Intrapapillary Proliferation in Optic Disk Pits

Abstract

All examined eyes with ODP showed signs of intrapapillary and prepapillary tissue, which developed over time. SD-EDI-OCT and MHz-OCT are able to detect characteristic ODP-related findings and are a useful means to monitor time-related changes within intrapapillary and prepapillary tissue related to ODP and ODP-M.

Role of the Epipapillary Membrane in Maculopathy Associated with Cavitary Optic Disc Anomalies: Morphology, Surgical Outcomes, and Histopathology

“…In all our patients without preoperative PVD, preoperative OCT revealed that the epipapillary membrane was present at the excavation sites of the disc, as shown in a recent study [ 17 ]. The hyaloid membrane was attached to not only the optic disc but also the epipapilary membrane in most of these patients.…”

“…Furthermore, a tunnel-like hyporeflectivity connecting the schisis and the excavation site of the disc observed with SD-OCT preoperatively became obscured from the early stage after surgery [ 21 ]. Intrapapillary proliferation was observed in all of 16 ODP maculopathy eyes [ 17 ]. The proliferation that sequentially developed was likely to cause the development of cavity within the pit [ 17 ].…”

“…Intrapapillary proliferation was observed in all of 16 ODP maculopathy eyes [ 17 ]. The proliferation that sequentially developed was likely to cause the development of cavity within the pit [ 17 ]. Therefore, our current results suggest that the growth of the residual epipapillary membrane continues drawing the vulnerable disc tissues, even after PVD spontaneously occurred, and is involved in the pathogenesis of this maculopathy with preoperative PVD.…”

“…A recent study using spectral domain optical coherence tomography (SD-OCT) demonstrated that all eyes with ODP involved epipapillary membrane, which developed over time [ 17 ]. Although the membrane may be related to the pathogenesis of ODP maculopathy by dragging the disc, surgical outcomes of PPV with epipapillary membrane removal have previously been reported in only one case [ 18 ].…”

A Case of Multiple Optic Disc Pits: 21-Year Follow-up

“… 9 Other important OCT findings are intrapapillary cavities, intrapapillary proliferations, septum-like structures, and subretinal precipitates which can be detected as a marker for chronicity of maculopathy. 18 , 19 In our patient, one eye had fluid accumulation under the optic nerve head and an intrapapillary septum structure ( Figure 2C ).…”