Intrapleural Insufflation of Dicetyl Phosphate to Promote Pleural Symphysis

Laforet, Eugene G.; Hering, Alexander C.

doi:10.1378/chest.44.5.505

Cited by 7 publications

(4 citation statements)

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“…Previous authors have reported that dogs undergoing gradual attenuation of a CEHPSS with a CB have a high rate of long‐term survival similar to dogs of the current study in which a non–cellulose based TFB was used . The lack of difference between long‐term outcome in dogs undergoing gradual attenuation of single CEHPSS with either a cellulose or non–cellulose‐based TFB could be attributed to diacetyl phosphate, a product used in the manufacturing process . The underlying mechanism of action for the inflammatory reaction after TFB implantation remains controversial and may be linked to the chemical composition of the TFB or to an ancillary product added during manufacturing .…”

Section: Discussionsupporting

confidence: 58%

“…The underlying mechanism of action for the inflammatory reaction after TFB implantation remains controversial and may be linked to the chemical composition of the TFB or to an ancillary product added during manufacturing . Diacetyl phosphate causes profound inflammatory reaction after implantation, providing evidence that, regardless of the composition of thin film used, a similar reaction can be expected because of the addition of this compound . Furthermore, on the basis of the results of the current study in which a non–cellulose‐based TFB was used, surgeons may not need to be concerned regarding the actual composition of TFB for gradual attenuation of CEPHSS.…”

Section: Discussionmentioning

confidence: 93%

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Long‐term clinical outcomes of dogs with single congenital extrahepatic portosystemic shunts attenuated with thin film banding or ameroid ring constrictors

et al. 2020

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Objective To compare long‐term clinical outcomes of dogs with single congenital extrahepatic portosystemic shunts (CEHPSS) treated with thin film banding (TFB) consisting of polyolefin fiber or ameroid ring constrictor (ARC) placement in dogs. Design Retrospective, two‐center clinical study. Animals Client‐owned dogs (n = 123) with single CEHPSS undergoing gradual attenuation via TFB (n = 85) or ARC (n = 38). Methods Medical records of dogs with CEHPSS were reviewed. Follow‐up data were collected from the referring veterinarian and/or owner via standardized questionnaire. Data were analyzed to compare short‐term mortality rate and long‐term outcome (>6 months). Results Dogs in the TFB group were older than dogs in the ARC group (median age, 19 vs 12 months, respectively; P = .01). There was no difference in survival to discharge between dogs in the TFB (81/85 [95.3%]) and ARC (37/38 [97.4%]; P > .99) groups. Preoperative levetiracetam was more frequently administered to dogs treated with TFB (64/85 [75.3%]) than to dogs treated with ARC (15/38 [39.5%;] P = .0002). Postoperative seizures were reported in 10 (8.1%) dogs; their prevalence did not differ between dogs treated with TFB (9/85 [10.6%]) and dogs treated with ARC (1/38 [2.6%]; P = .17). Median follow‐up time for dogs treated with TFB (58.0 months, range 8‐130) and ARC (63.3 months, range 7‐138; P = .24) did not differ. Conclusion Gradual attenuation of a single CEHPSS with either TFB or ARC resulted in similar long‐term clinical outcomes and low postoperative morbidity and mortality rates. Clinical significance Thin film banding (polyolefin fiber) offers an alternative leading to clinical outcomes similar to ARC in dogs with single CEHPSS.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 93%

Long‐term clinical outcomes of dogs with single congenital extrahepatic portosystemic shunts attenuated with thin film banding or ameroid ring constrictors

et al. 2020

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“…Dahl et al used concentration of dicetyl phosphate of 5 and 10% to induce consistent fibrosis in a rat model (Dahl et al,1960). An experimental study on dogs used 0.5 to 1 mg of pure dicetyl phosphate to induce pleurodesis (Laforet and Hering, 1963). It seems therefore unlikely that the low amount found in the TPFs could be judged significant and is more in the region of what could been be considered a contaminant of the TPF, based on the expert opinions of two of the authors (MJP, DJS).…”

Section: Discussionmentioning

confidence: 99%

“…Additives agents are combined to polymer films to improve their properties and prolong their life. A common agent added during processing of these TPFs is dicetyl phosphate as a stripping agent (Laforet and Hering, 1963;Yeager and Cowley, 1948). This agent has been shown to cause a marked inflammatory response in experimental animals and has been suggested to be responsible for inducing the inflammatory response seen with cellophane (Dahl et al, 1960;Smith et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

The chemical and ultra-structural analysis of thin plastic films used for surgical attenuation of portosystemic shunts in dogs and cats

Field

Scurr

Piggott

et al. 2019

Research in Veterinary Science

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The objective of the study was to (1) characterize and compare the chemical composition at the surface, subsurface and in the bulk of thin plastic films used for portosystemic shunt attenuation in their native state and after plasma exposure. (2) Assess the presence, concentration and location of irritant compounds (e.g dicetyl phosphate) within the films. Attenuated Total Reflectance Infrared Spectroscopy (ATR-IR), X-ray Photoelectron Spectroscopy (XPS) and dynamic Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) were used to analyze thirteen thin plastic films. Sample thickness was visualized and measured using Scanning Electron Microscopy (SEM). Sample thicknesses were compared using a one-way ANOVA. XPS reported low phosphorous concentrations (surrogate marker of dicetyl phosphate) between 0.01-0.19% wt at the sample surfaces (top 10nm). There were significant differences between film thicknesses (P<0.001) observed by SEM. The ATR-IR and ToF-SIMS identified four distinct surface and bulk chemical profiles: 1) Cellophane, 2) Polypropylene, 3) Modified Cellophane, and 4) Unique. Following plasma immersion for 6 weeks, samples showed little change in film thickness or chemical composition. This study confirmed that films used to attenuate portosystemic shunts were commonly not pure cellophane, with significant variations in surface and bulk chemistry. Suspected irritant compounds were not readily identifiable in significant proportions. Pronounced variability existed in both the thickness and chemical composition of these films (surface vs. bulk). The present findings lead to a legitimate question about the reproducibility of shunt occlusion when using thin plastic films from different origins.

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Pleurodesis for spontaneous pneumothorax

Ofoegbu¹

1980

The American Journal of Surgery

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Intrapleural Insufflation of Dicetyl Phosphate to Promote Pleural Symphysis

Cited by 7 publications

References 5 publications

Long‐term clinical outcomes of dogs with single congenital extrahepatic portosystemic shunts attenuated with thin film banding or ameroid ring constrictors

Long‐term clinical outcomes of dogs with single congenital extrahepatic portosystemic shunts attenuated with thin film banding or ameroid ring constrictors

The chemical and ultra-structural analysis of thin plastic films used for surgical attenuation of portosystemic shunts in dogs and cats

Pleurodesis for spontaneous pneumothorax

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