Intraovarian actions of oestrogen

Rosenfeld, C.

doi:10.1530/reprod/122.2.215

Cited by 29 publications

(35 citation statements)

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“…Estrogen and progesterone, for example, have strong effects on proliferation/differentiation and apoptosis in the uterus, mammary glands, ovaries, bone, and central nervous system that may also be influenced by cytokines, such as TNF␣ and FasL (41)(42)(43)(44). Thus, FLASH might play an important role in the actions of these hormones or other nuclear hormones as well.…”

Section: Discussionmentioning

confidence: 99%

Tumor Necrosis Factor α Receptor- and Fas-associated FLASH Inhibit Transcriptional Activity of the Glucocorticoid Receptor by Binding to and Interfering with Its Interaction with p160 Type Nuclear Receptor Coactivators

Kino

Chrousos

2003

Journal of Biological Chemistry

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Tumor necrosis factor ␣ (TNF␣) and its downstream transcription factor nuclear factor B (NF-B) suppress glucocorticoid action, contributing to tissue resistance to glucocorticoids in several pathologic inflammatory states. p160 nuclear receptor coactivators on the other hand, contribute to the transcriptional signal of the glucocorticoid receptor (GR) through interaction with it via LXXLL motifs in their nuclear receptor-binding (NRB) domain. To discover TNF␣-induced factors that regulate GR activity at the coactivator level, we performed yeast two-hybrid screening using the NRB domain of the glucocorticoid receptor-interacting protein 1 (GRIP1) as bait. We found that FLICE-associated huge protein (FLASH), which transduces TNF␣ and Fas ligand signals, bound the NRB domain of GRIP1 at a region between the second and third LXXLL motifs. FLASH suppressed both GR transactivation and GRIP1 enhancement of the glucocorticoid signal and inhibited the physical interaction between GR and the GRIP1 NRB domain. Transfected green fluorescent proteinfused FLASH was located in both the cytoplasm and nucleus, while endogenous FLASH shifted its subcellular localization from the cytoplasm into the nucleus in response to TNF␣. FLASH antisense and super-repressor IB␣ inhibited the action of TNF␣ independently of each other and additively. These findings indicate that FLASH participates in TNF␣-induced blockade of GR transactivation at the nuclear receptor coactivator level, upstream and independently of NF-B.

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Section: Discussionmentioning

confidence: 99%

Tumor Necrosis Factor α Receptor- and Fas-associated FLASH Inhibit Transcriptional Activity of the Glucocorticoid Receptor by Binding to and Interfering with Its Interaction with p160 Type Nuclear Receptor Coactivators

Kino

Chrousos

2003

Journal of Biological Chemistry

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“…The main hormones involved in these processes are androgens, estrogens, and progesterone (Rosenfeld et al 2001, Drummond et al 2002, Schams & Berisha 2002, Brosens 2004, Drummond 2006, Kimura et al 2007). Steroid hormones act through specific receptors that are members of a superfamily of ligand-dependent transcriptional activators, which directly regulate the expression of specific gene complexes involved in regulating the differentiation and growth of reproductive tissues, as well as other metabolic processes (Brosens 2004).…”

Section: R253mentioning

confidence: 99%

Molecular aspects of bovine cystic ovarian disease pathogenesis

Ortega¹,

Marelli²,

Rey³

et al. 2015

Reproduction

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Cystic ovarian disease (COD) is one of the main causes of reproductive failure in cattle and causes severe economic loss to the dairy farm industry because it increases both days open in the post partum period and replacement rates due to infertility. This disease is the consequence of the failure of a mature follicle to ovulate at the time of ovulation in the estrous cycle. This review examines the evidence for the role of altered steroid and gonadotropin signaling systems and the proliferation/apoptosis balance in the ovary with cystic structures. This evidence suggests that changes in the expression of ovarian molecular components associated with these cellular mechanisms could play a fundamental role in the pathogenesis of COD. The evidence also shows that gonadotropin receptor expression in bovine cystic follicles is altered, which suggests that changes in the signaling system of gonadotropins could play a fundamental role in the pathogenesis of conditions characterized by altered ovulation, such as COD. Ovaries from animals with COD exhibit a disrupted steroid receptor pattern with modifications in the expression of coregulatory proteins. These changes in the pathways of endocrine action would trigger the changes in proliferation and apoptosis underlying the aberrant persistence of follicular cysts. Free Spanish abstract: A Spanish translation of this abstract is freely available at

