Intraoperative Narrow Band Imaging Better Delineates Superficial Resection Margins During Transoral Laser Microsurgery for Early Glottic Cancer

Garofolo, Sabrina; Piazza, Cesare; Bon, Francesca Del; Mangili, Stefano; Guastini, Luca; Mora, Francesco; Nicolai, Piero; Peretti, Giorgio

doi:10.1177/0003489414556082

Cited by 78 publications

(93 citation statements)

References 25 publications

(39 reference statements)

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“…Only one published study has addressed the intraoperative application of NBI to better delineate the superficial resection margins in early glottis cancer; the authors report an increase in the accuracy of the evaluation of superficial spread of the neoplasm, with a consequent reduction in the rate of positive margins [49].…”

Section: Discussionmentioning

confidence: 99%

Narrow band imaging in the intra-operative definition of resection margins in oral cavity and oropharyngeal cancer

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Narrow band imaging in the intra-operative definition of resection margins in oral cavity and oropharyngeal cancer

et al. 2015

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“…Kraft found accuracy to increase from 90 to 97% when using NBI as opposed to routine white light endoscopy [80]. Finally, Garofolo found that when using NBI to guide resection margins, the rate of positive superficial margins was 3.6% as opposed to 23.7% in a control group [81]. The diagnostic advantage afforded by NBI has also been shown to apply after radiation and/or chemotherapy [82, 83].…”

Section: Recent Advances In Tlm-related Areasmentioning

confidence: 99%

Transoral Laser Microsurgery in Early Glottic Lesions

Sjögren

2017

Curr Otorhinolaryngol Rep

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Purpose of ReviewTo give an overview of the evolvement of transoral laser microsurgery (TLM) in the treatment of early glottic carcinoma and highlight the contribution of recent literature.Recent FindingsThe indications and limits of TLM have been well specified. Effects on swallowing have been well documented. Introduction of narrow-band imaging (NBI) and diffusion-weighted magnetic resonance has been shown of additional value for outcome. The first reports on transoral robotic surgery show that it may be of added value in the future.SummaryTLM for early glottic carcinoma (Tis–T2) has very good oncological outcomes with indications of higher larynx preservation in TLM than that in radiotherapy. The anterior commissure is a risk factor if involved in the cranio-caudal plane, and reduced vocal fold mobility is a risk factor when this is due to arytenoid involvement. The best voice results are achieved when the anterior commissure can be left intact along with part of the vocal fold muscle although even in larger resections, patient self-reported voice handicap is still limited.

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“…Autofluorescence detects the loss of autofluorescence of tissues due to alterations of fluorophore distribution, such as collagen breakdown and flavin adenine dinucleotide concentration decrease, associated with malignant transformation. Both these approaches have already achieved successful clinical experimentation and are currently used by several head and neck surgeons to obtain early diagnosis and to perform a more targeted surgery, in particular concerning the wideness of superficial resection [114,115,[127][128][129][130][131]. An additional imaging technology, potentially useful for a better assessment of tumor thickness, depth of invasion and resection margins of OSCC, is intraoral ultrasound (US) [40,41,132].…”

Section: Optical Techniquesmentioning

confidence: 99%

Open questions and novel concepts in oral cancer surgery

Tirelli

Zacchigna

Biasotto

et al. 2015

Eur Arch Otorhinolaryngol

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The persistence of cancerous cells after surgery in oral squamous cell carcinoma (OSCC) represents a major challenge, as it often leads to local recurrences and secondary primary tumors, which are eventually responsible for a large proportion of deaths. This persistence is currently evaluated by histological analyses. In this review we discuss some important pitfalls of the histopathological analysis, such as margin evaluation, specimen shrinkage and T staging. In addition, we critically analyze the appropriateness of current surgical techniques in relation to the concept of field cancerization. Finally, we describe some novel imaging and molecular approaches, which might be useful in tailoring surgical resections and encourage the use of OSCC animal models to explore and provide proof of concept of the feasibility and potential clinical utility of innovative surgical protocols.

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Intraoperative Narrow Band Imaging Better Delineates Superficial Resection Margins During Transoral Laser Microsurgery for Early Glottic Cancer

Abstract: Routine use of intraoperative NBI increases the accuracy of neoplastic superficial spreading evaluation during TLM for early glottic cancer.

Cited by 78 publications

References 25 publications

Narrow band imaging in the intra-operative definition of resection margins in oral cavity and oropharyngeal cancer

Narrow band imaging in the intra-operative definition of resection margins in oral cavity and oropharyngeal cancer

Transoral Laser Microsurgery in Early Glottic Lesions

Open questions and novel concepts in oral cancer surgery

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