Intraperitoneal injections of copper ferrite nanoparticles disturb blood, plasma, and antioxidant parameters of Wistar rats in a sex-specific manner

Riaz, Hasna; Hashmi, R. Y.; Abid, Shairyar; Shareef, Nisha; Faqir, Abida; Amir, Aqsa; Shahzad, Muhammad; Shakeel, Muhammad; Akhtar, Saeed; Ashiq, Muhammad Naeem; Ibrahim, Ather

doi:10.1007/s00210-020-01899-x

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…Male mice were also observed to respond to nanoparticle administration with increased triglyceride levels, which was not observed in females and that may raise concerns for patients at-risk for cardiovascular disease. Sex differences were observed for female versus male rats after treatment with CuNPs, particularly at high doses, and these differences were not observed in the free ion Cu (non-nanoparticle) groups (Riaz et al, 2020). Complex and sex-dependent effects on serum biochemistry for female versus male rats following administration of CuNPs have been reported by other investigators (Kim et al, 2016).…”

Section: Biochemistry and Complete Blood Countsupporting

confidence: 51%

Acute brain injury and nanomedicine: sex as a biological variable

Simmons,

Mihalek,

Bimonte Nelson

et al. 2024

Front. Biomater. Sci.

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Sex as a biological variable has been recognized for decades to be a critical aspect of the drug development process, as differences in drug pharmacology and toxicity in female versus male subjects can drive the success or failure of new therapeutics. These concepts in development of traditional drug systems have only recently begun to be applied for advancing nanomedicine systems that are designed for drug delivery or imaging in the central nervous system (CNS). This review provides a comprehensive overview of the current state of two fields of research - nanomedicine and acute brain injury—centering on sex as a biological variable. We highlight areas of each field that provide foundational understanding of sex as a biological variable in nanomedicine, brain development, immune response, and pathophysiology of traumatic brain injury and stroke. We describe current knowledge on female versus male physiology as well as a growing number of empirical reports that directly address sex as a biological variable in these contexts. In sum, the data make clear two key observations. First, the manner in which sex affects nanomedicine distribution, toxicity, or efficacy is important, complex, and depends on the specific nanoparticle system under considerations; second, although field knowledge is accumulating to enable us to understand sex as a biological variable in the fields of nanomedicine and acute brain injury, there are critical gaps in knowledge that will need to be addressed. We anticipate that understanding sex as a biological variable in the development of nanomedicine systems to treat acute CNS injury will be an important determinant of their success.

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Section: Biochemistry and Complete Blood Countsupporting

confidence: 51%

Acute brain injury and nanomedicine: sex as a biological variable

Simmons,

Mihalek,

Bimonte Nelson

et al. 2024

Front. Biomater. Sci.

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Nanoparticle Properties Modulate Their Effect on the Human Blood Functions

et al. 2021

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Toxicological evaluation of copper oxide nanoparticles following their intraperitoneal injection to Wistar rats

Shareef,

Abid,

Amir

et al. 2024

Toxicology Research

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Background Copper oxide (Cu2O) nanoparticles (CO NPs) are in extensive use during our everyday life as antimicrobial agent, lubricant, in manufacturing electrodes of lithium ion batteries as well as for photo catalytic degradation of organic pollutants. Due to extensive and diverse use Cu2O NPs, they are likely to accumulate in the environment and to affect the live forms. Present investigation was aimed to report the biocompatibility of CO NPs in Wistar rats in sex specific manner. CO NPs, having average diameter of 14.06 nm, were synthesized by co-precipitation method and scanning electron microscopy and X ray diffraction were used for their characterization. Methods For 14 consecutive days, Wistar rats (6 weeks old) of both sexes were intraperitoneally injected with 10 mg/mL saline/Kg body weight of CO NPs, while the control groups intraperitoneally received saline solution for same duration. Behavioral tests (open field and novel object recognition), complete blood count, selected biomarkers of oxidative stress and Copper concentration in brain and liver were determined in all subjects. Results High mortality rates [male 40% and female 60%] were observed in rats exposed to CO NPs. A sever decrease in body weight was also observed in both male and female rats exposed to CO NPs. Female rats treated with CO NPs spent significantly more time with novel object as compared to control [P = 0.05] during second trial of novel object test. CO NPs treated female rats had higher mean corpuscular hemoglobin [P < 0.001] levels and Copper concentration in liver [P = 0.04] than control. Male rats exposed to CO NPs had significantly higher mean corpuscular volume [P = 0.02] and superoxide dismutase [SOD] [P = 0.04] in lungs than their control group. All other studied parameters non significantly varied upon comparison between CO NPs treated and untreated rats of both sex. Conclusion In conclusion, we are reporting that intraperitoneal injections of CO NPs for 14 days can disturb complete blood count and biomarkers of oxidative stress in lungs of Wistar rats.

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Intraperitoneal injections of copper ferrite nanoparticles disturb blood, plasma, and antioxidant parameters of Wistar rats in a sex-specific manner

Cited by 4 publications

References 20 publications

Acute brain injury and nanomedicine: sex as a biological variable

Acute brain injury and nanomedicine: sex as a biological variable

Nanoparticle Properties Modulate Their Effect on the Human Blood Functions

Toxicological evaluation of copper oxide nanoparticles following their intraperitoneal injection to Wistar rats

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