Intraoral granulocytic sarcoma as a manifestation of myelofibrosis: A case report and review of the literature

Abstract

Granulocytic sarcoma (GS) is an extramedullary tumor associated with myelodysplastic syndromes or myeloproliferative diseases. Intraoral manifestations are considered uncommon, with a reasonable number of cases, and are mostly related to leukemia. The association of oral GS and myelofibrosis is very rare and only three cases have been published. In this paper, we report the fourth case of oral lesion in a patient with a diagnosis of myelofibrosis. The aim of this study was to present a review of the literature, discussing the current and previous cases of oral GS associated with myelofibrosis or other hematological disorders and the importance of accurate diagnosis through clinical, microscopic, and immunohistochemical features.

<p>Urgent Chemotherapy Successfully Rescues a Near Death Patient of Acute Intracranial Hypertension Caused by Intracranial Myeloid Sarcoma</p>

“…Myeloid sarcoma can be caused by AML, 3 chronic myeloid leukemia (CML), 4,5 chronic myelomonocytic leukemia (CMML), 6 and primary myelofibrosis (PMF). [7][8][9] It has been reported that intracranial myeloid sarcoma may originate from the superficial arachnoid vein wall and extend into the cerebrospinal fluid. The expanded leukemic mass infiltrates into the brain parenchyma through the cortical glial membrane and eventually forms intracerebral tumor.…”