Intraoperative sentinel lymph node examination by imprint cytology and frozen sectioning during breast surgery

Motomura, Kazuyoshi; Inaji, Hideo; Komoike, Yoshifumi; Kasugai, Tsutomu; Nagumo, Sachiko; Noguchi, Shinzaburo; Koyama, Hiroki

doi:10.1046/j.1365-2168.2000.01423.x

Cited by 186 publications

(138 citation statements)

References 24 publications

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“…4,9,10 Some of these techniques increase the laboratory workload at the time of frozen section quite dramatically, but sensitivities (in reports with more than 100 patients) have been as high as 93%. 4 Recently, Krogerus compared two frozen section Frozen section of sentinel nodes ML Mitchell techniques.…”

Section: Discussionmentioning

confidence: 99%

Frozen section diagnosis for axillary sentinel lymph nodes: the first six years

Mitchell

2005

Modern Pathology

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Intraoperative frozen section of axillary lymph nodes for the detection of metastatic breast cancer has been controversial because of the labor-intensive techniques necessary to obtain a highly sensitive test, and because of the uncertain significance of frequently detected submicrometastatic carcinoma. In total, 874 consecutive axillary sentinel lymph node cases examined by intraoperative frozen section over a 6-year period were reviewed retrospectively. Frozen section had a sensitivity of 60% and was 100% specific, but when cases with submicrometastatic tumor cells were considered negative, the sensitivity rose to 83%. Rare cases were called 'atypical' on frozen section; almost all of these cases were negative for carcinoma on permanent sections.

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Section: Discussionmentioning

confidence: 99%

Frozen section diagnosis for axillary sentinel lymph nodes: the first six years

Mitchell

2005

Modern Pathology

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“…In addition, Lee et al, 6 HenryTillman et al, 8 Llatjos et al, 4 and Van Diest et al 1 all used H & E alone as a gold standard, whereas most other studies used H & E in conjunction with CK immunohistochemistry. 2,10,11,13,16,21,29 Two apparent outliers in terms of reported accuracy are the studies of Motomura et al 2 and Henry-Tillman et al 8 Motomura and colleagues, who excluded clinically positive lymph nodes and analyzed lymph nodes from patients with T1-2 tumors using H & E alone or H & E with CK immunostaining as a reference, reported a remarkable sensitivity rate of 92% on the lymph node level.…”

Section: Discussionmentioning

confidence: 99%

“…8 These outliers may be partially attributable to sectioning protocols. Lymph nodes were sectioned at 2 mm thickness and 2-3 mm thickness during imprint cytology by Motomura et al 2 and Henry-Tillman et al, 8 respectively. In contrast, numerous other studies, including the current one, typically bisected lymph nodes or cut sections measuring Ͼ 2 mm in thickness.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma

Cox

Centeno

Dickson

et al. 2004

Cancer

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“…It is quick and easy to perform and gives similar results to frozen sections. [40][41][42] Both techniques, however, rely on the availability of a highly skilled pathologist, and it is likely that the excellent results reported from specialist units will not be replicated in smaller hospitals relying on a general pathologist for reporting. A real-time optical method for determining sentinel node involvement would provide significant benefits to patients undergoing surgery for breast cancer.…”

Section: Elastic Scattering Spectroscopymentioning

confidence: 99%

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Bigio

Bown²

2004

Cancer Biology & Therapy

143

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Various types of optical spectroscopy have been investigated as methods to effect a non-invasive, real-time in-situ assessment of tissue pathology. All of these methods have one basic principle in common: the optical spectrum of a tissue contains information about the biochemical composition and/or the structure of the tissue, and that information conveys diagnostic information. The biochemical information can be obtained by measuring absorption, fluorescence, or Raman scattering signals. Structural and morphological information may be obtained by techniques that assess the elastic-scattering properties of tissue. These basic approaches are useful for the detection of cancer as well as for other diagnostic applications such as hemoglobin saturation, intra-luminal detection of atherosclerosis, and simply the identification of different tissue types during procedures. Optical spectroscopic measurements can also be employed in the management of disease treatment. The site-specific pharmacokinetics of chemotherapy and photodynamic therapy agents can be used to customize dosage to the patient, and diagnostic spectroscopy can be used to monitor response to treatment. In recent years clinical studies have provided indications of potential efficacy, and some of these modalities are now entering a translational research stage, with an eye to approval and commercialization. A benefit of these methods is their inherent low cost and ease of implementation, generally mediated with small portable instruments, not requiring any specialized facilities, and eventually not requiring expert interpretation. This paper reviews briefly the most common methods of diagnostic optical spectroscopy, and reviews in greater depth recent clinical translational research invoking scattering spectroscopy as the enabling technology, which has been the experience of the authors.

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Intraoperative sentinel lymph node examination by imprint cytology and frozen sectioning during breast surgery

Abstract: Intraoperative imprint cytology is a useful method for evaluating the status of sentinel nodes and is more accurate than frozen-section analysis. In addition, imprint cytology can detect micrometastasis more accurately than conventional haematoxylin and eosin-stained sectioning.

Cited by 186 publications

References 24 publications

Frozen section diagnosis for axillary sentinel lymph nodes: the first six years

Frozen section diagnosis for axillary sentinel lymph nodes: the first six years

Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

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