-tyrosine can be minimized by increasing the L-phenylalanine content of the diet. Similarly, L-cysteine has a sparing effect on L-methionine when fed to mice; however, D-cysteine does not. The wide variation in the utilization of D-amino acids is exemplified by the fact that D-lysine is not utilized as a source of L-lysine, whereas the utilization of D-methionine as a source of the L-isomer for growth is dose-dependent, reaching 7&% of the value obtained with L-methionine. Both D-serine and the mixture of L-L and L-D isomers of lysinoalanine induce histological changes in the rat kidneys.D-tyrosine, D-serine, and lysinoalanine are produced in significant amounts under the influence of even short periods of alkaline treatment. Unresolved is whether the biological effects of D-amino acids vary, depending on whether they are consumed in the free state or as part of a food protein. Possible, metabolic interaction, antagonism, or synergism among D-amino acids jn vivo also merits further study. The described results with mice complement related studies with other species and contribute to the understanding of nutritional and toxi col ogi ca 1 consequences of i ngesti ng D-ami no acids.Such an understanding will make it possible to devise food processing conditions to minimize or prevent the formation of undesirable D-amino acids in food proteins and to prepare better and safer foods.

show abstract

Section: Biological Utilization Of D-amino Acidscontrasting

confidence: 50%

Formation, Nutritional Value, and Safety of D-Amino Acids

Friedman

1991

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

show abstract

“…This keto acid can then be converted to L-valine by the ubiquitous enzyme 2-oxoglutarate aminotransferase. D-amino acid oxidase has been found in common carp Cyprinus carpio L., dace Leuciscus leuciscus (L.), crucian carp Carassius carassius (L.), rainbow trout and the electric ray Torpedo marmorata Risso (Konno & Yasumura, 1981;Konno et al, 1982). Epithelial cells have significant roles to play in in vitro research of fish biology primarily since they are the dominant cell type in surface tissues that interact with the external environment and consequently those cells most affected by, or adapted to, changes in environmental conditions.…”

Section: Discussionmentioning

confidence: 99%

A dual enzyme method for the establishment of long‐ and medium‐term primary cultures of epithelial and fibroblastic cells from Atlantic salmon gills

Bütler

Nowak

2004

Journal of Fish Biology

View full text Add to dashboard Cite

A dual enzyme disaggregation method using collagenase and then trypsin was developed that allowed the reproducible initiation of primary cultures from Atlantic salmon Salmo salar gills. Cultures had both epithelial and fibroblast morphology and persisted for an average of 20 passages. Growth was dependent upon a minimum concentration of 5% foetal calf serum (FCS) for fibroblasts and 10% FCS for epithelial cells. Growth was mostly independent of substrate, although epithelial cells showed increased growth on type I collagen gels. Matrigel TM cell culture substrate produced reduced growth of fibroblasts and did not benefit epithelial cell growth. Epithelial cells reacted with monoclonal antibodies (MAbs) against mammalian cytokeratins, and fibroblast cells reacted with MAbs against mammalian fibronectin and type I collagen. The method also produced two long-term cultures: one epithelial and one fibroblast that have been designated RGE-2 and RGF respectively. # 2004 The Fisheries Society of the British Isles

show abstract

“…While examining the DAO activity in various animals, 28,29) Konno et al noticed that some mice in the population of a non-inbred ddY strain did not have DAO activity.…”

Section: A Mutant Mouse Strain Lacking Dao Ac-tivitymentioning

confidence: 99%