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“…Oestradiol has not been shown to have direct effects on follicle growth in horses. However, in other species, it promotes development of preantral follicles and stimulates steroidogenesis in granulosa and theca cells in vitro (cattle), stimulates follicle growth and development in vivo and in vitro and inhibits granulosa cell apoptosis (mice and rats), and increases the sensitivity of granulosa cells to FSH and LH by promoting the expression of their receptors and regulating formation of gap junctions among granulosa cells in vivo (rats; for a review, see Rosenfeld et al (2001a)). In pigs and sheep, oestradiol promotes the synthesis of IGF-I (Spicer & Chamberlain 2000).…”

Section: Steroidsmentioning

confidence: 99%

Follicle selection in cattle and horses: role of intrafollicular factors

Beg¹,

Ginther²

2006

Reproduction

143

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The eminent event in follicle selection during a follicular wave in monovular species is diameter deviation, wherein one follicle continues to grow (developing dominant) and other follicles (subordinates) begin to regress. In cattle, the IGF system, oestradiol and LH receptors are involved in the intrafollicular events initiating deviation as indicated by the following: (1) concentrations of free IGF-I and oestradiol in the follicular fluid and number of LH receptors in the follicular wall increase more dramatically in the future dominant follicle than in the future subordinate follicles before the beginning of deviation and (2) ablation of the largest follicle (LF) or injection of recombinant human IGF (rhIGF)-I into the second LF at the expected beginning of deviation increases the concentrations of oestradiol in second LF before the expected beginning of deviation between second LF and third LF. In horses, an increase in free IGF-I, oestradiol, inhibin-A and activin-A is greater in the future dominant follicle than in other follicles before the beginning of deviation. However, free IGF-I is the only one of these four factors needed for the initiation of deviation in horses as indicated by the following: (1) ablation of LF at the expected beginning of deviation increases the concentrations of free IGF-I in second LF before the beginning of deviation between second LF and third LF but does not increase the other factors; (2) injection of rhIGF-I into second LF at the expected beginning of deviation causes second LF to continue to grow and become a codominant follicle and (3) injection of IGF-binding protein-3 into LF at the expected beginning of deviation causes LF to regress and second LF to become dominant. Thus, the dramatic changes in the IGF system in LF compared to other follicles before the beginning of deviation play a crucial role in the events that lead to the beginning of diameter deviation in both cattle and horses. Oestradiol and LH receptors also play a role in cattle. These intrafollicular events prepare the selected follicle for the decreasing availability of FSH and increasing availability of LH. The other follicles of the wave have the same future capability but do not have adequate time to attain a similar preparatory stage.

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Intraovarian actions of oestrogen

Cited by 29 publications

References 0 publications

Tumor Necrosis Factor α Receptor- and Fas-associated FLASH Inhibit Transcriptional Activity of the Glucocorticoid Receptor by Binding to and Interfering with Its Interaction with p160 Type Nuclear Receptor Coactivators

Tumor Necrosis Factor α Receptor- and Fas-associated FLASH Inhibit Transcriptional Activity of the Glucocorticoid Receptor by Binding to and Interfering with Its Interaction with p160 Type Nuclear Receptor Coactivators

Molecular aspects of bovine cystic ovarian disease pathogenesis

Follicle selection in cattle and horses: role of intrafollicular factors

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