Intraparenchymal Spinal Cord Ganglioneuroblastoma Originating from the Peripheral Sympathetic Nervous System in a Cat

Rivard, B.C.; Hague, Devon W.; Joslyn, Stephen; Zhang, X.; Lezmi, Stéphane

doi:10.1111/jvim.13835

Cited by 3 publications

(10 citation statements)

References 17 publications

(32 reference statements)

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“…In the present case, vertebral canal widening with smooth margins presumably represented pressure atrophy of the vertebrae, which indicated slowly expansile lesion 8 within the vertebral canal [3]. In dogs and cats, neoplastic lesions, such as peripheral nerve sheath tumors and intraparenchymal spinal cord ganglioneuroblastoma [2,23], and non-neoplastic lesions, including spinal arachnoid diverticula [11], have been reported as causes of pressure atrophy of the vertebrae. However, to the best of our knowledge, this finding has not been described in dogs or cats with SEA presumably because the clinical signs of SEA typically progress rapidly [9,10,16,24].…”

mentioning

confidence: 67%

Chronic spinal epidural abscess in a cat: a case report with an unusual imaging finding

Miki

Yamashita

Okamoto

et al. 2022

The Journal of Veterinary Medical Science

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A 1-year-old domestic shorthair cat was evaluated for a chronic history of back pain, dysuria, and paraplegia. Radiographic and computed tomographic examinations showed circumferential widening of the vertebral canal at T13 and T14. A spinal epidural abscess (SEA) compressing the spinal cord from the level of T11 to L1 was suspected following intravenous contrast administration, and was confirmed by surgical exploration and histopathological analysis. The cat recovered its motor and bladder functions following surgical decompression and antibiotic therapy. SEA is a neurological emergency requiring prompt treatment. However, the present case had a prolonged disease course and pressure atrophy of the vertebrae was strongly suspected. To our knowledge, this imaging finding has not been reported in dogs or cats with SEA.

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mentioning

confidence: 67%

Chronic spinal epidural abscess in a cat: a case report with an unusual imaging finding

Miki

Yamashita

Okamoto

et al. 2022

The Journal of Veterinary Medical Science

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“…Olfactory and oral mucosa ganglioneuroblastomas have been described in dogs (MATTIX et al, 1994;NAKAMURA et al, 2004). In cats, they have been reported in the plantar region of the pelvic limb and spinal cord, extending from the fifth to the seventh lumbar vertebrae (SPUGNINI et al, 2008;RIVARD et al, 2016).…”

Section: Neuronalmentioning

confidence: 99%

“…The diagnosis of neuropathologies has benefited greatly from IHC; however, there is a high degree of variability in immunoreactive patterns (KOESTNER & HIGGINS, 2002;RIVARD et al, 2016). In animals, the ganglion cells of ganglioneuroma and ganglioneuroblastoma are strongly immunoreactive for neurofilament (KOESTNER & HIGGINS, 2002).…”

Section: Neuronalmentioning

confidence: 99%

“…This current report had very similar immunoreactivity to that described by NAKAMURA et al (2004), with the addition of GFAP immunoreactivity in ganglion cells. Although these types of tumors are extremely rare, diagnostic criteria and differential diagnosis are necessary, as is specifying the type of ganglion cell neoplasm (JOSHI, 2000;RIVARD et al, 2016). If the mass contains mainly neuroblasts (immature ganglion cells), it is referred to as neuroblastoma; however, when the mass is composed entirely of mature ganglion cells and other mature tissue, it is considered a ganglioneuroma, while ganglioneuroblastomas have both immature and mature cells (JOSHI, 2000).…”

Section: Neuronalmentioning

confidence: 99%

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Facial nerve ganglioneuroblastoma in a feline leukemia virus-positive cat

et al. 2017

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Neuroblastic tumors can originate from the central neuraxis, olfactory epithelium, adrenal medullary region or autonomous system. Ganglioneuroblastoma are a type of neuroblastic tumor, with very few case descriptions in animals. Diagnosis of facial nerve ganglioneuroblastoma was made in a feline leukemia virus-positive 11-month-old cat. The cat had hyporexia, left head tilt, depressed mental state, horizontal nystagmus, inability to retract the pinched left lip, anisocoria, ptosis, and absence of the menace reflex. Gross necropsy showed a mass at the left facial nerve root region. Histological examination of this mass showed neoplastic proliferation of neuroblasts arranged in a cohesive pattern and mature ganglion cells. Ganglion cells were positive for neurofilament, neuron-specific enolase, S100, and glial fibrillary acidic protein by immunohistochemistry, while neuroblasts were positive for vimentin, S100, neuron-specific enolase and feline leukemia virus.

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“…[4][5][6] Bone lysis is not frequently reported as a result of NST, with few veterinary reports briefly describing osteolysis in different body locations. [3][4][5][6][7][8][9][10][11] Osseous destruction caused by NST is also very rarely seen in people, with very few cases affecting the skull. 12 This is the first report and imaging description of maxillary osteolysis secondary to NST in a young dog.…”

Section: Introductionmentioning

confidence: 99%

Maxillary osteolysis as a result of trigeminal nerve sheath tumour in a dog

Indzhova

Batlle

Gomes³

et al. 2022

Vet Record Case Reports

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A 2.5‐year‐old, female, entire Labrador retriever presented with right‐sided head tilt, vestibular ataxia and right‐sided masticatory muscle atrophy. The most likely neuroanatomical localisation was the right‐sided brainstem involving the vestibular system and also the trigeminal nerve. Magnetic resonance imaging and computed tomography revealed enlargement of the right trigeminal nerve and osteolysis of the corresponding innervated maxillary bone. Histopathological analysis confirmed a malignant nerve sheath tumour of the trigeminal nerve that adhered, infiltrated, invaded and fragmented the bone. This is the first report and imaging description of maxillary osteolysis secondary to nerve sheath tumour in a dog.

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Intraparenchymal Spinal Cord Ganglioneuroblastoma Originating from the Peripheral Sympathetic Nervous System in a Cat

Cited by 3 publications

References 17 publications

Chronic spinal epidural abscess in a cat: a case report with an unusual imaging finding

Chronic spinal epidural abscess in a cat: a case report with an unusual imaging finding

Facial nerve ganglioneuroblastoma in a feline leukemia virus-positive cat

Maxillary osteolysis as a result of trigeminal nerve sheath tumour in a dog

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