Intraoperative Use of a Portable Large Field of View Gamma Camera and Handheld Gamma Detection Probe for Radioguided Localization and Prediction of Complete Surgical Resection of Gastrinoma: Proof of Concept

Hall, Nathan C.; Nichols, Shawnn D.; Povoski, Stephen P.; James, Iyore; Wright, Chadwick; Harris, Randall E.; Schmidt, Carl; Muscarella, Peter; Latchana, Nicholas; Martin, Edward W.; Ellison, E. Christopher

doi:10.1016/j.jamcollsurg.2015.03.047

Cited by 17 publications

(20 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most commonly used tumor-targeting peptide imaging agent is Indium-111 ( 111 In)-labeled pentetreotide which binds to these somatostatin-receptor expressing tumors. 111 In-labeled pentetreotide can be imaged intraoperatively using portable gamma camera imaging, 33 or it can be imaged conventionally with planar scintigraphy, SPECT and SPECT/CT imaging. 34 This approach requires injection-to-scan times ranging from 4 to 48 h.…”

Section: Potential For Advanced Molecular Imaging and Theranostics Wimentioning

confidence: 99%

“…Radioguided surgical approaches have been demonstrated and are clinically effective. 33 , 53 , 54 , 55 Ex vivo gamma/PET and fluorescent imaging of resected specimens for more rapid and precise radiologic–pathologic correlation and assessment. Following surgical resection, any residual microscopic malignancy or metastatic lesions could be further treated using a therapeutic radioisotope (e.g., 90Y, 131I, 177Lu) conjugated to the HN-1 peptide agent.…”

Section: Theranostics and Precision Otolaryngologymentioning

confidence: 99%

“…Radioguided surgical approaches have been demonstrated and are clinically effective. 33 , 53 , 54 , 55 …”

Section: Theranostics and Precision Otolaryngologymentioning

confidence: 99%

See 2 more Smart Citations

Advancing theranostics with tumor‐targeting peptides for precision otolaryngology

Wright

Pan

Knopp

et al. 2016

World j. otorhinolaryngol.-head neck surg.

Self Cite

View full text Add to dashboard Cite

Worldwide, about 600,000 head and neck squamous cell carcinoma (HNSCC) are detected annually, many of which involve high risk human papilloma virus (HPV). Surgery is the primary and desired first treatment option. Following surgery, the existence of cancer cells at the surgical margin is strongly associated with eventual recurrence of cancer and a poor outcome. Despite improved surgical methods (robotics, microsurgery, endoscopic/laparoscopic, and external imaging), surgeons rely only on their vision and touch to locate tumors during surgery. Diagnostic imaging systems like computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and positron-emission tomography (PET) are too large, slow and costly to use efficiently during most surgeries and, ultrasound imaging, while fast and portable, is not cancer specific. This purpose of this article is to review the fundamental technologies that will radically advance Precision Otolaryngology practices to the benefit of patients with HNSCC. In particular, this article will address the potential for tumor-targeting peptides to enable more precise diagnostic imaging while simultaneously advancing new therapeutic paradigms for next generation image-guided surgery, tumor-specific chemotherapeutic delivery and tumor-selective targeted radiotherapy (i.e., theranostic).

show abstract

Section: Potential For Advanced Molecular Imaging and Theranostics Wimentioning

confidence: 99%

Section: Theranostics and Precision Otolaryngologymentioning

confidence: 99%

See 1 more Smart Citation

Advancing theranostics with tumor‐targeting peptides for precision otolaryngology

Wright

Pan

Knopp

et al. 2016

World j. otorhinolaryngol.-head neck surg.

Self Cite

View full text Add to dashboard Cite

show abstract

“…As preoperative high-resolution (3D) imaging has been demonstrated to offer advantages for LN mapping, scintigraphic imaging has also been transferred to the operating room to facilitate and improve the localization of SLNs. In specialized centers, mobile large field of view (FOV) and portable or handheld small FOV gamma cameras are utilized concurrently with gamma probes for intraoperative scintigraphic imaging [15,34]. These devices cover a larger FOV than gamma probes [35].…”

Section: Toward Intraoperative 3d Imagingmentioning

confidence: 99%

“…Recently, a simulation model demonstrated that SLNs can be detected at a distance of 3 mm from the injection site owing to the high resolution of the pinhole collimated system [39]. Mobile large FOV gamma cameras may be used if a complex anatomic region is to be covered within one image acquisition [34]. However, final in vivo localization of the radioactive labeled tissue has to be guided by a handheld gamma probe.…”

Section: Toward Intraoperative 3d Imagingmentioning

confidence: 99%

New technologies in radioguided surgery in complex anatomic areas

Bluemel

Herrmann

2016

Clin Transl Imaging

View full text Add to dashboard Cite

Sentinel lymph node biopsy (SLNB) is the most common radioguided surgery procedure and standard of care for lymph node staging in clinically node-negative patients with melanoma and breast cancer. While SLNB has also emerged as a potential alternative to lymph node dissection for staging in patients with other solid malignancies, its use for this purpose has to date not been widely accepted owing to technical limitations in complex anatomic areas such as the head and neck and the pelvic region. However, new technologies have recently been developed to overcome these limitations. This review focuses on the new technologies that improve SLN localization in complex anatomic areas, including new diagnostic tracers ( 99m Tc-tilmanocept and hybrid tracers), preoperative SPECT/CT imaging, and scintigraphic threedimensional intraoperative imaging techniques.

show abstract