Intraoperative Microwave Ablation of Pulmonary Malignancies with Tumor Permittivity Feedback Control: Ablation and Resection Study in 10 Consecutive Patients

Wolf, Farrah J.; Aswad, Bassam I.; Ng, Tony; Dupuy, Damian E.

doi:10.1148/radiol.11110015

Cited by 30 publications

(31 citation statements)

References 17 publications

(22 reference statements)

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“…In recent research that evaluating MWA with tumour permittivity feedback in lung tissue, Wolf et al 9 reported the application of ablation therapy as close as 4 mm from blood vessels with no evidence of heat sink or collateral vascular damage. This suggests the possibility of improved outcomes, compared with conventional forms of thermal ablation.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 The newly designed Medwaves MWA system provides a tissue permittivity feedback control mechanism that allows real-time monitoring of ablation conditions as well as modulation of the power and frequency of microwave energy. 9 Maximizing the amount of delivered forward power increases active heating, such that cellular death in the target area is induced more uniformly, using only a single uncooled antenna. 9 The objective of the present study was to evaluate the safety and efficacy of the novel microwave system with an uncooled antenna in the treatment of patients with HCCs exceeding 5 cm.…”

Section: Introductionmentioning

confidence: 99%

“…9 Maximizing the amount of delivered forward power increases active heating, such that cellular death in the target area is induced more uniformly, using only a single uncooled antenna. 9 The objective of the present study was to evaluate the safety and efficacy of the novel microwave system with an uncooled antenna in the treatment of patients with HCCs exceeding 5 cm.…”

Section: Introductionmentioning

confidence: 99%

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Initial institutional experience of uncooled single-antenna microwave ablation for large hepatocellular carcinoma

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Initial institutional experience of uncooled single-antenna microwave ablation for large hepatocellular carcinoma

et al. 2015

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“…Clinical experience following microwave ablation is very limited; only a few case series have been published to date (29)(30)(31)(32). As for RFA, no randomized trials are yet available.…”

Section: Resultsmentioning

confidence: 99%

Thermal Ablation of Malignant Lung Tumors

Schneider

Herth²,

Dienemann³

2013

Deutsches Ärzteblatt International

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SUMMARYBackground: About 50 000 new cases of non-small-cell carcinoma of the lung are diagnosed in Germany each year. More than 20% of the affected patients cannot be offered radical resection because of comorbidity alone. The lung is also the second most common site of distant metastases of extrathoracic tumors; it is the only site of such metastases in 20% of cases. In recent years, image-guided thermoablation has been used with increasing frequency in patients who are unable to undergo surgery for medical reasons.

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“…Since the advent of MWA, several studies have introduced, tested, and compared this system (16)(17)(18)(19)(20)(21)(22), and the legitimate question arose as to whether, with MWA, saline preinjection would also lead to an enlargement of the ablation volume.…”

Section: Resultsmentioning

confidence: 99%

Fluid preinjection for microwave ablation in an ex vivo bovine liver model assessed with volumetry in an open MRI system

Collettini

Schnackenburg²,

Thomas³

et al. 2013

Diagn Interv Radiol

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ORIGINAL ARTICLE PURPOSE We aimed to detect possible differences in microwave ablation (MWA) volumes after different fluid preinjections using magnetic resonance imaging (MRI). MATERIALS AND METHODSMWA volumes were created in 50 cuboid ex vivo bovine liver specimens (five series: control [no injection], 10 mL water, 10 mL 0.9% NaCl, 10 mL 6% NaCl, and 10 mL 12% NaCl preinjections; n=10 for each series). The operating frequency (915 megahertz), ablation time (7 min), and energy supply (45 watts) were constant. Following MWA, two MR sequences were acquired, and MR volumetry was performed for each sequence. RESULTSFor both sequences, fluid preinjection did not lead to significant differences in MWA ablation volumes compared to the respective control group (sequence 1: mean MWA volumes ranged from 7.0±1.2 mm [water] to 7.8±1.3 mm [12% NaCl] vs. 7.3±2.1 mm in the control group; sequence 2: mean MWA volumes ranged from 4.9±1.4 mm [12% NaCl] to 5.5±1.9 mm [0.9% NaCl] vs. 4.7±1.6 mm in the control group). The ablation volumes visualized with the two sequences differed significantly in general (P < 0.001) and between the respective groups (control, P ≤ 0.001; water, P < 0.001; 0.9% NaCl, P < 0.001; 6% NaCl, P ≤ 0.001; 12% NaCl, P < 0.001). The volumes determined with sequence 1 were closer to the expected ablation volume of 8 mL compared to those determined with sequence 2. CONCLUSION For the fluid qualities and concentrations assessed, there is no evidence that fluid preinjection results in larger coagulation volumes after MWA. Because ablation volumes determined by MRI vary with the sequence used, interventionalists should gain experience in how to interpret postinterventional imaging findings (with the MR scanner, sequences, and parameters used) to accurately estimate the outcome of the interventions they perform.T hermal ablation techniques are increasingly used in the treatment of various primary and metastatic tumors at different sites, including the liver (1), kidneys (2), and lungs (3). Local ablation is most commonly performed using thermal ablation techniques such as radiofrequency ablation (RFA). Other techniques include laser-induced thermotherapy, cryoablation, high-intensity focused ultrasonography, and microwave ablation (MWA). Local ablation treatment is particularly appealing in combination with image guidance such as ultrasonography, computed tomography, and magnetic resonance imaging (MRI) to allow a minimally invasive approach to therapy (4-8).Several studies have demonstrated that combining RFA with preinjection of a fluid such as saline (different authors tested a range of concentrations) (9-14) or with diluted hydrochloric acid (15) can yield larger ablation volumes than RFA alone. In addition, both lowfield and high-field MRI can be used to monitor the effectiveness of RFA within NaCl-pretreated tissues, and the findings correlate well with pathologic results (9).Since the advent of MWA, several studies have introduced, tested, and compared this system (16)(17)(18)(19)(20)(21)(22), and the legitim...

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Intraoperative Microwave Ablation of Pulmonary Malignancies with Tumor Permittivity Feedback Control: Ablation and Resection Study in 10 Consecutive Patients

Abstract: MWA with tumor permittivity feedback control results in cytotoxic intratumoral temperatures and extension of ablation zones into aerated peritumoral pulmonary parenchyma, possibly forming the equivalent of an oncologic resection margin.

Cited by 30 publications

References 17 publications

Initial institutional experience of uncooled single-antenna microwave ablation for large hepatocellular carcinoma

Initial institutional experience of uncooled single-antenna microwave ablation for large hepatocellular carcinoma

Thermal Ablation of Malignant Lung Tumors

Fluid preinjection for microwave ablation in an ex vivo bovine liver model assessed with volumetry in an open MRI system

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